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Welcome to Phosphatase Wiki, a resource for of phosphatases and phosphatase signaling. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wiki's, just go to the login page to request an account.

Introduction to Phosphatases

Protein Phosphatase Classification and Evolution

Classification chart

In contrast with kinases, there are multiple folds of protein phosphatases, which means protein phosphatases have multiple independent evolutionary origins, while most kinases have a single origin. We classified protein phosphatases into a hierarchy scheme of four levels: fold, superfamily, family and subfamily.

Catalytically inactive phosphatases (pseudophosphatases)

Protein phosphatases have various functions. Some protein phosphatases lack catalytically activity, although most of them play critical roles in various cellular signaling pathways.

Protein phosphatase evolution
Human protein phosphatase pseudogenes

Glossary

Technical notes