Phosphatase Subfamily STYX

Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily STYX

STYX is a catalytically inactive phosphatase found in most opisthokonts but lost in nematodes.

Evolution

STYX is found in most opisthokonts but lost in nematodes. Although STYX is not found in Drosophila and budding yeast, it is found in other arthropoda and fungi (unpublished data from gOrtholog).

Domain

DSP23 has a single domain, the phosphatase domain. Actually, it is the shortest within DSP family [1].

Function

STYX is catalytically inactive (pseudophosphatase) [2]. Little is known about its function. STYX localizes to the nucleus, competes with DUSP4 for binding to ERK, and acts as a nuclear anchor that regulates ERK nuclear export [3]. STYX also binds to a testicular RNA-binding protein Crhsp-24. This complex is essential for normal spermiogenesis [4].

References

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