Phosphatase Subfamily PTPN1

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRG

Two copies in human, PTPN1 (PTP1B) and PTPN2. It contains a single phosphatase domain. They dephoshorylate kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). The phosphatase emerged later than the related kinases. The phosphatase first emerged in Trichoplax. EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human.