Phosphatase Subfamily MTMR3

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Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: MTMR3

MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P].

Evolution

MTMR1 is in metazoan. It consists of two members in human, MTMR3 and MTMR4. In fruit fly and C elegans, a single copy is found.

Domain Structure

MTMR3 subfamily has a conserved domain combination: phosphatase domain and FYVE domain, which can bind to the second messenger phosphatidylinositol 3-monophosphate PI3P.

Catalytic activity and functions

Human MTMR3

Related Kinases

See PI3K.


References

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  1. Error fetching PMID 11001925: [blondeau00]
  2. Error fetching PMID 10900271: [taylor00]
  3. Error fetching PMID 12217958: [bujbell02]
  4. Error fetching PMID 11733541: [kim01]
All Medline abstracts: PubMed | HubMed
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