Phosphatase Family HP2
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2
Refer to Pfam ID PF00328 for general information.
Contents
Subfamilies
ACPP
ACPP (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells [1]. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity [2]. ACPP and its paralog ACP2 is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants.
PXYLP1 (ACPL2)
PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [3]. It is widely found in bilateria.
References
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