Phosphatase Subfamily ACP6

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: Subfamily ACP6

Evolution

The ACP6 subfamily is found in holozoa except ecdysozoa.

Function

Human ACP6 is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate [1]. Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through G-protein-coupled receptors pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including the one through ACP6 [1].

References

1. Li J, Dong Y, Lü X, Wang L, Peng W, Zhang XC, and Rao Z. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. Protein Cell. 2013 Jul;4(7):548-61. DOI:10.1007/s13238-013-3031-z |