Phosphatase Family Paladin
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Paladin
The phosphatase family Paladin has one subfamily Paladin.
Evolution
Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database gOrtholog).
Domain
The Paladin subfamily has two domains of CC1 fold, both of which lack the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases.
Function
Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken [1], but it lacks the residue necessary for phosphatase activity.
Human Paladin is widely expressed in different tissues according to GTEx.
