Phosphatase Subfamily MINPP1

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Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: MINPP1


Evolution

MINPP1 is found broadly in eukaryotes but absent from many genomes, such as C elegans.

Domain

MINPP1 has phosphatase domain and N-terminal signal peptide cleavage site.

Functions

Human MINPP1 is the only hitherto known InsP6 phosphatase. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) [1, 2].

References