Difference between revisions of "Phosphatase Family Sac"

Revision as of 18:28, 15 April 2015

The Sac family has four subfamilies:

SAC1 - an integral membrane phosphoinositide phosphatase located in endoplasmic reticulum (ER) and golgi apparatus. Its substrate in vivo is phosphatidylinositol 4-phosphate (PtdIns4P), and it is also able to dephosphorylate other phosphoinositides in vitro. SAC1 is conserved in eukaryotes.
INPP5F
FIG4 (SAC3) - a phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) phosphatase located in the vacuolar membrane. It is associated with a form of Charcot-Marie-Tooth disorder CMT4J, Yunis-Varón syndrome, and amyotrophic lateral sclerosis (ALS). FIG4 is found in most if not all eukaryotes.
Synaptojanin

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 The Sac family has four subfamilies:
-* [[Phosphatase_Subfamily_SAC1|SAC1]] - an integral membrane phosphoinositide phosphatase located in endoplasmic reticulum (ER) and golgi apparatus. SAC1 is conserved in eukaryotes.
+* [[Phosphatase_Subfamily_SAC1|SAC1]] - an integral membrane phosphoinositide phosphatase located in endoplasmic reticulum (ER) and golgi apparatus. Its substrate in vivo is phosphatidylinositol 4-phosphate (PtdIns4P), and it is also able to dephosphorylate other phosphoinositides in vitro. SAC1 is conserved in eukaryotes.
 * [[Phosphatase_Subfamily_INPP5F|INPP5F]]
 * [[Phosphatase_Subfamily_FIG4|FIG4]] (SAC3) - a phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)  phosphatase located in the vacuolar membrane. It is associated with a form of Charcot-Marie-Tooth disorder CMT4J, Yunis-Varón syndrome, and amyotrophic lateral sclerosis (ALS). FIG4 is found in most if not all eukaryotes.
 * [[Phosphatase_Subfamily_Synaptojanin|Synaptojanin]]