Difference between revisions of "Phosphatase Superfamily HAD"

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[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]
 
[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]
 
  
 
The HAD (HaloAcid Dehalogenase) superfamily contains an array of different hydrolase enzymes, including several that are known to have protein phosphatase or other phosphatase activites <cite>Koonin, Burroughs</cite>. The following HAD families have reported protein phosphatase activity:
 
The HAD (HaloAcid Dehalogenase) superfamily contains an array of different hydrolase enzymes, including several that are known to have protein phosphatase or other phosphatase activites <cite>Koonin, Burroughs</cite>. The following HAD families have reported protein phosphatase activity:
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* [[Phosphatase_Family_MDP1|MDP1 family]] has been removed from protein phosphatase, because it is protein-fructosamine-6-phosphatase evidenced by experimental assays.
 
* [[Phosphatase_Family_MDP1|MDP1 family]] has been removed from protein phosphatase, because it is protein-fructosamine-6-phosphatase evidenced by experimental assays.
 
  
 
=== References ===
 
=== References ===

Revision as of 23:56, 22 March 2015

Phosphatase Classification: Fold HAD: Superfamily HAD

The HAD (HaloAcid Dehalogenase) superfamily contains an array of different hydrolase enzymes, including several that are known to have protein phosphatase or other phosphatase activites [1, 2]. The following HAD families have reported protein phosphatase activity:

  • MDP1 family has been removed from protein phosphatase, because it is protein-fructosamine-6-phosphatase evidenced by experimental assays.

References

  1. Koonin EV and Tatusov RL. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol. 1994 Nov 18;244(1):125-32. DOI:10.1006/jmbi.1994.1711 | PubMed ID:7966317 | HubMed [Koonin]
  2. Burroughs AM, Allen KN, Dunaway-Mariano D, and Aravind L. Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol. 2006 Sep 1;361(5):1003-34. DOI:10.1016/j.jmb.2006.06.049 | PubMed ID:16889794 | HubMed [Burroughs]
  3. Fortpied J, Maliekal P, Vertommen D, and Van Schaftingen E. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. J Biol Chem. 2006 Jul 7;281(27):18378-85. DOI:10.1074/jbc.M513208200 | PubMed ID:16670083 | HubMed [Fortpied06]
All Medline abstracts: PubMed | HubMed