Difference between revisions of "Phosphatase Subfamily MTMR5"

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Human MTMR5 interact with MTMR2 (see [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]]) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization <cite>kim03</cite>. This is a good example of inactive phosphatase functions as regulator of active phosphatase.
 
Human MTMR5 interact with MTMR2 (see [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]]) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization <cite>kim03</cite>. This is a good example of inactive phosphatase functions as regulator of active phosphatase.
  
 
+
===Disease===
 +
Mice deficient for MTMR5 exhibited male infertility characterized by azoospermia <cite>firestein02</cite>.
  
 
===References===
 
===References===
 
<biblio>
 
<biblio>
 
#kim03 pmid=12668758
 
#kim03 pmid=12668758
 +
#firestein pmid=11994405
 
</biblio>
 
</biblio>

Revision as of 23:59, 30 December 2014


Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR5 (SBF)

[a punch line at here]

Evolution

MTMR5 subfamily is found throughout metazoan. It consists of two members in human, MTMR5 and MTMR13, also called SBF1 and SBF2, respectively. In fruit fly and C elegans, a single copy is found.

Domain Structure

MTMR5 subfamily has a DENN domain, PH/GRAM domain, phosphatase domain, coiled-coil domain and PH domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.

Catalytic activity and functions

MTMR5 subfamily is conservatively inactive in metazoan.

Human MTMR5 interact with MTMR2 (see MTMR1 subfamily) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization [1]. This is a good example of inactive phosphatase functions as regulator of active phosphatase.

Disease

Mice deficient for MTMR5 exhibited male infertility characterized by azoospermia [2].

References

  1. Kim SA, Vacratsis PO, Firestein R, Cleary ML, and Dixon JE. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4492-7. DOI:10.1073/pnas.0431052100 | PubMed ID:12668758 | HubMed [kim03]
  2. Firestein R, Nagy PL, Daly M, Huie P, Conti M, and Cleary ML. Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest. 2002 May;109(9):1165-72. DOI:10.1172/JCI12589 | PubMed ID:11994405 | HubMed [firestein]
All Medline abstracts: PubMed | HubMed