Gene AqueDSP-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP002_AA protein Get Run
AqueP002_AA_80-231 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 70-229 6.7e-16 53.7 In-house 27-193 (196) alignment
Range on Protein: 70-229
Range on HMM: 27-193/196.0
SRLSKHTSFYEMV--DasEINTYLLIGNQPSV-ENTEFLSRKRILFVLNLSNSPVP---------VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKA
||........ .   .  ||   |..|....| .. . |  . | .|.|||. .             . |.||...  ||.   .|  ..  | .| . .
sriiamgkapsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewl

KKKCEsnkGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYN
... .   |  |||.   ||.||. |. | ||. ...| .. . ..... | . || ... .||||. .| .
lsdpn...gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella

0044763 (Phosphotyrosine protein) phosphatases II 75-229 4.2e-32 106.6 In-house 14-172 (178) alignment
Range on Protein: 75-229
Range on HMM: 14-172/178.0
HTSFYEMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN---------SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkceSNK
..  ... .||||  .|..|..|.... |.| .  |  ..||..          |  ... ||.|. . ..|... |||  ......|...|     ..|
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal....dek

GSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPsAKPNDGFLLQLLEYEGKLYN
|..|||. . |..||.....| |||. |..||. ....... | . ||.|.| ||.|.| .|..
ggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

subfamily_DSP1_pd Subfamily DSP1 76-228 1e-28 94.4 In-house 12-157 (163) alignment
Range on Protein: 76-228
Range on HMM: 12-157/163.0
TSFYEMVDasEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYF
...|. |   .|  .| .| . .  |.|.|....|  .||.|..   | .|  |||..||||  ..|.  |... ..|....|||     . .||..   
lklydPve..kildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkk.....nGkvlihCqa

GLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.|||...|.|.|||.. ..||. ..  | . .  .|| || ||||.|| || 
GisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

0037934 (Phosphotyrosine protein) phosphatases II 77-227 6.1e-18 60.7 In-house 32-241 (243) alignment
Range on Protein: 77-227
Range on HMM: 32-241/243.0
SFYEMVDASEINTYLLIGNQPSVE--------NTEFLSRKRILFVLNLSNSP---------------------------------------------VPV
| |   . ...  .| ....|  |        . ..| . .|  ...| .                                                ..
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

TRDGIEYKSVKLED----DDEEDLLGVLQDCLDFLHKAKKKCESNKGSRVLVYSYFGLSRSASVCVAHLMKEE-GWTLEKSWNHLKAQHPS-AKPNDGFL
|| .| |  .   |    |. ||||  |... .|....      ..|..|||  . |..|.. ...| ||..  |..||. ...|..| |  | .. ...
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

LQLLEYEGKL
 .| |.. .|
rflyeallel

0049772 (Phosphotyrosine protein) phosphatases II 78-228 6.1e-27 90.6 In-house 100-274 (314) alignment
Range on Protein: 78-228
Range on HMM: 100-274/314.0
F----------YEMVDASEINTYLLIG-----------------------------NQPSVENTEFLSrkrilfvlNLSNSPVPVTRDGIEYKSVKLEDd
|          ..||  ...|.  . .                             |.|.... |.|         .  ..|  ..| ||.|. . ..| 
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk........eelydpelferlgikylripvpD.

DEEDLLGVLQDCLDFLHKAkkkcesNKGSRVLVYSYFGLSRSAS-VCVAHLMKEEGWTLEKSWNHLKAQHPsAKPNDGFLLQLLEYEGKLY
....||  ....|.|...|      .||..|||    | .|... |..| |||  |..||. ........| ..||.||. ||..|| .|.
gsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefile

0045098 (Phosphotyrosine protein) phosphatases II 78-229 2e-17 59.0 In-house 16-273 (278) alignment
Range on Protein: 78-229
Range on HMM: 16-273/278.0
FYEMVDASEINTYLLIGNQP-----------------------------------------SVENTEFLSRKRILFVLNLSNS-----------------
.. . . |||...|..||..                                            . ..|   .|  ...| .                  
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

---------------------------------PVPVTRDGIEYKSVKLEDDDEEDLL--GVLQDCLDFLHKAKKKCESN---------KGSRVLVYSYF
                                 .   .|    .. .  .| .  .|     ....|.|...| |.  |          .| .|||  . 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GLSRSASVCVAHLMKEE---GWTLEKSWNHLKAQHPS-AKPNDGFLLQLLEYEGKLYN
|..|.. ...|.||.|    |..|..  ..|. | |  | .| ... .| |.. .|..
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_DSP10_pd Subfamily DSP10 79-230 3.6e-28 92.4 In-house 9-156 (159) alignment
Range on Protein: 79-230
Range on HMM: 9-156/159.0
YEMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN-SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGL
.| ..||.. ..|..|..   .... | | .| .|||. . .|   . ....|| ....|  ...|    .. |.|...|.||     ||||||.   |.
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkk.....gsrvLvhCqaGi

SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
||||.| .|.|||. . .|...... | . |   || .|. ||||.| .| . 
srsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks

subfamily_Slingshot_pd Subfamily Slingshot 80-231 4.7e-29 94.9 In-house 15-161 (169) alignment
Range on Protein: 80-231
Range on HMM: 15-161/169.0
EMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSR
 . .||.|  .. .| .    | | |..... ..||...       . .||. ... |..|.|||   ..  .|..||||     |||.|||.   |.||
qldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakk.....kgskvlvhckmGvsr

SASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGK
|||. .|. ||| |..||......| .   .|||.||| || |||| |   |
sastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileask

0046846 (Phosphotyrosine protein) phosphatases II 80-228 6.6e-19 63.8 In-house 8-173 (176) alignment
Range on Protein: 80-228
Range on HMM: 8-173/176.0
EMVDASEINTYLLIGNQP----------SVENTEFLSRKRILFVLNLSNS-----------PVPVTRDGIEYKSVKLEDDDEEDLlGVLQDCLDFLHKAK
.  | ..|| .|..|. |            .. |.| . .|  |.|| .            .  ... ||.|. .  .| .  ||   |...|.|...| 
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

KKcesnkGSRVLVYSYFGLSRSASVCVAHLMKE-EGWTLEKSWNHLKAQHP-SAKPNDGFLLQLLEYEGKLY
|.     | .|||  . |..|.. ...| |..   |...|.   ....|.|  | ...... .| |.| .|.
ke.....ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_DSP3_pd Subfamily DSP3 80-229 7.7e-19 61.9 In-house 7-159 (162) alignment
Range on Protein: 80-229
Range on HMM: 7-159/162.0
EMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPV-PV-------TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnKGSRVLV
.. .. |.   | .|.. . .. . | .  |  ||| ... .  |       .  .|.|  ....|  | ||    .   .|...| ..    | ..|||
lskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq....kegkvlv

YSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHpSAKPNDGFLLQLLEYEGKLYN
 .  |.|||| . .|.||  .  || .  .. ...  .  ||.||| || |.. .| .
hcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkr

0036282 (Phosphotyrosine protein) phosphatases II 81-227 5.4e-19 64.0 In-house 9-169 (174) alignment
Range on Protein: 81-227
Range on HMM: 9-169/174.0
MVDASEINTYLLIGNQPSVeNTEFLSRKRILFVLNLSNSPVPV---------------TRDGIEYKSVKLEDDDEEDLLGvLQDCLDFLHKAKKKcesNK
 .| |.|...|..|. |   . |.| . .|  |..| ..  .                .| ||.|. .  .|. . ||   |.....|...| ..   ..
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse...dp

GSRVLVYSYFGLSRSASVCVAHLMKEEGW-TLEKSWNHLKAQH---PSAKPNDGFLLQLLEYEGKL
|  |||    |..|.. ...| ||.  .. .|.. ........   | . ...... .| ..| .|
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

0042113 (Phosphotyrosine protein) phosphatases II 81-226 6.5e-19 63.8 In-house 44-241 (245) alignment
Range on Protein: 81-226
Range on HMM: 44-241/245.0
MVDASEINTYLLIGNQPSVENTE----FLSRKRILFVLNLSNS----------------------------------------------PVPVTRDGIEY
.|| ..|.  ......|. |..|    .| . .|  ...|..                                               . . .| .| |
yvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihy

KSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
  .  .|... |||  |.|.|.|..|| ..   ... .||| .  |..|.. ...| ||     || |..||.   .|. | | | ...... .| |.. 
hylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

K
.
e

0051082 (Phosphotyrosine protein) phosphatases II 81-223 3.2e-18 61.2 In-house 5-149 (151) alignment
Range on Protein: 81-223
Range on HMM: 5-149/151.0
MVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN------SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesNKGSRVLVYSY
. ..| .  .|.....|. .. |.| .  |  ..|| .       | .... |||.. . ..|... .|   .. .|.||... .    .|.  |||.  
yinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld....kkngpvlvHCs

FGLSRSASVCVAHLMKeEGWTLEKSWNHLKAQHP-SAKPNDGFLLQLLEY
 |..|.. .... ||. .|..||. ........| .  ||..||.||...
aGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_DSP19_pd Subfamily DSP19 82-226 7.2e-31 101.6 In-house 10-149 (152) alignment
Range on Protein: 82-226
Range on HMM: 10-149/152.0
VDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCesnkgSRVLVYSYFGLSRSA
....|.. .|..| | .....| |..|.|  .||..   . |  . ..|.|... |..|.||| .|...|||...|..|       .|||    | ||||
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskd.....gavlvHCnAGvSRsa

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGK
|| .|.|||.|  .||.. . .....|..|||.||. || ||| .
svviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae

subfamily_DSP14_pd Subfamily DSP14 82-237 4.9e-29 95.3 In-house 5-153 (157) alignment
Range on Protein: 82-237
Range on HMM: 5-153/157.0
VDASEINTYLLIGnQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSA
   |.|. .| ..   .. . | |..|.|  ..|..   .  . ..||.  |..||. |..|   ..   | ....||     || ..||. . | ||||
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkk.....kggktlvhCvaGvSRSA

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGKiSMRMQ
|.|.|.||| |  .|.......|.. |  .|| ||  || .|| ||.. . |..| 
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks.svkmv

subfamily_DSP8_pd Subfamily DSP8 82-228 3.1e-25 82.6 In-house 13-155 (159) alignment
Range on Protein: 82-228
Range on HMM: 13-155/159.0
VDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRS
|.  .|  .| .| |  | . |.||.. | .|||.||| | . .    ..  | ..|. .|.|| ...  ..|. |||..      .||||. . | |||
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkakse.....ngrvlvhvlaGisrs

ASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.| .|..||.   .|.......| . |. .||  || |||||| .| 
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

0041856 (Phosphotyrosine protein) phosphatases II 83-230 2.5e-24 81.3 In-house 18-175 (182) alignment
Range on Protein: 83-230
Range on HMM: 18-175/182.0
DASEINTYLLIGNQPS--------------VENTEFLSRKRILFVLNLSNSPV---PVTRDGIEYKSVKLEDDDEEDllgvLQDCLDFLHKAKKkcesnK
| ..|| .|..|..|.               .. ..| . .|  ..||.. .     ..| ||.|. .  .|..  |    |...|||......     .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.....e

GSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHP--SAKPNDGFLLQLLEYEGKLYNG
| .|||    |..|......| |||. |..||. ..... . |     || .|.|||...| .|.. 
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_DSP12_pd Subfamily DSP12 84-225 1.7e-29 97.2 In-house 2-141 (155) alignment
Range on Protein: 84-225
Range on HMM: 2-141/155.0
ASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPV---TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRS
.|.|.. |..|. . |...|.|.   |  || . . ..|    ..  ...|.... |..|||.|  |....||...| ..     .  |||  ..|.|||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealee.....egavlvHCqagvSRS

ASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
.....|.|||.|.. |||  . .|...|...||.||| ||  .| 
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfek

PTPc_motif_SM00404 84-225 1.9e-28 94.1 In-house 2-139 (140) alignment
Range on Protein: 84-225
Range on HMM: 2-139/140.0
ASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSAS
 |.|  .| .|.... .| ..|. ..| .|.|.... ...    |.......|.|.....|.  |. .|||...|      .|| .|||. . |.||||.
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSat

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
...|.||......|..... .| . |. .|| .|. ||.||| 
liiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_LRR-DSP_pd Subfamily LRR-DSP 84-230 3.3e-15 49.9 In-house 120-261 (263) alignment
Range on Protein: 84-230
Range on HMM: 120-261/263.0
ASEINTYLLIGNQPSVENTEFLSRKRILFV-LNLSNSpVPVTRDGIEYKSV-KLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGsRVLVYSYFGLSRSA
 .||   | .| . |  |  .|  . .  . | ...   |.  .   | |. ..|| || |.   ...   |... .||     |  |||.   |.|||.
PdeiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkk.....G.GvlvhcraGvsrss

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
.. ...||| .  ..... .  . . |  .|| ||. ||. || ||.  
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct

0048076 (Phosphotyrosine protein) phosphatases II 85-228 1.1e-28 95.1 In-house 5-143 (145) alignment
Range on Protein: 85-228
Range on HMM: 5-143/145.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSASVC
|||  .| .|..|.... |.| .  |  ||||.. .  ..| ||.|  . ..| .. |||  |...|.|...| |.     | .|||. . |..|.....
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlv

VAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
.|.||...|..||. ......|.| | ||.|.| .|.|.| .|.
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell

0048179 (Phosphotyrosine protein) phosphatases II 85-227 4.3e-27 90.0 In-house 5-144 (144) alignment
Range on Protein: 85-227
Range on HMM: 5-144/144.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS--PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSAS
|||  .| .|..|.... |.| .  |  |.||...  |  ..| ||.|  . ..| .  |||  |...|.|...| .     .| .|||. . |..|...
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgt

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
...|.|||..|..||. ........| | ||.|.| .||||| .|
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

subfamily_DSP6_pd Subfamily DSP6 85-227 4.2e-25 82.1 In-house 15-154 (158) alignment
Range on Protein: 85-227
Range on HMM: 15-154/158.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDG-IEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSAS
 || ..| .|.. . .|.| |.. .| .|||. .  |     .| ..|. . .||  ...|   . . ..|. .|..|      | |||. . |.|||  
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.....kskvlvhClaGisrsvt

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
|..|.|||..  .|..... .|.....  ||  |. |||..| .|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_DSP15_pd Subfamily DSP15 85-225 3.3e-24 79.7 In-house 3-137 (151) alignment
Range on Protein: 85-225
Range on HMM: 3-137/151.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDgIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSASVC
|.. . | .||    ...| |..|.|  .|...... .. .| |||| ....|  . .| ...... .|.||.. |     .  |||.   |.|||. ..
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlk.....eenvlvhClaGvsRsvtlv

VAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
||.||       ... . .||.  .|.|| ||  || ||| 
vaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 85-224 9.8e-21 67.8 In-house 8-144 (148) alignment
Range on Protein: 85-224
Range on HMM: 8-144/148.0
SEI-NTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSAS
||| ...| .|...|  . | |    .  . | ... . ..   ||||  |.|.|...|||  . .|  .|..|||     ..| ||||    | |||. 
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkak.....deGrrvLvhlqmGvsrssa

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
. ...|.. .  .|..  .  | . .  .|| ||| || |.|
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 87-227 4e-17 56.0 In-house 6-152 (154) alignment
Range on Protein: 87-227
Range on HMM: 6-152/154.0
INTYLLIGNQPSVENTEFLSRKRILFVLNL-SNSPVPVTR------DG--IEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCESNKgsrVLVYSYFGL
  ..| |. . .  |   |  |.|  .||    ..   |       ||  |||  ..| || . |..  |. ...|...|    | ||   |||.|  |.
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennk...vlvhsdkGv

SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
||||.. ...||..   .| ..   ||   .  ||| ||| ||  .| .|
srsaallisylmdklkislslalellkdsryiikPnqGflkqleifekel

subfamily_MKPLT_pd Subfamily MKPLT 88-225 9.7e-23 74.5 In-house 26-158 (164) alignment
Range on Protein: 88-225
Range on HMM: 26-158/164.0
NTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAH
.  |  ||   ..| . |    |  ..|.|.         .||  ||.||  .| |   |.   .|| .|      . | ||||.   | |||.|| || 
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.....idsGGrvlvhcvqGksrsssvtvaf

LMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
|.| .||||......|| .   ..|| ||| || ..| 
LikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 88-225 9.7e-23 74.5 In-house 26-158 (164) alignment
Range on Protein: 88-225
Range on HMM: 26-158/164.0
NTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAH
.  |  ||   ..| . |    |  ..|.|.         .||  ||.||  .| |   |.   .|| .|      . | ||||.   | |||.|| || 
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.....idsGGrvlvhcvqGksrsssvtvaf

LMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
|.| .||||......|| .   ..|| ||| || ..| 
LikskgwtlkeayeylkerrsivapnrGflkqlakfee

0043147 (Phosphotyrosine protein) phosphatases II 89-228 4.3e-21 70.8 In-house 24-161 (172) alignment
Range on Protein: 89-228
Range on HMM: 24-161/172.0
TYLLIGNQPSVENTEFLSRKRILFVLNLSNS---PVPVTRDGIEYKSVKLEDDDEEdLLGVLQDCLDFLHKAKkkcESNKGSRVLVYSYFGLSRSASVCV
 ..  .. .  .. ..| .. |  ..|| .    | ...| ||.|  .  .| .   || .|...|.|....      ..| .|||  . |..|.. ...
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidell...alspggpvlVHCsaGvgRtgtlva

AHLMKeEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.||. .|..||.  ...... | | .|.... .|...| .|.
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll

0051429 (Phosphotyrosine protein) phosphatases II 89-235 1.1e-13 47.0 In-house 22-232 (272) alignment
Range on Protein: 89-235
Range on HMM: 22-232/272.0
TYLLIGNQP---SVENTEFLSRKRILFVLNLSNSP------VPVTRDGIEYKSVKLEDDDEEDLLGVL--------------------------------
 .|. ...|   .... ..| . .|  ...| .        ..    ||.|  . ..||.... |                                   
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QDCLDFLHKAKKkcesnkGSRVLVYSYFGLSRSASVCVAHLMKeEGWT--------------LEKSWNHLKAQHPSAKPNDGFL
                . .|..|.   .      | .|||  . | .|.. |... |.  .|..              ||. ...|.|| | | ......
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

LQLLEYEGKLYNGKISMR
|.|.|.. .|... .|.|
lflyeallellrsllsvr

0049260 (Phosphotyrosine protein) phosphatases II 91-227 3.5e-17 57.9 In-house 15-149 (152) alignment
Range on Protein: 91-227
Range on HMM: 15-149/152.0
LLIGNQPSVENTEFLSRKRILFVLNLSNSP---VPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkcESNKGSRVLVYSYFGLSRSASVCVAH
. .|...  .. ..| .  |  ...| .      . .  .|.|. .  .|.   ||  .|...|.|..|.      .|| .|||  . |..|.. ...| 
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaay

LMKeEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
||.  |..||.  ...... | | || |.| .|.|.|..|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

DSPc Dual specificity phosphatase, catalytic domain 93-224 7e-26 85.7 Pfam-A 3-131 (133) alignment
Range on Protein: 93-224
Range on HMM: 3-131/133.0
IGNQPSVEnTEFLSRKRILFVLNLSNSPVP---VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAHLM
.|.... .  ..|. . | .|.|....       .   ||| ....||..|...   |... .|..||      .|| .|||. . |.||||....|.||
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlm

KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
|.....|.. ....| . ..  ||.||| ||||||
ktknlslneAyefvkerrskispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 93-224 7e-26 85.7 In-house 3-131 (133) alignment
Range on Protein: 93-224
Range on HMM: 3-131/133.0
IGNQPSVEnTEFLSRKRILFVLNLSNSPVP---VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAHLM
.|.... .  ..|. . | .|.|....       .   ||| ....||..|...   |... .|..||      .|| .|||. . |.||||....|.||
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlm

KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
|.....|.. ....| . ..  ||.||| ||||||
ktknlslneAyefvkerrskispnagflrqLleye

0040439 (Phosphotyrosine protein) phosphatases II 103-228 1.8e-17 59.2 In-house 72-246 (249) alignment
Range on Protein: 103-228
Range on HMM: 72-246/249.0
EFLSRKRILFVLNLSNSPVP-------------------------------------------VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKK
..| . .|  ...|..   .                                            . . .... .   |  . ..   ..|.|||.....|
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

KCESN-KGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
 .|.. ||..||| .  |..|.. ...| ||     || |..||  ...|. | | | .|.... .|.|.. .|.
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0045450 (Phosphotyrosine protein) phosphatases II 105-229 1.1e-16 56.9 In-house 127-305 (307) alignment
Range on Protein: 105-229
Range on HMM: 127-305/307.0
LSRKRILFVLNLSNSP-------------------------------VpvtRDGIEYKSVKLEDD-----------------DEEDLLGVLQDCLDFLHK
| ....  ...|...                                .    ||. .  ....|                   . ..   ....|||...
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

AKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLMKEEG--------WTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYN
..| .|.. ||..||| .  |..|......| ||.. .        ..|.. ...|..| | | .| ... .| |.. .|..
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

0038934 (Phosphotyrosine protein) phosphatases II 105-230 1.5e-12 43.0 In-house 52-179 (194) alignment
Range on Protein: 105-230
Range on HMM: 52-179/194.0
LSRKRILFVLNLSNS-----PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKS
|  ...  |..|.|.     |  ... |||| .   .|| .   | .|.. ||....  ..   ..|  |.|  . ||.|.. ...|.|..  |...|..
llnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne...dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

WNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
 ....   |.| || ..| .||.. . |...
ialfrekRpgaipnqdyleallkrykelrka

0043336 (Phosphotyrosine protein) phosphatases II 109-224 6.9e-13 44.1 In-house 157-273 (278) alignment
Range on Protein: 109-224
Range on HMM: 157-273/278.0
RILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDllgVLQDCLDFLHKAKKKCEsNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHL
 ....|...|   . .| .  |  ..  |..  .    |.. ||||.......| .... ||| .  |..|.. .... |.     || |..||. ...|
ytvrtlevtnlgdgesrtvthyhylgwpdhgvpe...slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

KAQHPSAKPNDGFLLQLLEYE
. | |.| ... .. .| |..
reqRpgavqtpsqyrflyeal

0040438 (Phosphotyrosine protein) phosphatases II 112-228 2.9e-16 55.1 In-house 113-276 (317) alignment
Range on Protein: 112-228
Range on HMM: 113-276/317.0
FVLNLSNSPVP---------------------------VTRDGIEYKSVKLEDD----------------DEEDLLGVLQDCLDFLHKAKKKCEsNKGSR
 ...| ..  .                           .. .||..  ...||.                .. ..   ....||||.......| ..|. 
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

VLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
||| .  |..|......| ||     ||.|...|. ...|..| | | .. ... .| ... ...
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0039614 (Phosphotyrosine protein) phosphatases II 112-230 1e-14 50.2 In-house 128-291 (297) alignment
Range on Protein: 112-230
Range on HMM: 128-291/297.0
FVLNLSNSPVP-------------------------VTRDGIE-----------------YKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCesNKGSRV
 ...| .                              ..||.                  .  ..  |..  ..| .|.. |.....| ...  .|| .|
vivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael..pkggpv

LVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
|| .  |..|......| ||     || |..... ...|. | | | ...... .| ... .|.. 
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

subfamily_PTPMT1_pd Subfamily PTPMT1 124-224 5.8e-08 27.4 In-house 70-165 (171) alignment
Range on Protein: 124-224
Range on HMM: 70-165/171.0
TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEY
.. |.|. ...  |  |.  |  |.. ..|..| .     .||.|| |    | .|||..  ..|||.| ...|. ...||.. .  . ..  . .| ||
kklgveqlqlatvDfteapdleklekgvefiekva.....skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey

E
|
e

subfamily_STYXL1_pd Subfamily STYXL1 127-228 2.6e-18 59.7 In-house 58-154 (157) alignment
Range on Protein: 127-228
Range on HMM: 58-154/157.0
GIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGK
  .   ...||..| |||  |..  .|..| ||     .|. |||.|  |.||||.| .|.|| .. .||.|....||  ..  ||| .|. || |.| .
vakllhiavedeneadllerlkeavqfiekhkk.....egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq

LY
|.
ll

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 132-228 8.5e-10 31.9 In-house 51-142 (145) alignment
Range on Protein: 132-228
Range on HMM: 51-142/145.0
SVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
 .  || .  ||   ...  ||. | |     ..|. |.|.   |.||| .| || |||  . || ..   ....   | ||  || .||. | .| 
litaedlesydlsqhfdevtdfidkgk.....eegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk

0036941 (Phosphotyrosine protein) phosphatases II 142-231 5.6e-14 47.6 In-house 182-280 (297) alignment
Range on Protein: 142-231
Range on HMM: 182-280/297.0
DLLGVLQDCLDFLHKAKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLM--------KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGK
..    ...|||.....|...   .|..||| .  |..||.....| ||        ||.|... . ...|. | | | .. .....| |.. .|.. |
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0051299 (Phosphotyrosine protein) phosphatases II 146-214 5.6e-08 28.1 In-house 200-272 (288) alignment
Range on Protein: 146-214
Range on HMM: 200-272/288.0
VLQDCLDFLHKAKKKCEsNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPND
 ....||||....|... ..|. |.| .  |..|.. .... |.     ||.|..... ...|. | | . .. 
spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0047943 (Phosphotyrosine protein) phosphatases II 147-221 9.9e-10 33.8 In-house 185-265 (273) alignment
Range on Protein: 147-221
Range on HMM: 185-265/273.0
LQDCLDFLHKAKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLL
|...|.|.....|..|.. ... |.| .  |..|........|.     || |..... ...|. | | . ..  ....| 
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly

0050432 (Phosphotyrosine protein) phosphatases II 147-213 8.8e-08 27.3 In-house 216-284 (308) alignment
Range on Protein: 147-213
Range on HMM: 216-284/308.0
LQDCLDFLHKAKKKCesnKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPN
....||||....|..   .|. ..| .  |..|.. .... |.     || |..... ...|. | | . ..
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt

0046845 (Phosphotyrosine protein) phosphatases II 148-211 4.1e-07 25.1 In-house 185-257 (284) alignment
Range on Protein: 148-211
Range on HMM: 185-257/284.0
QDCLDFLHKAKKKCES-NKGSRVLVYSYFGLSRSASVCVAHLMKEE--------GWTLEKSWNHLKAQHPSAK
.| |.||..... .|. ..|. ..| .  |..|.. .....|..|         |..... ...|. | | . 
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv

0048567 (Phosphotyrosine protein) phosphatases II 151-212 5.3e-07 24.1 In-house 57-123 (157) alignment
Range on Protein: 151-212
Range on HMM: 57-123/157.0
LDFLHKAKKKCE--SNKGSRVLVYSYFGL---SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKP
 .| .|..|...  ...| .. |....||   .|.| .. ..|..  |.| |. ...|.  .|. .|
yrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp

subfamily_MSG5_pd Subfamily MSG5 163-227 7.8e-13 41.9 In-house 96-160 (165) alignment
Range on Protein: 163-227
Range on HMM: 96-160/165.0
SNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
  |. ..||.   |||||||. ||..||  . .|......||..    .|. |...||.|.|  |
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

subfamily_STYX_pd Subfamily STYX 163-236 1e-10 35.0 In-house 93-165 (166) alignment
Range on Protein: 163-236
Range on HMM: 93-165/166.0
SNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGkLYNGKISMRM
 .|| .|||.   |.||||.. .|..|.  |    ... ... .    .||.||  || |||  .|  |.....
lqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea.iylakltikl