Phosphatase Subfamily MTMR3
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: MTMR3
MTMR1 is a lipid phosphatase that dephosphorylates the second messenger phosphatidylinositol 3-monophosphate [PI(3)P].
Evolution
MTMR1 is in metazoan. It consists of two members in human, MTMR3 and MTMR4. In fruit fly and C elegans, a single copy is found.
Domain Structure
MTMR3 subfamily has a conserved domain combination: a divergent PH/GRAM domain, an active phosphatase domain and an atypical FYVE domain. It has been shown that the FYVE domain of MTMR3 is atypical in that it neither confers endosomal localisation nor binds to the lipid PtdIns3P. Furthermore it is not required for in vitro enzyme activity of MTMR3. In contrast, the PH/GRAM domain is able to bind to phosphoinositide lipids [1].
Catalytic activity and functions
Human MTMR3 is an inositol lipid 3-phosphatase, with a so-far-unique substrate specificity. It is able to hydrolyze PtdIns3P and PtdIns(3,5)P2, both in vitro and when heterologously expressed in S. cerevisiae. Thus, MTMR3 plays critical role in the cellular production of PtdIns5P [2].
Related Kinases
See PI3K.
