Phosphatase Family OCA

Phosphatase Classification: Fold CC1: Superfamily CC1: OCA

The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs [1, 2].

Evolution

OCA is found in most eukaryotes other than eumetazoa. We have seen it in fungi, plants, protists, monosiga, and sponge.

Domain

OCA has a single domain, a phosphatase domain of fold CC1.

Functions

Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].

References

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