Phosphatase Subfamily MINPP1
From PhosphataseWiki
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: MINPP1
Contents
Evolution
MINPP1 is found broadly in eukaryotes but absent from many genomes, such as C elegans.
Domain
MINPP1 has phosphatase domain and N-terminal signal peptide cleavage site.
Functions
Human MINPP1 is the only hitherto known InsP6 phosphatase. It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) [1, 2].
References
- Ali N, Craxton A, and Shears SB. Hepatic Ins(1,3,4,5)P4 3-phosphatase is compartmentalized inside endoplasmic reticulum. J Biol Chem. 1993 Mar 25;268(9):6161-7.
- Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, and Reynolds PR. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Mol Cell Biol. 2000 Sep;20(17):6496-507. DOI:10.1128/MCB.20.17.6496-6507.2000 |
