Gene CDC14 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP001_AA protein Get Run
AqueP001_AA_7-151 phosphatase_domain Get Run
AqueP001_AA_170-253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Glyco_transf_29 Glycosyltransferase family 29 (sialyltransferase) 6-68 9.2e-06 11.3 Pfam-A 207-262 (266) alignment 
Range on Protein: 6-68
Range on HMM: 207-262/266.0
CSIIDRLYFATlrsRPRNSSSCHYFSS-DDEYVYENFYldfgpHNLATLFRYCQRLHKKLKSQS
|  ..   | .     |.. ..||...  .... |. .     |.|.. ... |||||. . . 
CdeVsvyGFga...sdrkknwhhYydnvknkastefak.....HdldyEaqllqrLhkagvikl
subfamily_CDC14_pd Subfamily CDC14 8-254 1e-123 407.4 In-house 7-253 (328) alignment 
Range on Protein: 8-254
Range on HMM: 7-253/328.0
IIDRLYFATLRSRPRNSSSCHYFSSDDEYVYENFYLDFGPHNLATLFRYCQRLHKKLKSQSLARKKIIHYTSYDSRRRANAAYLIGCYVIIYHKKTPDEA
. |||||||||..|...|..|||| |||..||||| ||||.|||.|.|||..|.|||||.. |.|||..|||.||..|||||.|||.|..||.|||..||
ledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkktaeea

FRPLAAAQNPPFQPFRDAAMGPCTYNLTLQHCFQAVHKALQFGFLDFSQFNVEEYEHYERVENGDLNWIVPGKFLAFAGPHNKSRIEQGYPLHAPEFYFP
.|.|.||..|||.|||||..|...|.|||......|.||||.||||...|..||||.||||||||.|||||.||||.|||||||..|.|||||||| ...
yraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaPeklle

YFRHYKVSTIVRLNKRLYDAQRFIDGGFDHKDLFFVDGSTPSDTIVK
|||...|.|.|||||.||||..| | |||||||||.|||||||.|||
yfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivk
DSPn Dual specificity protein phosphatase, N-terminal half 8-146 8.3e-58 185.1 Pfam-A 4-141 (141) alignment 
Range on Protein: 8-146
Range on HMM: 4-141/141.0
IIDRLYFATLRSRPRNSSSCHYFSSDDEYVYENFYLDFGPHNLATLFRYCQRLHKKLKSQSLARKKIIHYTSYDSRRRANAAYLIGCYVIIYHKKTPDEA
| |||||..|...|..... |||| |.|.|||.|| |||| ||| ..|.|..|.||||...|..|||..|||.|...|||||.|||.|..|..|..|.||
iedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeea

FRPLAAAQnPPFQPFRDAAMGPCTYNLTLQHCFQAVHKA
..||.... |...|||||..|..||.||...|.....||
lkplesve.psllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 8-154 8.5e-52 169.4 In-house 11-156 (157) alignment 
Range on Protein: 8-154
Range on HMM: 11-156/157.0
IIDRLYFATLRSRPRNSSSCHYFSSDDEYVYENFYLDFGPHNLATLFRYCQRLHKKLKSQSLARKKIIHYTSYDSRRRANAAYLIGCYVIIYHKKTPDEA
| ||||||.|.. |..  ...||| ||..|||.|. |||| |||.|.|....|.|.||. .||.|.|....... ..|...|.||||| |.....||.||
ipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeea

FRPLaAAQNPPFQPFRDAAMGPCTYNLTLQHCFQAVHKALQFGFLDF
..|| .  .|...||||| .....|||||........|||..||||.
iapl.rivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldl
0050432 (Phosphotyrosine protein) phosphatases II 116-250 3.6e-15 51.5 In-house 8-215 (308) alignment 
Range on Protein: 116-250
Range on HMM: 8-215/308.0
NPPFQPFRDAAMGPCTYNLTLQHCFQAVHKALQFGFLD------FSQFNVEEYEHYERVENGDLNW-------------------------------IVP
 .....|||. . .....|..... ... |||..|.|.      .|.....||......||.|.|.                               ..|
llelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklp

GKFLAFAGPHnksrieqgypLHAPEFYFPYFRHYKVSTIVRLNKRLYD-----AQRFIDG---GFDHKDLFFV---------------------------
 ||.|. ||.           .  | .. .. ...|..||.|.|  ..     || . .    |. . . |.|                           
rkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

-----------DGSTPSD
           |...|..
tvthfhytnWpdhgvPps
0045450 (Phosphotyrosine protein) phosphatases II 116-249 2.2e-11 39.6 In-house 2-212 (307) alignment 
Range on Protein: 116-249
Range on HMM: 2-212/307.0
NPPFQPFRDAAMGPCTYNLTLQHCFQAVHKALQfGFLDFSQFNVEEYEHYERVENGDLNWI---------------------------------------
..|. .|.|| .. . ..|.|. ... ..|. .  .|..  | . ||......||.|.|..                                       
dlplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplllll

----VPGKFLAFAGPHNKsrieqgyplhAPEFYFPYFRHYKVSTIVRLNKRLYDAQR------------------------------------------F
    .. ||.|. ||...           .| .. ......|..||.|..  .....                                          .
dgydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldg

IDGGFDHKDLFF---VDGSTPS
 . .. .. ...    |...|.
tgesrtvthfhytgwpdhgvpp
0049772 (Phosphotyrosine protein) phosphatases II 118-252 2.4e-15 52.5 In-house 65-198 (314) alignment 
Range on Protein: 118-252
Range on HMM: 65-198/314.0
PFQPFRDAAMGPCTYNLTLQHCFQAVHKaLQFGFLDFSQFNVEEYEHYERVENGDLNWIVPGK---------------------FLAFAGPHnksrieqg
|..|... ..  . |  . . . .. .. |. .. ||....| .|.....|..||||......                     .| . |..        
pglpvsgsdyinasyvdgflkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........

yplhaPEFYFPYFRHYKvstivrlnKRLYDAQRFIDGGFDHKDLFFVDGSTPSDTI
     .|  . .. ..|        ..|||...| . |. .... . |||.|.. .
.....neptaadlellk........eelydpelferlgikylripvpDgsaplled
0039614 (Phosphotyrosine protein) phosphatases II 120-228 1.3e-11 40.0 In-house 2-140 (297) alignment 
Range on Protein: 120-228
Range on HMM: 2-140/297.0
QPFRDAAMGPCTYNLTLQHCFQAVHKALQFGFLDFSQFNV----EEYEHYERVENGDLNWIV------------------------------------PG
 |.|||....... |. ..... ..||.....|.   ...    ..|......||.|.|...                                    . 
lplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

KFLAFAGPHNKsrieqgyplhAPEFYFPYFRHYKVSTIVRLNKRLYDAQ
||.|. ||...           .| .. ......|..||.|.|  .. .
kfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgr
0043336 (Phosphotyrosine protein) phosphatases II 128-250 5.5e-12 41.2 In-house 3-191 (278) alignment 
Range on Protein: 128-250
Range on HMM: 3-191/278.0
GPCTYNLTLQHCFQAVHKALQFGFLDFSQFNVEEYEHYERVENGDLNWIV----------------------------------PGKFLAFAGPHNKsri
. ...  .|.... .....|. .| .. .|....|......||.|.|...                                  | ||.|. ||...   
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

eqgyplhAPEFYFPYFRHYKVSTIVRLNKRL--------------------------------------------YDAQRFIDGGFDHKDLFfvDGSTPS
        .| .. ......|.|||.|..                                              .| . ..  .. ...    |...|.
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpe

D
.
s
0040438 (Phosphotyrosine protein) phosphatases II 129-248 1.9e-12 42.6 In-house 2-188 (317) alignment 
Range on Protein: 129-248
Range on HMM: 2-188/317.0
PCTYNLTLQHCFQAVHKALQFGFLDFSQFNVEEYEHYERVENGDLNWIV----------------------------------PGKFLAFAGPHNKsrie
.. ..|.|. ...  ..||. .| |. ......|...|..||.|.|...                                  . ||.|. ||...    
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn....

qgyplhAPEFYFPYFRHYKVSTIVRLNKRLYD------------------------AQRFIDGGFDHKDLFF-------------------VDGSTP
        | .. .. ...|..||.|..  ..                         . . ..|. .  | .                    |...|
......tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvp
0045098 (Phosphotyrosine protein) phosphatases II 142-253 5.4e-10 34.6 In-house 5-175 (278) alignment 
Range on Protein: 142-253
Range on HMM: 5-175/278.0
AVHKALQFGFLDFSQFNVEEYEHYERVENGDLNWIV----------------------PGKFLAFAGPHNksrieqgyplHAPEFYFPYFRHYKVSTIVR
|. ..|. ..  ...... |.... ...|.|.|...                      | ||.|..||..          .  . .. .........||.
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivm

LNKRLYDA----------------------------------------------QRFIDGGFDHKDL-FFVDGSTPSDTIV
|.. ....                                              . .   |. | .. .. |...||..|.
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpil
0044763 (Phosphotyrosine protein) phosphatases II 152-249 7.1e-10 34.3 In-house 2-90 (178) alignment 
Range on Protein: 152-249
Range on HMM: 2-90/178.0
LDFSQFNVEEYEHYERVENGDLNWIVPGKFLAFAGPhnksrieqgyplhapEFYFPYFRHYKVSTIVRLNKRLY------DAQRFIDGGFDHKDLFFVDG
||.. ......|..||... ....|.|| .|. ..|               . ...... .....||.|.. |.      |.. . . |. .. . ..|.
ldrtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDh

STPS
..|.
gvpd
0041856 (Phosphotyrosine protein) phosphatases II 157-249 1.8e-12 42.7 In-house 2-94 (182) alignment 
Range on Protein: 157-249
Range on HMM: 2-94/182.0
FNVEEYEHYERVENGDLNWIVPGKFLAFAGPHNKSRIEQGYPLHAPEFYFPYFRHYKVSTIVRLNKRLYDAQRFIDGGFDHKDLFFVDGSTPS
.. ..|... .....  .. .  ...... |...  . ||..|. .. ...........|||.|. .||..... . |. ...|.. |...|.
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd
0038934 (Phosphotyrosine protein) phosphatases II 160-253 1.6e-13 46.3 In-house 4-99 (194) alignment 
Range on Protein: 160-253
Range on HMM: 4-99/194.0
EEYEHYERVENgdlnwIVPGKFLAFAGPHNKSRIEQGYPLH--APEFYFPYF--RHYKVSTIVRLN--KRLYDAQRFIDGGFDHKDLFFVD-GSTPSDTI
.....||||..     |..|.|.||..|...|  .. ..|.  .||... |.  ...|. ....|.  .|.||...| . |... .|.|.| |..||. |
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

V
.
l
0043147 (Phosphotyrosine protein) phosphatases II 160-251 1.8e-08 29.8 In-house 2-82 (172) alignment 
Range on Protein: 160-251
Range on HMM: 2-82/172.0
EEYEHYERVENGDLNWiVPGKFLAFAGPhnksrieqgyPLHAPEFYFPYFRHYKVSTIVRLNKRLYDAQRFIDGGFDHKDLFFVDGSTPSDT
.|...|..... ||.. .| .|.|. ||            .  . .. .........||.|...|||.. . . |. .  | . |...|.  
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvplle
0040439 (Phosphotyrosine protein) phosphatases II 161-250 5e-06 21.8 In-house 2-158 (249) alignment 
Range on Protein: 161-250
Range on HMM: 2-158/249.0
EYEHYERVENGDLNWIV----------------------------------PGKFLAFAGPHNKsrieqgyplhAPEFYFPYFRHYKVSTIVRLNKRL--
||......||.|.|...                                  . .|.|. || ..          . | .. .........||.|..    
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDAQRFIDGGFDHKDLFfvDGSTPSD
                                           || . .   .. . |.   | ..|..
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvpps
0036282 (Phosphotyrosine protein) phosphatases II 164-252 3e-06 22.5 In-house 3-87 (174) alignment 
Range on Protein: 164-252
Range on HMM: 3-87/174.0
HYERVENGDLNWIVPgKFLAFAGPHNksrieqgyplhapefYFPYFRHYKVSTIVRLNKRLYDA------------QRFIDGGFDHKDLFFVDGSTPSDT
.|... . ||..| | ...|..||..               ...........|.|.|..  ..             . . . |. ...| ..|...|...
dyinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdls

I
|
i
0048567 (Phosphotyrosine protein) phosphatases II 168-229 8.7e-08 26.7 In-house 2-68 (157) alignment 
Range on Protein: 168-229
Range on HMM: 2-68/157.0
VENGDLNWIVPGKFLAFAGPHNKSRIEQGYPLHAPE--FYFPYFRHY---KVSTIVRLNKRLYDAQR
.|||||..|.|........|. ...... .... ..  .|...|. .   ......|....|..  .
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflk
0051082 (Phosphotyrosine protein) phosphatases II 172-250 3.4e-06 22.3 In-house 7-73 (151) alignment 
Range on Protein: 172-250
Range on HMM: 7-73/151.0
DLNWIVPGkFLAFAGPHNksrieqgyplhapeFYFPYFRHYKVSTIVRLNKRL---YDAQRFIDGGFDHKDLFFVDGSTPSD
..... .| .....||..               ...........||| |..     |..... . |...... ..| ..|. 
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpgl
0049260 (Phosphotyrosine protein) phosphatases II 185-252 1.2e-06 23.8 In-house 5-72 (152) alignment 
Range on Protein: 185-252
Range on HMM: 5-72/152.0
AGPHNKSRIEQGYPLHAPEFYFPYFRHYKVSTIVRLNKRLYDAQRFIDGGFDHKDLFFVDGSTPSDTI
 .....  . ||.  .  . .. ........|||.|...|...  . . .. .. |.. |...|....
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsq
subfamily_PRL_pd Subfamily PRL 205-254 6.6e-06 20.3 In-house 26-75 (151) alignment 
Range on Protein: 205-254
Range on HMM: 26-75/151.0
YFPYFRHYKVSTIVRLNKRLYDAQRFIDGGFDHKDLFFVDGSTPSDTIVK
.   .....|.|.||  .  ||.. . . | . .|| | ||..|.. .|.
fieelkkeevktvvrvceptydteklekegievldlafddGavPpeevve