Phosphatase Subfamily PTPRG Functions
Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPRG - Functions
Contents
In-vertebrate PTPRG?
The vertebrate forms are expressed in brain and involved in cell adhesion. Drosophila ptp99a is also selectively expressed and functions in the nervous system, interacting with other RPTPs, including Dlar and ptp69D.
PTPRG
PTPRG is suggested to be a tumor suppressor due to it's frequent loss or decreased expression in a number of cancer types.
The phosphatase activity is modulated by the ligands binding to extracellular region [1] and other proteins binding to the cytoplasmic region [2].
PTPRG has various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques, and a natural soluble protein in plasma has been identified by experimental assays [3].
PTPRZ1 (Rptpζ)
Ptprz1-deficiency significantly enhanced osteosarcoma development with 19% of the mice being affected [4].
PTPRZ1-MET (ZM) fusion protein is identified in human gliomas by high-throughput transcriptome sequencing, which induces gliomas through elevated expression and phosphorylation of the MET oncoprotein [5].
References
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