Phosphatase Subfamily pats1

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily pats1

Evolution

Dictyostelium discoideum has two myotubularins, pats1 and roco9, diverged from other myotubularins. Both of them have protein kinase domain. They are classified as TKL group, LRRK family in kinase.com. The subfamily is found in amoebazoa. The phosphatase domain is quite diverged from other myotubularins.

Domains

Pats1 contains phosphatase, GTP–binding, protein kinase, 13 leucine-rich repeats, and 8 WD-40 repeats [1].

Functions

Pats1 is required for cytokinesis in Dictyostelium discoideum [1].

References

1. Abysalh JC, Kuchnicki LL, and Larochelle DA. The identification of pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum. Mol Biol Cell. 2003 Jan;14(1):14-25. DOI:10.1091/mbc.e02-06-0335 |