Phosphatase Fold CC1

Phosphatase Classification: Fold CC1

Fold CC1 has a single superfamily CC1.

Comparing the secondary structure across families

We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).

All CC1 families share the same SSs combination of BBHBBHBHHH (B - sheet, H - helix). The families have different N-terminal SSs. The sheets and helices are inserted at:

• B2-H1: Sac1p
• H1-B3: MTMR2
• B3-B4: PTPN1, MTMR2, Sac1p
• B4-H2: PTPN1, MTMR2
• H2-B5: Sac1p
• H3-H4: MTMR2

MTMR2 has additional 4 helices at C terminus.