Difference between revisions of "Phosphatase Family HP2"

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(PXYLP1)
(ACPP)
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=== Subfamilies ===
 
=== Subfamilies ===
  
====== ACPP ======
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====== [[Phosphatase_Subfamily_ACP2|Subfamily ACP2]] ======
[http://www.ncbi.nlm.nih.gov/gene/55 ACPP] (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells <cite>ACPP_2</cite>. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity <cite>ACPP_1</cite>. ACPP and its paralog [http://www.ncbi.nlm.nih.gov/gene/53 ACP2] is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants.
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====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) ======
 
====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) ======

Revision as of 22:16, 1 January 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2

Refer to Pfam ID PF00328 for general information.

Subfamilies

Subfamily ACP2
PXYLP1 (ACPL2)

PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.

References

  1. Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 | PubMed ID:24425863 | HubMed [koike14]
  2. Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 | PubMed ID:11067847 | HubMed [ACPP_1]
  3. Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104. DOI:10.1074/jbc.273.34.22096 | PubMed ID:9705354 | HubMed [ACPP_2]
All Medline abstracts: PubMed | HubMed