Phosphatase Subfamily ACP6
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: Subfamily ACP6
Evolution
The ACP6 subfamily is found across holozoa and absent from ecdysozoa. Furthermore, BLASTing human and monosiga ACP6 against NR database showed the closest genes found in ecdysozoa belong to the ACP2 subfamily, so the ACP6 subfamily was indeed lost in ecdysozoa. And interestingly, both Drosophila melanogaster and C. elegans have remarkable expansions in another subfamily in HP1 family ACP2. The ACP6 subfamily is also absent from budding yeast, but reciprocal BLAST and internal orthology database showed many other fungi have ACP6.
Domain
Function
Human ACP6 is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate [1]. Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through G-protein-coupled receptors pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including the one through ACP6 [1].
