Phosphatase Subfamily CDC14
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily CDC14
CDC14 subfamily consists of cell cycle genes widely found in eukaryotes with the exception of higher plants.
Evolution
CDC14 is found in most eukaryotes with the exception of higher plants. Most vertebrates express two paralogs typically designated CDC14A and CDC14B (see unpublished data from gOrtholog).
Domain
CDC14 has a conserved domain combination: N-terminal phosphatase domain and nuclear export sequence (NES) [1].
Function
Unlike the budding yeast enzyme, Cdc14 orthologs of most other species are not required for mitotic exit [1, 2]. In vertebrates, there are conflicting reports on the functions of the Cdc14 isoforms, but there is evidence for involvement in regulating mitotic entry, centrosome duplication, DNA repair, and cytokinesis [1, 2].
References
- Mocciaro A and Schiebel E. Cdc14: a highly conserved family of phosphatases with non-conserved functions?. J Cell Sci. 2010 Sep 1;123(Pt 17):2867-76. DOI:10.1242/jcs.074815 |
- Bremmer SC, Hall H, Martinez JS, Eissler CL, Hinrichsen TH, Rossie S, Parker LL, Hall MC, and Charbonneau H. Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine. J Biol Chem. 2012 Jan 13;287(3):1662-9. DOI:10.1074/jbc.M111.281105 |
