Phosphatase Family NagD

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Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD

The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:

  • PGP is ubiquitous in eukaryotes. The two members in human have distinct functions: PGP is a putative tyrosine-specific protein phosphatase, and PDXP (chronophin) dephosphorylates cofilin on serine, and also dephosphorylates pyridoxal 5'-phosphate. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.
  • LHPP is a protein histidine phosphatase subfamily conserved in holozoa.
  • CUT is a mitochondrial-associated probable non-protein phosphatase.