Difference between revisions of "Phosphatase Family PAP"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]:[[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PAP|Family PAP]] (purple acid phosphatase)
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PAP|Family PAP]] (purple acid phosphatase)
  
PAP is short for purple acid phosphatase. It has two subfamilies present in human:
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PAP ('''P'''urple '''A'''cid '''P'''hosphatase is found in most eukaryotes, even in some prokaryotes. It has three eukaryotic subfamilies, the first two present in human:
  
* [[Phosphatase_Subfamily_ACP5|ACP5]]. ACP5 subfamily is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acid pH in vitro. It also show phosphatase activity towards protein osteopontin, and mannose 6-phosphate modification on lysosomal proteins.
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* [[Phosphatase_Subfamily_ACP5|ACP5]] is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acidic pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.
  
* [[Phosphatase_Subfamily_PAPL|PAPL]].
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* [[Phosphatase_Subfamily_PAPL|PAPL]] is found in holozoa, but is lost in most arthropods. Its function is unclear.
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* [[Phosphatase_Subfamily_DCR2|DCR2]] is present in most fungi, most plants and some chromalveolates.

Latest revision as of 00:56, 9 May 2016

Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP (purple acid phosphatase)

PAP (Purple Acid Phosphatase is found in most eukaryotes, even in some prokaryotes. It has three eukaryotic subfamilies, the first two present in human:

  • ACP5 is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acidic pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.
  • PAPL is found in holozoa, but is lost in most arthropods. Its function is unclear.
  • DCR2 is present in most fungi, most plants and some chromalveolates.