Phosphatase Subfamily eak

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Eak

Evolution

The eak subfamily is nematode specific. C. elegans has two members eak-6 and sdf-9 (eak-5).

Domain

The eak subfamily has a single structural domain: the phosphatase domain of CC1 fold.

Function

In C. elegant, both members, eak-6 and sdf-9, potentiate AKT-1/PKB signaling. Eak-6 and sdf-9 mutants have similar dauer formation phenotypes. The function seems independent of phosphatase activity, because sdf-9 is predicted to be catalytically inactive given the replacement of cysteine by serine at the Cx5R motif [1].

References

1. Hu PJ, Xu J, and Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul;2(7):e99. DOI:10.1371/journal.pgen.0020099 |