Phosphatase Subfamily SCP

Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily SCP

SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD [1]. See Phosphorylation of RNA polymerase II C-terminal domain.

Evolution

SCP is conserved from yeast to human.

Domain Combination

SCP has a single phosphatase domain of HAD fold.

Functions

Human SCP1 prefers to dephosphorylate pSer5 at CTD [1]. See Phosphorylation of RNA polymerase II C-terminal domain for other CTD phosphatases.

SCP1 also dephosphorylates c-Myc at Serine-62 which affects its stability in cancer cells [2].

References

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Links

Human CTDSP1, CTDSP2, and CTDSPL from NCBI Gene