Phosphatase Subfamily MINPP1

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: MINPP1

MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan.

Evolution

MINPP1 is found broadly in eukaryotes but absent from many genomes, such as C elegans. Human has a single copy, but yeast have as many as five copies.

Domain

MINPP1 has a phosphatase domain, N-terminal signal peptide, and C-terminal ADEL similar to KDEL, the ER-retention signal.

Functions

Human MIPP1 does not display any phosphoglycerate mutase activity. MINPP1 is the only hitherto known InsP6 (aka phytate) phosphatase [1] and is involved in cancer metabolism [2]. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) [1, 3].

Human MIPP1 has biologically significant 2,3-BPG phosphatase activity [4]. Dictyostelium Mipp1 also shows 2,3-BPG phosphatase activity in vitro and in vivo [4]. TIGAR of HP2 family also dephosphorylates 2,3-BPG [5].

Yeast has as many as five MINPP1s, including PHO3, PHO5, PHO11, PHO12 and DIA3. The first four have been known to be involved in phosphate metabolism.

References

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