Gene DSP10 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP005_AA protein Get Run
AqueP005_AA_172-318 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 15-131 6.5e-14 44.4 Pfam-A 2-110 (113) alignment
Range on Protein: 15-131
Range on HMM: 2-110/113.0
PHQLARNLhSREDYVLLDCRPVLAYNNCHISGAVNVNFTGLMKKRFIAGKIGLADLVTTEEGRERFRKSVssptVVYDedtkDVKLLGSSTSISLVLAAL
. .|...|   |..||||.|.  .|.  || |||||..  |...|    |  ||. . . . .    | |    |||.      .  .. .  .|. . |
akelkell.ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktv....vvyc....rsgnrsggaaalllalil

TTMGR-NMFVLQGGLNAF
  .|  |..|| ||..|.
kelgyknvyvLdGGfeaw

0045098 (Phosphotyrosine protein) phosphatases II 157-316 8.3e-27 89.7 In-house 4-273 (278) alignment
Range on Protein: 157-316
Range on HMM: 4-273/278.0
RASTPGMRDQALDWHTAPPVNVLSFLVLGSEK-----------------------------------------DARSKLVFDWFNITYVLNVTPTC----
.||.. . .    ... .|  .. .| ||. .                                          |     .   .||.....|.      
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

--------------------------------------------PNNFEGAGVVYKRI-PVSDTGTQKLS--NKFTEAFEYIEEIRK-------------
                                            ....| .|| .  . |. | |.  |.  . | |..|.|.| .|             
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

-KNGVVLIHCMAGISRSVTLTIAYLMAHF---GMSMQDAYQFVKDKRPA-ISPNLNFMGQLVEFERELQK
 ..|.||.||.||..|. || .|||| .    |.....|..... .||  . .||... .| ||..|| .
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_DSP10_pd Subfamily DSP10 163-319 1.6e-78 256.1 In-house 2-158 (159) alignment
Range on Protein: 163-319
Range on HMM: 2-158/159.0
MRDQALDWHTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMA
..... |..||| ..||.||.|||||||... ..|..|||.|||||...||.||.... |||||||||..|.|...|.||.|.|||.|||.  ||.||.|
lspteadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqa

GISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNPS
|||||.|..|||||.|...|..|||.|||.|||.|||||||||||.|||.||.|. .
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska

subfamily_LRR-DSP_pd Subfamily LRR-DSP 166-316 7.1e-28 91.4 In-house 111-260 (263) alignment
Range on Protein: 166-316
Range on HMM: 111-260/263.0
QALDWHTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRI-PVSDTGTQKLSNKFTEAFEYIEEIRKKNGvVLIHCMAGI
. . . .. | ...  | ||. . |  | ..   ..|..|     .   |      |  |  . |.   ..|. | |   .||| ||| | ||.|| ||.
slitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfP.klfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGv

SRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
||| ||.|.||| .  . ...|. .|. ||| | ||  |. ||  .|..| .
srsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc

subfamily_STYXL1_pd Subfamily STYXL1 167-315 6.1e-25 81.3 In-house 3-154 (157) alignment
Range on Protein: 167-315
Range on HMM: 3-154/157.0
ALDWHTAPPVNVL-SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVV--YKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAG
 ||  .  ||.|| ..| || .|.| .. .   . .  ..||.  . . ..|   |    .|.|.|.   .| ... || ..||. .|.. |||.    |
eldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkG

ISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
||||... ||||| .  .....||...|. .. . || .|. || |.|..| 
isrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll

0041856 (Phosphotyrosine protein) phosphatases II 168-318 1.4e-33 111.4 In-house 12-176 (182) alignment
Range on Protein: 168-318
Range on HMM: 12-176/182.0
LDWHTAPPVNVLSFLVLGSEKD--------------ARSKLVFDWFNITYVLNVTPTC--PNNFEGAGVVYKRIPVSDTGTQKlsnkFTEAFEYIEEIRK
  .|. ..  ..  |.||| ..              |.    .   .||...|.|. .  |...| .|. |...|. | |.      . |....|||...
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

KNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRP--AISPNLNFMGQLVEFERELQKNP
..|.||.||.||..|. || .|||| . |.|...|...|. .||   |.|| .|. ||...|. |.|. 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

0037934 (Phosphotyrosine protein) phosphatases II 168-314 2.9e-27 91.2 In-house 32-241 (243) alignment
Range on Protein: 168-314
Range on HMM: 32-241/243.0
LDWHTAPPVNVLSFLVLGSE--------KDARSKLVFDWFNITYVLNVTPTC--------------------------------------------PNNF
 |.  |  ..|.  | ...         ..|     .   .||.....|...                                            ....
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

EGAGVVYKRIPVSD----TGTQKLSNKFTEAFEYIEE-----IRKKNGVVLIHCMAGISRSVTLTIAYLMAHF-GMSMQDAYQFVKDKRPA-ISPNLNFM
.  .. | ..|. |    . .. | . . |. |.|||      ....|.||.||.||..|. || .|||| .  |.....|.......||  . ......
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

GQLVEFEREL
 .| |...||
rflyeallel

subfamily_DSP6_pd Subfamily DSP6 171-317 8e-55 178.7 In-house 10-157 (158) alignment
Range on Protein: 171-317
Range on HMM: 10-157/158.0
HTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAG-VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVT
... ||..|..| |||.|||    |.. ..| ||||||.  || || .| . |..||..|  .|.|.. | ||.|.|.| |.|.  ||.||.||||||||
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
.|.|||| .  .|..|||..||.... ||||.||||||..|||.|. .
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls

subfamily_DSP8_pd Subfamily DSP8 171-316 8.9e-46 149.3 In-house 11-156 (159) alignment
Range on Protein: 171-316
Range on HMM: 11-156/159.0
HTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTL
..  | ..| .| |||.||. |. ...  .|.||||.  .||.  |   . . |.|| |. . ||.. | ...|.|. ....|| ||.|..|||||| |.
advgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatv

TIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
 |||.| .. ||...||.|||.|||.|||||||.|||.|.|.||..
aiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl

0044763 (Phosphotyrosine protein) phosphatases II 173-318 1.7e-39 130.6 In-house 21-174 (178) alignment
Range on Protein: 173-318
Range on HMM: 21-174/178.0
APPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT--------CPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIR-KKNGVVLIHCMAG
 ... .| .| |||  .|. .  .   .||...|.|..        .|  .|.||. |..||..| |.. |.  | |..|.|||.. .|.|.||.||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPaISPNLNFMGQLVEFERELQKNP
..|| || .|||| ..|.|...|...|. .|| |.|| ... || |||..|.|..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes

PTEN_1 173-317 2.9e-32 107.1 In-house 35-194 (196) alignment
Range on Protein: 173-317
Range on HMM: 35-194/196.0
AP-----PvNVLSFLVLGSEKDARSKL-VFDWFNITYVLNVTPTCPN--------NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--KNGVV
||        .  .| .||.||... |  ..  .|| |.|... ...         |.  || |...|. | |.. ||  | .. . || ...  ...||
apsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvV

LIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
|.|| ||..||.|. .||||.. ......| ..|..|||...||  .. .|.|...||...
lVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae

subfamily_DSP1_pd Subfamily DSP1 174-316 3.1e-45 148.2 In-house 16-158 (163) alignment
Range on Protein: 174-316
Range on HMM: 16-158/163.0
PPVN-VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGaGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTI
 ||. .| || ||||..|  . . .  .|| .|||. ...| ||     ||.....|. .. .|  |.|. |.|.|..|||| ||||| |||||| || .
dPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
|||| .  .|...|..|||..|. ||||..|..||...|..|..
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll

subfamily_Slingshot_pd Subfamily Slingshot 174-314 9.7e-33 106.9 In-house 18-157 (169) alignment
Range on Protein: 174-314
Range on HMM: 18-157/169.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAgVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
 . ..  .. |||| .|     ..  ...|.||||  . | |..  . |..| | |. ...| ... |....||. .||.  ||.||  |.||| .  ||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpek.feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
| | ..|.|...|...||..|  | || .|. || |.|  |
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

subfamily_MKPLT_pd Subfamily MKPLT 174-312 4.4e-27 88.6 In-house 21-158 (164) alignment
Range on Protein: 174-312
Range on HMM: 21-158/164.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
| | .   | ||  |.|... | .  .||...||.  . ..|    |.| .. |.|. ...||. .  | ... .  .  | ||.||  | ||| . |.|
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|.   |  ...||...|..|  ..||  |. || .||.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 174-312 4.4e-27 88.6 In-house 21-158 (164) alignment
Range on Protein: 174-312
Range on HMM: 21-158/164.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
| | .   | ||  |.|... | .  .||...||.  . ..|    |.| .. |.|. ...||. .  | ... .  .  | ||.||  | ||| . |.|
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|.   |  ...||...|..|  ..||  |. || .||.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee

PTPc_motif_SM00404 175-312 5.1e-43 141.3 In-house 2-139 (140) alignment
Range on Protein: 175-312
Range on HMM: 2-139/140.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAY
| ..|  | |||...| .. . . ..||.|.||| ..... |  |. ...||..|....|||... .. ..||...||.| ||.||.||.|||.||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
||   ..|...||.|||..||.|||||||. ||.|.|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0048076 (Phosphotyrosine protein) phosphatases II 175-315 6.8e-35 115.2 In-house 4-143 (145) alignment
Range on Protein: 175-315
Range on HMM: 4-143/145.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPnNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAY
|  .|  | |||  .|..   .  ..||.|||.|.... ..|  |. | ..|. | |.. |.. . |..|.|||..|..|.||.||.||..|. || .||
pseilpglylgslptaldlellkdlgittvlnltsele.llerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
|| ..|.|...|...|. .|| . || ... .| |||.||.
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelell

0048179 (Phosphotyrosine protein) phosphatases II 175-313 1.6e-34 114.0 In-house 4-143 (144) alignment
Range on Protein: 175-313
Range on HMM: 4-143/144.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGA-GVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
|. .|. | |||  .|..   .  ..||.|.|.|......|..  |. | ..|. | |.  |.. . |..|.|||.....|.||.||.||..|. || .|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERE
||| ..|.|...|...|. .|| . || ... .| |.|..
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0043147 (Phosphotyrosine protein) phosphatases II 175-314 3.2e-34 113.5 In-house 19-160 (172) alignment
Range on Protein: 175-314
Range on HMM: 19-160/172.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT--CPNNFEGAGVVYKRIPVSDTGTQkLSNKFTEAFEYIEE--IRKKNGVVLIHCMAGISRSVTL
| ... .. .... .|     .   .||...|.|.    | ..|  |. | ..|. | |.. |.. . |..|.|.|  .....|.||.||.||..|..||
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

TIAYLMAhFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
 .||||   |.|...|...|..||| ...| ... .| .||. |
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

subfamily_DSP19_pd Subfamily DSP19 177-315 9.2e-37 120.7 In-house 14-151 (152) alignment
Range on Protein: 177-315
Range on HMM: 14-151/152.0
NVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLM
.|   | |||   | .|  ..  .||..|||.   || |    . |. |.. |.  ..|.. . ||...||| |.|.|.||.|| ||.|||... |||||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp.kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
..  .|...|.. |...||.|.||  |. || |.| ||.
kkeelsleealelvrearpcikPneGFikqLkeyeaell

subfamily_DSP14_pd Subfamily DSP14 178-319 5.3e-38 124.4 In-house 10-149 (157) alignment
Range on Protein: 178-319
Range on HMM: 10-149/157.0
VLSFLVLGsEKDARSKLVFDWFNITYVLNVTPTCPNnFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMA
. . | |.    |.|| ...  .|| ..|||.  ||  .  .. . ..||.|. ..||.. | |. ..|||..||.| .|.||.||.||| .|..|||| 
itpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmk

HFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNPS
.  .|...||. ||..|| |.||. |  ||...|..|... |
yeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss

subfamily_DSP15_pd Subfamily DSP15 178-314 3.3e-32 105.6 In-house 5-139 (151) alignment
Range on Protein: 178-314
Range on HMM: 5-139/151.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGagVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMA
||  | ||  .|.. .   .  ||| .|.|     . ..   . || |..|||  .|||. | |. |.| . | |.. ||.||.||.||||||..||||.
vlpglylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

HFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
   .. .|| ...| .|    ||. |  || |.|.  
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektk

subfamily_DSP12_pd Subfamily DSP12 178-315 7.7e-32 104.8 In-house 5-144 (155) alignment
Range on Protein: 178-315
Range on HMM: 5-144/155.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT-CPNNFEGAGVVY-KRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
.|  | ||. ... ..   . ..|| || |. .  |.  . .| |. | |.. |. .. . . . ||...||| ....| ||.||.||.|||||. ||||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
| . ..|...|...||.|.| |.|| .|. ||  ||.   
mkkeklslekAlklvkekkpeiepNegFleQLklfekmgc

subfamily_DSP3_pd Subfamily DSP3 178-317 2.2e-29 96.2 In-house 14-160 (162) alignment
Range on Protein: 178-317
Range on HMM: 14-160/162.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTP-------TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEE-IRKKNGVVLIHCMAGISRSVT
|   | .| |. |. |  .  . ||.||| .        | .. ...... |  ..|.|. . .||. |..|...|.| . .|.| ||.||..|.||| |
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

LTIAYLMAHFGMSMQDAYQFVKDKRpAISPNLNFMGQLVEFERELQKN
| .|||| .  |....| . |..|| .| ||  |. ||.|...||...
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrk

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 178-315 2.6e-26 85.8 In-house 6-153 (154) alignment
Range on Protein: 178-315
Range on HMM: 6-153/154.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGA------G--VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIR--KKNGVVLIHCMAGISRS
. .|| ..| . |  || ..  ||. .|||    .| |         |  . | .. . |   ... .|.  |||.|..     .|. ||.|. .|.|||
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

VTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
 .| |.||| .  .|.  |....|| |. |.||  |. ||  ||.||.
aallisylmdklkislslalellkdsryiikPnqGflkqleifekell

0049260 (Phosphotyrosine protein) phosphatases II 180-314 2.6e-30 100.5 In-house 13-149 (152) alignment
Range on Protein: 180-314
Range on HMM: 13-149/152.0
SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNF--EGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEE-IRKKNGVVLIHCMAGISRSVTLTIAYLM
 .. .|..  |  .  .   .||.....|  .....  .  .  |...|. | |...||  . .... ||. ...|.|.||.||.||..|. || .||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

AhFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
  .|.|...|...|. ||| . || ... .| |||. |
l.lgvsleeavalvrekRpgavpnpgqlrflyefekll

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 180-312 5.9e-30 97.7 In-house 13-145 (148) alignment
Range on Protein: 180-312
Range on HMM: 13-145/148.0
SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHF
.|| ||| | | .  .   ...| . | |  ..| ..  |. |  ....|   . ||  | .. ..... ... . ||.|.  |.|||  |....|. . 
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

GMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
 .|...|...||.||. . ||| |. || |.|.
rvslkealalvkskrryvdpnlgfLkqLaeleq

DSPc Dual specificity phosphatase, catalytic domain 183-312 4.7e-40 131.5 Pfam-A 2-132 (133) alignment
Range on Protein: 183-312
Range on HMM: 2-132/133.0
VLGSEKDARsKLVFDWFNITYVLNVTPTCPN--NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFG
 |||...|  . . . ..||.|.||| ..||   ..     | |||| |. ..|.|... || |.||....|.. ||.||.|||||| ||.|||||  ..
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|...||.|||..|..|||| .|..||.|.||
lslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 183-312 4.7e-40 131.5 In-house 2-132 (133) alignment
Range on Protein: 183-312
Range on HMM: 2-132/133.0
VLGSEKDARsKLVFDWFNITYVLNVTPTCPN--NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFG
 |||...|  . . . ..||.|.||| ..||   ..     | |||| |. ..|.|... || |.||....|.. ||.||.|||||| ||.|||||  ..
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|...||.|||..|..|||| .|..||.|.||
lslneAyefvkerrskispnagflrqLleyer

0051082 (Phosphotyrosine protein) phosphatases II 189-310 5e-24 80.0 In-house 22-149 (151) alignment
Range on Protein: 189-310
Range on HMM: 22-149/151.0
DARSKLVFDWFNITYVLNVTP-----TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKK-NGVVLIHCMAGISRSVTLTIAYLMAhFGMS
 |.    .   .|....|...     .||. .. .|. ...||. |. ...|.  | .. |..|....| ||.||.||.||..|. || ..|||.  |.|
ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvs

MQDAYQFVKDKRP-AISPNLNFMGQLVEF
...|..... ||| .. ||  |. || ..
leealeeyrlkrpgvvqpnqqflfqlfal

0046846 (Phosphotyrosine protein) phosphatases II 194-317 2.4e-30 101.0 In-house 42-175 (176) alignment
Range on Protein: 194-317
Range on HMM: 42-175/176.0
LVFDWfNITYVLNVTPT----------CPNNFEGAGVVYKRIPVSDTGTQKLsNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAH-FGMS
..... .||.|.|.|             .. .|..|. |...|. | |.  | . . |..|.|.| .|..|.||.||.|||.|. || .|||. . .|.|
mlkel.gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekgls

MQDAYQFVKDKRP-AISPNLNFMGQLVEFERELQKN
...|...|...||  . .. ... .| |||..|.|.
veealalvreqRplgavqtpeQyrflyefellllkk

0036282 (Phosphotyrosine protein) phosphatases II 199-314 1.4e-28 95.1 In-house 35-169 (174) alignment
Range on Protein: 199-314
Range on HMM: 35-169/174.0
FNITYVLNVTPTCPNN--------------FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKK--NGVVLIHCMAGISRSVTLTIAYLMAHFGM-
..||.|..... ....              .|  |. |...|. | |.  ||  . |.....||....  .|.||.||.||..|. || .|||| . .. 
lgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglle

SMQDAYQFVKDKR---PAISPNLNFMGQLVEFEREL
|..||...|. .|   | . .. ... .| .||. |
slvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

0051429 (Phosphotyrosine protein) phosphatases II 199-314 8.1e-20 67.0 In-house 44-224 (272) alignment
Range on Protein: 199-314
Range on HMM: 44-224/272.0
FNITYVLNVTPTCPNNFEG-----AGVVYKRIPVSDTGTQKLS---------------------------------------------------NKFTEA
 .|..........  ....     .|. | ..|. |....  .                                                   . . |.
lgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallel

FEYIEEirkkNGVVLIHCMAGISRSVTLTIAYLMAhFGMS--------------MQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
.|.. .    .| ||.||.||..|. |.  ..|..  |.|              ...|.. ....||.. ..  .. .| |...||
lellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel

0045450 (Phosphotyrosine protein) phosphatases II 200-315 5.3e-26 87.5 In-house 131-304 (307) alignment
Range on Protein: 200-315
Range on HMM: 131-304/307.0
NITYVLNVTPTCPNNF---------------------------EGAGVVYKRIPVSDT-----------------GTQKLSNKFTEAFEYIEEIRK----
..|.....|.......                           . .|... ...|.|.                   ....  | |... |||.||    
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee

--KNGVVLIHCMAGISRSVTLTIAYLMAHFG--------MSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
  |.|.||.||.||..|. |. .|||| . .        .....|.......|| . .|.... .| |...|| 
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 200-316 1e-25 86.3 In-house 78-247 (249) alignment
Range on Protein: 200-316
Range on HMM: 78-247/249.0
NITYVLNVTPTCPNN------------------------------------------FEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK------
.||.....|......                                           .|  . .. |.. |   ....  | .....||..||      
gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelp

KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
|.|.||.||.||..|. |. .||||      . |.....|.......|| . .|.... .| |...|| .
kggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0042113 (Phosphotyrosine protein) phosphatases II 200-315 1.3e-25 85.7 In-house 76-243 (245) alignment
Range on Protein: 200-315
Range on HMM: 76-243/245.0
NITYVLNVTPTC---------------------------------------------PNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--K
.||.....|..                                              .....  ...| ..|. | |.  |.. . ...|.......  .
gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

NGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
||.||.||.||..|. |. .||||     .. |.|...|.......|| . ...... .| |...|| 
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0040438 (Phosphotyrosine protein) phosphatases II 200-318 1e-23 79.6 In-house 110-279 (317) alignment
Range on Protein: 200-318
Range on HMM: 110-279/317.0
NITYVLNVTPTCPNN--------------------------FEGAGVVYKRIPVSDT----------------GTQKLSNKFTEAFEYIEEIRKK----N
..|.....|......                          .| ||... ...|.|.                  ...   ... .. .|..|..    .
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

GVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNP
|.||.||.||..|. |. .||||      . |.....|..... .|| . ...... .| ....|. |. 
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0039614 (Phosphotyrosine protein) phosphatases II 200-316 2.5e-23 78.4 In-house 125-290 (297) alignment
Range on Protein: 200-316
Range on HMM: 125-290/297.0
NITYVLNVTPTCPNN------------------------FEGAGVV-----------------YKRIPVSDTGTQKLSNKFTEAFEYIEEIRK---KNGV
..|.....|......                        .. .|..                 .  ..  | |.  ... . |..|...|...   |.|.
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
||.||.||..|. |. .||||      . |.....|..... .|| . ...... .| ....|| |
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0036941 (Phosphotyrosine protein) phosphatases II 200-317 2.3e-20 68.5 In-house 102-279 (297) alignment
Range on Protein: 200-317
Range on HMM: 102-279/297.0
NITYVLNVTPTCPNNFE------------------------------GAGVVYKRIPVSD----------------TGTQKLSNKFTEAFEYIEEIRK--
|.| ....|.  ....|                               .....  . |.|                    .. . ... ...||..||  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----KNGVVLIHCMAGISRSVTLTIAYLM--------AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
    ..|.||.||.||..|| |. .|.||         . |... .|.......|| . ..|... .| |.. || |.
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

subfamily_DSP23_pd Subfamily DSP23 200-296 5.1e-09 31.0 In-house 31-127 (148) alignment
Range on Protein: 200-296
Range on HMM: 31-127/148.0
NITYVLNVTPTCPNNFEG-AGVVYKRIPVSDTGTQKLsNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA
 . |.. .|  .. . |   .. ..|. . |     | ..  |  . .||  .||  | .||. |  |. |.   ||. . ...  .|   |. .|| 
gvrylvslteegrphveatpnltlvrlriddyhppal.eqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg

0038934 (Phosphotyrosine protein) phosphatases II 201-318 1.9e-25 85.1 In-house 57-180 (194) alignment
Range on Protein: 201-318
Range on HMM: 57-180/194.0
ITYVLNVTPT----CPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--KNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKR
...|...| |     |. ||.||. | ..|. | ||    .  .. .. ..|. .  ..|||..||.||..|. || .|||. ..|||...|......||
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

PAISPNLNFMGQLVEFERELQKNP
| . || ... .|... .|| |..
pgaipnqdyleallkrykelrkav

0043336 (Phosphotyrosine protein) phosphatases II 201-314 1.7e-20 69.1 In-house 158-276 (278) alignment
Range on Protein: 201-314
Range on HMM: 158-276/278.0
ITYVLNVTP-TCPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRK-KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDK
....|.||.  ... ... .. |. .|  | |.    . . .  ... |... .||.||.||.||..|. |. ..||.      . |.....|..... .
tvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq

RPAISPNLNFMGQLVEFEREL
|| . ...... .| |...|.
Rpgavqtpsqyrflyealley

0047943 (Phosphotyrosine protein) phosphatases II 201-309 1.5e-16 56.2 In-house 151-266 (273) alignment
Range on Protein: 201-309
Range on HMM: 151-266/273.0
ITYVLNVTP-TCPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRK---KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVK
....| .|.  ... ..   . |. .|  | |.    . . | .|.......   .||.|..||.||..|. |. ...|.     .. |... .|.....
tvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

DKRPAISPNLNFMGQLVE
..|| . ...... .| |
sqRpgmvqtpeqyrflye

0046845 (Phosphotyrosine protein) phosphatases II 201-302 5.1e-14 47.8 In-house 149-261 (284) alignment
Range on Protein: 201-302
Range on HMM: 149-261/284.0
ITYVLNVTPT--CPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRKK---NGVVLIHCMAGISRSVTLTIAYLMAHF--------GMSMQDAY
....| .|..  . . ..     |. .|  | |.   .. . | .....|....   .|....||.||..|. |. ...|. .         |.....|.
tvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleav

QFVKDKRPAISPNLN
......||    .| 
krlreqRpgmvqtle

0049772 (Phosphotyrosine protein) phosphatases II 202-315 2.6e-34 114.8 In-house 167-274 (314) alignment
Range on Protein: 202-315
Range on HMM: 167-274/314.0
TyvlnvtPTC--PNNFEGAGVVYKRIPVSDtGTQKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVT-LTIAYLMAHFGMSMQDAYQFVKDKRPaIS
       . .  |. ||..|. |.||||.| |.. |.. | |..|.|||  .|.|.||.||.||..|. | ...|||| ..|.|...|...|. ||| |.
k......eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.in

PNLNFMGQLVEFERELQ
|| .|. || ..| .|.
pnpgfieqleqyefile

0051299 (Phosphotyrosine protein) phosphatases II 202-302 1.3e-13 46.5 In-house 164-273 (288) alignment
Range on Protein: 202-302
Range on HMM: 164-273/288.0
TYVLNVTP-----TCPNNFEGAGVVYKRIPvsDTGTQKlsnKFTEAFEYIEEIRKK----NGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAY
...| ||.      . . ..     |. .|  | |.      ... .......||.    .|.|..||.||..|. |. ...|.     .. |... .|.
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

QFVKDKRPAISPNLN
.... .|| . ....
krlreqRpgmvqtpe

subfamily_PTPMT1_pd Subfamily PTPMT1 203-316 3.7e-18 60.5 In-house 57-170 (171) alignment
Range on Protein: 203-316
Range on HMM: 57-170/171.0
YVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLN
| |..   . ....  || . .... |   .   .| ... |.||....|   | .|| || .|| || ..||| .  .|...| ...|.||. |  . .
yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakk

FMGQLVEFERELQK
 . .| |.|..|..
qwkalqeyeeklls

subfamily_Laforin_pd Subfamily Laforin 210-297 2.6e-08 26.9 In-house 67-154 (183) alignment
Range on Protein: 210-297
Range on HMM: 67-154/183.0
TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAI
|  . .   |. |  .|. |  |.   ... .|   .  . .|  .| .|| ||. || ..   .|.  .| |..    |.  |||..
tlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

subfamily_DSP11_pd Subfamily DSP11 212-296 4.5e-08 27.2 In-house 72-159 (178) alignment
Range on Protein: 212-296
Range on HMM: 72-159/178.0
PNNFEGAGVVYKRIPV--SDTGTQKLSNKFTEAF-EYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA
.....  || |... .   .. ...| .||.||  |..|.  ... .. .||  |. |.  |   ||. . |.. .|| .  .. |  
kkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh

subfamily_PTPDC1_pd Subfamily PTPDC1 212-311 7e-08 27.1 In-house 75-172 (182) alignment
Range on Protein: 212-311
Range on HMM: 75-172/182.0
PNNFEGAGVVYKRIPVSDTGTQKLSNKFTeAFEyIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFE
....  .|...  .. .| |.. | . ..     . .   ..| | .|| ||  |   |  .||. .  .. ..| ..|..|||      . .  ..||.
lealmeqgiyvynfgwkDygvasleriLd.ivk.vvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefa





0050432 (Phosphotyrosine protein) phosphatases II 213-301 8.2e-13 43.8 In-house 195-285 (308) alignment
Range on Protein: 213-301
Range on HMM: 195-285/308.0
NNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRkKNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNL
. ..     |.  |  | |.    . . . .|.... . ..|....||.||..|. |. ...|.     .. |.....|..... .||   ...
esrtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_RNGTT_pd Subfamily RNGTT 213-308 8.1e-07 22.9 In-house 71-168 (189) alignment
Range on Protein: 213-308
Range on HMM: 71-168/189.0
NNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEI--RKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLV
...|  |. |... .   | .  ... .|  . .||   .. . |. .||  |  |.  | ..||. .  .|...| .  .  ||    . ... .|.
eelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkell

PTPlike_phytase Inositol hexakisphosphate 215-276 7.2e-07 23.9 Pfam-A 88-147 (149) alignment
Range on Protein: 215-276
Range on HMM: 88-147/149.0
FEGAGVVYKRIPVSDTGTqKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVTLTIAYLM
.|| || | |||..|       ... . ...|... ...  ....| ||  |. | .. . .
aegfgvkYvRipitdeqa.peeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

PTPlike_phytase Inositol hexakisphosphate 215-276 7.2e-07 23.9 In-house 88-147 (149) alignment
Range on Protein: 215-276
Range on HMM: 88-147/149.0
FEGAGVVYKRIPVSDTGTqKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVTLTIAYLM
.|| || | |||..|       ... . ...|... ...  ....| ||  |. | .. . .
aegfgvkYvRipitdeqa.peeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 215-275 4.2e-06 18.0 Pfam-A 96-155 (168) alignment
Range on Protein: 215-275
Range on HMM: 96-155/168.0
FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
..  |.| .. |..| ||  ..   .| .| .    |..   ||||  |. ||. .. . |
yqqygivthhhpiadggtpdias.cleimeelatclknyrktlihcygglgrsclvaacll

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 215-275 4.2e-06 18.0 In-house 96-155 (168) alignment
Range on Protein: 215-275
Range on HMM: 96-155/168.0
FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
..  |.| .. |..| ||  ..   .| .| .    |..   ||||  |. ||. .. . |
yqqygivthhhpiadggtpdias.cleimeelatclknyrktlihcygglgrsclvaacll

subfamily_MSG5_pd Subfamily MSG5 218-317 1.3e-17 57.4 In-house 66-163 (165) alignment
Range on Protein: 218-317
Range on HMM: 66-163/165.0
AGVVYKRIPVsdTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
  | |  |    . . |.   ...  . |   . |.  .|.||  |.||| .| .||.| ....|..|||. .| .   |||.. .. ||.|.|  |.|.
pavkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk





subfamily_STYX_pd Subfamily STYX 220-312 1.3e-20 67.2 In-house 63-155 (166) alignment
Range on Protein: 220-312
Range on HMM: 63-155/166.0
VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
  |  . |.|. ....   . .  |.|..  .| | ||.|  |||||| .| |||.|  .|.  ..|...|...|  |.||  |. || |.| 
frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 220-316 2.1e-20 66.3 In-house 47-143 (145) alignment
Range on Protein: 220-316
Range on HMM: 47-143/145.0
VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
.    |  .|  .  ||..| |  ..|.  ...   |..|||||.|||||...|.|| . .|.. .| . |. .|    ||..|. .|...|..|..
ieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlke

PTPc_DSPc_SM00012 222-282 1.8e-08 29.9 In-house 5-68 (105) alignment
Range on Protein: 222-282
Range on HMM: 5-68/105.0
YKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKN---GVVLIHCMAGISRSVTLTIAYLMAHFGMS
|.    .|.|. . |....|....... ..|.   . |..|| ||..|. |.. .... .  ..
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek

Y_phosphatase Protein-tyrosine phosphatase 229-279 5.3e-06 21.4 Pfam-A 145-197 (235) alignment
Range on Protein: 229-279
Range on HMM: 145-197/235.0
DTGTQKLSNKFTeafEYIEEIRKKN----GVVLIHCMAGISRSVTLTIAYLM-AHF
| |... .....   ..|....|..    | |..||.||..|. |.  . ..  ..
dhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

Y_phosphatase Protein-tyrosine phosphatase 229-279 5.3e-06 21.4 In-house 145-197 (235) alignment
Range on Protein: 229-279
Range on HMM: 145-197/235.0
DTGTQKLSNKFTeafEYIEEIRKKN----GVVLIHCMAGISRSVTLTIAYLM-AHF
| |... .....   ..|....|..    | |..||.||..|. |.  . ..  ..
dhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

subfamily_CDC14_pd Subfamily CDC14 238-297 2.1e-08 28.4 In-house 254-309 (328) alignment
Range on Protein: 238-297
Range on HMM: 254-309/328.0
KFTEAFEYIeeirkkNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA--I
||.|. | .      .| . .|| ||. |  ||  .||| |.... ..|  ...  ||   |
kfleiaeka......eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvi

0048567 (Phosphotyrosine protein) phosphatases II 243-299 1.1e-09 32.9 In-house 64-123 (157) alignment
Range on Protein: 243-299
Range on HMM: 64-123/157.0
FEYIEEIRKKNGVVLIHCMAGI---SRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISP
 .... ........ .|| ||    .|..||  .||. |.|.. ..|.....  || . |
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp

subfamily_PTEN_pd Subfamily PTEN 244-294 3.6e-06 22.1 In-house 107-156 (184) alignment
Range on Protein: 244-294
Range on HMM: 107-156/184.0
EYIEEirKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQ-DAYQFVKDKR
...||  .|. || .||.||  |. .|..|||. .  .. . .| .. . .|
kwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR

subfamily_PRL_pd Subfamily PRL 250-295 9.5e-07 23.0 In-house 87-131 (151) alignment
Range on Protein: 250-295
Range on HMM: 87-131/151.0
RKKNGVVLIHCMAGISRSVTLTIAYLMaHFGMSMQDAYQFVKDKRP
.. . .| .||.||. |.  |    |.   ||...|| .|...|| 
eepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrr