Phosphatase Subfamily MTMR1
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: MTMR1
CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.
Evolution
MTMR1 is found throughout holozoan. It consists of three members in human, MTM1, MTMR1 and MTMR2. In fruit fly and C elegans, a single copy is found.
Domain Structure
MTMR1 has a GRAM and phosphatase domain. GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.
Catalytic activity
Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.
Functions
Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
- Qian H, Ji C, Zhao S, Chen J, Jiang M, Zhang Y, Yan M, Zheng D, Sun Y, Xie Y, and Mao Y. Expression and characterization of HSPC129, a RNA polymerase II C-terminal domain phosphatase. Mol Cell Biochem. 2007 Sep;303(1-2):183-8. DOI:10.1007/s11010-007-9472-z |
- Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, and Lin X. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26441-26450. DOI:10.1074/jbc.M114.568964 |
