Phosphatase Subfamily cf60

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Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: cf60

Cf60 is cellular slime mold specific.

Evolution

Cf60 is cellular slime molds specific.

Domain

Cf60 has single domain, a HP2 phosphatase domain. It also has a signal peptide cleavage site.

Catalytic activity and functions

Cf60 is a component of a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using. Recombinant CF60 does not have acid phosphatase activity [1].

References

  1. Brock DA, van Egmond WN, Shamoo Y, Hatton RD, and Gomer RH. A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum. Eukaryot Cell. 2006 Sep;5(9):1532-8. DOI:10.1128/EC.00169-06 | PubMed ID:16963635 | HubMed [brock06]
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