Phosphatase Family PAP

Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP (purple acid phosphatase)

PAP is short for purple acid phosphatase. The family is found in most eukaryotes, even in some prokaryotes. It has two subfamilies present in human:

• ACP5. ACP5 subfamily is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acid pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.

• PAPL. PAPL is found in holozoa, but is lost in most arthropods. Its function is unclear.

Besides, DCR2 subfamily is present in most fungi, most plants and some chromalveolata (internal data from gOrtholog database).