Phosphatase Subfamily CDC14

Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily CDC14

CDC14 subfamily consists of cell cycle genes widely found in eukaryotes with the exception of higher plants.

Evolution

CDC14 is found in most eukaryotes with the exception of higher plants. Most vertebrates express two paralogs typically designated CDC14A and CDC14B (see unpublished data from gOrtholog).

Domain

CDC14 has two tandem structural equivalent domains linked by an alpha helix. Both domains have a DSP fold and the second domain is catalytic active. CDC14 also has a conserved nuclear export sequence (NES) at C-terminal; human CDC14s has nucleolar targeting sequence at N-terminal [1].

Function

Unlike the budding yeast enzyme, Cdc14 orthologs of most other species are not required for mitotic exit [2, 3]. In vertebrates, there are conflicting reports on the functions of the Cdc14 isoforms, but there is evidence for involvement in regulating mitotic entry, centrosome duplication, DNA repair, and cytokinesis [2, 3].

References

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