Phosphatase Subfamily MTMR1

Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin

CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.

Evolution

CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called CTSDPL2, HSPC058, HSPC129, or SCP4

Domain Structure

Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension

Catalytic activity

Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.

Functions

Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

References

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