Phosphatase Family OCA

From PhosphataseWiki
Revision as of 23:55, 26 February 2015 by Mark (Talk | contribs)

Jump to: navigation, search

Phosphatase Classification: Fold CC1: Superfamily CC1: OCA

The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs [1, 2].

Evolution

OCA is found in most eukaryotes other than eumetazoa. We have seen it in fungi, plants, protists, monosiga, and sponge.

Domain

OCA has a single domain, a phosphatase domain of fold CC1.

Functions

Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].

References

Error fetching PMID 11408586:
Error fetching PMID 15020461:
Error fetching PMID 17976645:
Error fetching PMID 21409566:
Error fetching PMID 18845848:
Error fetching PMID 18166280:
  1. Error fetching PMID 17976645: [Pulido07]
  2. Error fetching PMID 21409566: [Pulido11]
  3. Error fetching PMID 11408586: [Alic]
  4. Error fetching PMID 18845848: [lydall08]
  5. Error fetching PMID 15020461: [Care]
  6. Error fetching PMID 18166280: [Harashima08]
All Medline abstracts: PubMed | HubMed
Retrieved from "http://phosphatome.net/wiki/index.php?title=Phosphatase_Family_OCA&oldid=1577"