Phosphatase Subfamily ACP6
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: Subfamily ACP6
Evolution
The ACP6 subfamily is found in holozoa except ecdysozoa. Although ecdysozoa lost ACP6, both Drosophila melanogaster and C. elegans have remarkable expansions in another subfamily in HP1 family ACP2.
Domain
Function
Human ACP6 is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate [1]. Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through G-protein-coupled receptors pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including the one through ACP6 [1].
References
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