Phosphatase Subfamily SCP
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily SCP
SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD [1]. See Phosphorylation of RNA polymerase II C-terminal domain.
Evolution
SCP is conserved from yeast to human.
Domain Combination
SCP has a single phosphatase domain of HAD fold.
Functions
Human SCP1 prefers to dephosphorylate pSer5 at CTD [1]. See Phosphorylation of RNA polymerase II C-terminal domain for other CTD phosphatases.
SCP1 also dephosphorylates c-Myc at Serine-62 which affects its stability in cancer cells [2].
References
- Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, and Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 8;24(5):759-770. DOI:10.1016/j.molcel.2006.10.027 |
- Wang W, Liao P, Shen M, Chen T, Chen Y, Li Y, Lin X, Ge X, and Wang P. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. Oncogene. 2016 Jan 28;35(4):491-500. DOI:10.1038/onc.2015.106 |
Links
Human CTDSP1, CTDSP2, and CTDSPL from NCBI Gene
