Phosphatase Subfamily eak
From PhosphataseWiki
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Eak
Contents
Evolution
The eak subfamily is nematode specific. C. elegans has two members eak-6 and sdf-9 (eak-5).
Domain
The eak subfamily has a single structural domain: the phosphatase domain of CC1 fold.
Function
In C. elegant, both members, eak-6 and sdf-9, potentiate AKT-1/PKB signaling. Eak-6 and sdf-9 mutants have similar dauer formation phenotypes. The function seems independent of phosphatase activity, because sdf-9 is predicted to be catalytically inactive given the replacement of cysteine by serine at the Cx5R motif [1].
References
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