Difference between revisions of "Phosphatase Subfamily LHPP"

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(Created page with "__NOTOC__ Phosphatase Classification: HAD: NagD: HDHD2 ...")
 
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__NOTOC__
 
__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Group_HAD|HAD]]: [[Phosphatase_Family_NagD|NagD]]: [[Phosphatase_Subfamily_HDHD2|HDHD2]]
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_LHPP|Subfamily LHPP]]
  
HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied. A related protein, LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate two proteins on hisitidine and also has activity against free phospho-lysine and phospho-histidine amino acids  <cite>Hiraishi</cite>.
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LHPP is a protein histidine phosphatase conserved in holozoan.
 
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== Evolution ==
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Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks an LHPP gene and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi, oomycetes and choanoflagellates also have a family member, which is generally closer to HDHD2 in sequence. A small number of bacterial homologs are also found.
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=== Evolution ===
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LHPP subfamily is conserved in holozoan. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks an LHPP gene and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi and oomycetes also have HDHD2-like genes. HDHD2-like genes are also found in a small number of bacteria.
  
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=== Function ===
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LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids  <cite>Hiraishi</cite>.
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HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied.
  
 
== References ==
 
== References ==

Revision as of 04:54, 9 March 2015

Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily LHPP

LHPP is a protein histidine phosphatase conserved in holozoan.

Evolution

LHPP subfamily is conserved in holozoan. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks an LHPP gene and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi and oomycetes also have HDHD2-like genes. HDHD2-like genes are also found in a small number of bacteria.

Function

LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids [1]. HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied.

References

  1. Hiraishi H, Yokoi F, and Kumon A. Bovine liver phosphoamidase as a protein histidine/lysine phosphatase. J Biochem. 1999 Aug;126(2):368-74. DOI:10.1093/oxfordjournals.jbchem.a022459 | PubMed ID:10423531 | HubMed [Hiraishi]