Phosphatase Subfamily INPP5F

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily INPP5F (SAC2)

INPP5F (SAC2) is a phosphoinositide phosphatase in the endocytic pathway. It is conserved in metazoa and fungi and is also found in a few plants and basal eukaryotes.

Evolution

The INPP5F (SAC2) subfamily is found in most metazoa and fungi. It is also found in a few plants and basal eukaryotes (see gOrtholog database (internal)).

Domain

The INPP5F (SAC2) subfamily has two structural domain, SAC phosphatase domain and 5-phosphatase domain. It also has a C-terminal proline-rich region [1].

Function

Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see GTEx). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)[2]. It also has 4-phosphatase activity toward PI(4,5)P2) in the endocytic pathway [3, 4]. It cooperates with OCRL, a 5-phosphatase, in the sequential dephosphorylation of PI(4,5)P2 at the 4 and 5 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin [3].

References

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