Phosphatase Family NagD

Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD

The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:

• PGP is ubiquitous in eukaryotes. The two members in human have distinct functions: PGP is a putative tyrosine-specific protein phosphatase, and PDXP (chronophin) dephosphorylates cofilin on serine, and also dephosphorylates pyridoxal 5'-phosphate. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.

• LHPP is a protein histidine phosphatase subfamily conserved in holozoa.

• CUT - no strong evidence supports it has protein phosphatase activity.