Difference between revisions of "Phosphatase Subfamily YMR1"

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===Catalytic activity and functions===
 
===Catalytic activity and functions===
YMR1 encodes PI(3)P phosphatase <cite>taylor00</cite>.
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YMR1 of budding yeast encodes PI(3)P phosphatase, so does its ortholog in fission yeast  <cite>taylor00, blondeau00</cite>.
  
 
===References===
 
===References===

Revision as of 14:56, 9 September 2016


Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily YMR1

YMR1 encodes PI(3)P phosphatase found in fungi [1]. It is the single myotubularin in most fungi.

Evolution

YMR1 is found in most fungi.

Domain Structure

YMR1 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.

Catalytic activity and functions

YMR1 of budding yeast encodes PI(3)P phosphatase, so does its ortholog in fission yeast [1, 2].

References

  1. Taylor GS, Maehama T, and Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. DOI:10.1073/pnas.160255697 | PubMed ID:10900271 | HubMed [taylor00]