Phosphatase Subfamily PTPRG Tech Note

Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPRG: Technical notes

The gain of N-terminal Carbonic anhydrase (CA) domain

We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates, in a narrow-down approach. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates.