Phosphatase Subfamily YMR1

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily YMR1

YMR1 encodes PI(3)P phosphatase found in fungi [1]. It is the single myotubularin in most fungi.

Evolution

YMR1 is found in most fungi.

Domain Structure

YMR1 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.

Catalytic activity and functions

YMR1 of budding yeast encodes PI(3)P phosphatase, so does its ortholog in fission yeast [1, 2].

References

1. Taylor GS, Maehama T, and Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. DOI:10.1073/pnas.160255697 |