Phosphatase Subfamily DSP14

Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP14

DSP14 is a subfamily emerged in eumetazoan and duplicated in vertebrates. Human has four members, DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28. Little is known about their functions.

Evolution

DSP14 subfamily emerged in eumetazoan and duplicated in vertebrates.

Domain

DSP14 subfamily has a single phosphatase domain.

Function

DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation [1]. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see GTEx).

DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 [2]. USP18 was widely expressed in different tissues as evidenced by RT-PCR [3]. RNA-seq from GTEx shows a high expression in testis and pituitary, and a low expression in skeleton.

DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation [4].

DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from GTEx, but its function is unknown.

References

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