Difference between revisions of "Phosphatase Family Paladin"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Paladin|Family Paladin]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]:  [[Phosphatase_Family_Paladin|Family Paladin]]
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The phosphatase family Paladin has one [[Phosphatase_Subamily_Paladin|subfamily Paladin]].
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=== Evolution ===
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Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database [http://resdev.gene.com/gOrtholog/view/cluster/MC0005718/overview gOrtholog]).
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=== Domain ===
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The Paladin subfamily has a single domain, which lacks the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases.
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=== Function ===
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Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken <cite>Roffers-Agarwal12</cite>, but it lacks the residue necessary for phosphatase activity.
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=== References ===
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<biblio>
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#Roffers-Agarwal12 pmid=22926139
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</biblio>

Revision as of 21:53, 14 April 2015

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Paladin

The phosphatase family Paladin has one subfamily Paladin.

Evolution

Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database gOrtholog).

Domain

The Paladin subfamily has a single domain, which lacks the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases.

Function

Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken [1], but it lacks the residue necessary for phosphatase activity.

References

  1. Roffers-Agarwal J, Hutt KJ, and Gammill LS. Paladin is an antiphosphatase that regulates neural crest cell formation and migration. Dev Biol. 2012 Nov 15;371(2):180-90. DOI:10.1016/j.ydbio.2012.08.007 | PubMed ID:22926139 | HubMed [Roffers-Agarwal12]