Gene DSP10 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP005_AA protein Get Run
AqueP005_AA_172-318 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 15-131 6.5e-14 44.4 Pfam-A 2-110 (113) alignment 
Range on Protein: 15-131
Range on HMM: 2-110/113.0
PHQLARNLhSREDYVLLDCRPVLAYNNCHISGAVNVNFTGLMKKRFIAGKIGLADLVTTEEGRERFRKSVssptVVYDedtkDVKLLGSSTSISLVLAAL
. .|...|   |..||||.|.  .|.  || |||||..  |...|    |  ||. . . . .    | |    |||.      .  .. .  .|. . |
akelkell.ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktv....vvyc....rsgnrsggaaalllalil

TTMGR-NMFVLQGGLNAF
  .|  |..|| ||..|.
kelgyknvyvLdGGfeaw
0045098 (Phosphotyrosine protein) phosphatases II 157-316 8.3e-27 89.7 In-house 4-273 (278) alignment 
Range on Protein: 157-316
Range on HMM: 4-273/278.0
RASTPGMRDQALDWHTAPPVNVLSFLVLGSEK-----------------------------------------DARSKLVFDWFNITYVLNVTPTC----
.||.. . .    ... .|  .. .| ||. .                                          |     .   .||.....|.      
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

--------------------------------------------PNNFEGAGVVYKRI-PVSDTGTQKLS--NKFTEAFEYIEEIRK-------------
                                            ....| .|| .  . |. | |.  |.  . | |..|.|.| .|             
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

-KNGVVLIHCMAGISRSVTLTIAYLMAHF---GMSMQDAYQFVKDKRPA-ISPNLNFMGQLVEFERELQK
 ..|.||.||.||..|. || .|||| .    |.....|..... .||  . .||... .| ||..|| .
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_DSP10_pd Subfamily DSP10 163-319 1.6e-78 256.1 In-house 2-158 (159) alignment 
Range on Protein: 163-319
Range on HMM: 2-158/159.0
MRDQALDWHTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMA
..... |..||| ..||.||.|||||||... ..|..|||.|||||...||.||.... |||||||||..|.|...|.||.|.|||.|||.  ||.||.|
lspteadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqa

GISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNPS
|||||.|..|||||.|...|..|||.|||.|||.|||||||||||.|||.||.|. .
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
subfamily_LRR-DSP_pd Subfamily LRR-DSP 166-316 7.1e-28 91.4 In-house 111-260 (263) alignment 
Range on Protein: 166-316
Range on HMM: 111-260/263.0
QALDWHTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRI-PVSDTGTQKLSNKFTEAFEYIEEIRKKNGvVLIHCMAGI
. . . .. | ...  | ||. . |  | ..   ..|..|     .   |      |  |  . |.   ..|. | |   .||| ||| | ||.|| ||.
slitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfP.klfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGv

SRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
||| ||.|.||| .  . ...|. .|. ||| | ||  |. ||  .|..| .
srsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_STYXL1_pd Subfamily STYXL1 167-315 6.1e-25 81.3 In-house 3-154 (157) alignment 
Range on Protein: 167-315
Range on HMM: 3-154/157.0
ALDWHTAPPVNVL-SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVV--YKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAG
 ||  .  ||.|| ..| || .|.| .. .   . .  ..||.  . . ..|   |    .|.|.|.   .| ... || ..||. .|.. |||.    |
eldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkG

ISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
||||... ||||| .  .....||...|. .. . || .|. || |.|..| 
isrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0041856 (Phosphotyrosine protein) phosphatases II 168-318 1.4e-33 111.4 In-house 12-176 (182) alignment 
Range on Protein: 168-318
Range on HMM: 12-176/182.0
LDWHTAPPVNVLSFLVLGSEKD--------------ARSKLVFDWFNITYVLNVTPTC--PNNFEGAGVVYKRIPVSDTGTQKlsnkFTEAFEYIEEIRK
  .|. ..  ..  |.||| ..              |.    .   .||...|.|. .  |...| .|. |...|. | |.      . |....|||...
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

KNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRP--AISPNLNFMGQLVEFERELQKNP
..|.||.||.||..|. || .|||| . |.|...|...|. .||   |.|| .|. ||...|. |.|. 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0037934 (Phosphotyrosine protein) phosphatases II 168-314 2.9e-27 91.2 In-house 32-241 (243) alignment 
Range on Protein: 168-314
Range on HMM: 32-241/243.0
LDWHTAPPVNVLSFLVLGSE--------KDARSKLVFDWFNITYVLNVTPTC--------------------------------------------PNNF
 |.  |  ..|.  | ...         ..|     .   .||.....|...                                            ....
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

EGAGVVYKRIPVSD----TGTQKLSNKFTEAFEYIEE-----IRKKNGVVLIHCMAGISRSVTLTIAYLMAHF-GMSMQDAYQFVKDKRPA-ISPNLNFM
.  .. | ..|. |    . .. | . . |. |.|||      ....|.||.||.||..|. || .|||| .  |.....|.......||  . ......
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

GQLVEFEREL
 .| |...||
rflyeallel
subfamily_DSP6_pd Subfamily DSP6 171-317 8e-55 178.7 In-house 10-157 (158) alignment 
Range on Protein: 171-317
Range on HMM: 10-157/158.0
HTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAG-VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVT
... ||..|..| |||.|||    |.. ..| ||||||.  || || .| . |..||..|  .|.|.. | ||.|.|.| |.|.  ||.||.||||||||
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
.|.|||| .  .|..|||..||.... ||||.||||||..|||.|. .
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
subfamily_DSP8_pd Subfamily DSP8 171-316 8.9e-46 149.3 In-house 11-156 (159) alignment 
Range on Protein: 171-316
Range on HMM: 11-156/159.0
HTAPPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTL
..  | ..| .| |||.||. |. ...  .|.||||.  .||.  |   . . |.|| |. . ||.. | ...|.|. ....|| ||.|..|||||| |.
advgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatv

TIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
 |||.| .. ||...||.|||.|||.|||||||.|||.|.|.||..
aiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0044763 (Phosphotyrosine protein) phosphatases II 173-318 1.7e-39 130.6 In-house 21-174 (178) alignment 
Range on Protein: 173-318
Range on HMM: 21-174/178.0
APPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT--------CPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIR-KKNGVVLIHCMAG
 ... .| .| |||  .|. .  .   .||...|.|..        .|  .|.||. |..||..| |.. |.  | |..|.|||.. .|.|.||.||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPaISPNLNFMGQLVEFERELQKNP
..|| || .|||| ..|.|...|...|. .|| |.|| ... || |||..|.|..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
PTEN_1 173-317 2.9e-32 107.1 In-house 35-194 (196) alignment 
Range on Protein: 173-317
Range on HMM: 35-194/196.0
AP-----PvNVLSFLVLGSEKDARSKL-VFDWFNITYVLNVTPTCPN--------NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--KNGVV
||        .  .| .||.||... |  ..  .|| |.|... ...         |.  || |...|. | |.. ||  | .. . || ...  ...||
apsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvV

LIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
|.|| ||..||.|. .||||.. ......| ..|..|||...||  .. .|.|...||...
lVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_DSP1_pd Subfamily DSP1 174-316 3.1e-45 148.2 In-house 16-158 (163) alignment 
Range on Protein: 174-316
Range on HMM: 16-158/163.0
PPVN-VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGaGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTI
 ||. .| || ||||..|  . . .  .|| .|||. ...| ||     ||.....|. .. .|  |.|. |.|.|..|||| ||||| |||||| || .
dPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
|||| .  .|...|..|||..|. ||||..|..||...|..|..
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_Slingshot_pd Subfamily Slingshot 174-314 9.7e-33 106.9 In-house 18-157 (169) alignment 
Range on Protein: 174-314
Range on HMM: 18-157/169.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAgVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
 . ..  .. |||| .|     ..  ...|.||||  . | |..  . |..| | |. ...| ... |....||. .||.  ||.||  |.||| .  ||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpek.feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
| | ..|.|...|...||..|  | || .|. || |.|  |
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_MKPLT_pd Subfamily MKPLT 174-312 4.4e-27 88.6 In-house 21-158 (164) alignment 
Range on Protein: 174-312
Range on HMM: 21-158/164.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
| | .   | ||  |.|... | .  .||...||.  . ..|    |.| .. |.|. ...||. .  | ... .  .  | ||.||  | ||| . |.|
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|.   |  ...||...|..|  ..||  |. || .||.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 174-312 4.4e-27 88.6 In-house 21-158 (164) alignment 
Range on Protein: 174-312
Range on HMM: 21-158/164.0
PPVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
| | .   | ||  |.|... | .  .||...||.  . ..|    |.| .. |.|. ...||. .  | ... .  .  | ||.||  | ||| . |.|
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|.   |  ...||...|..|  ..||  |. || .||.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
PTPc_motif_SM00404 175-312 5.1e-43 141.3 In-house 2-139 (140) alignment 
Range on Protein: 175-312
Range on HMM: 2-139/140.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAY
| ..|  | |||...| .. . . ..||.|.||| ..... |  |. ...||..|....|||... .. ..||...||.| ||.||.||.|||.||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
||   ..|...||.|||..||.|||||||. ||.|.|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048076 (Phosphotyrosine protein) phosphatases II 175-315 6.8e-35 115.2 In-house 4-143 (145) alignment 
Range on Protein: 175-315
Range on HMM: 4-143/145.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPnNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAY
|  .|  | |||  .|..   .  ..||.|||.|.... ..|  |. | ..|. | |.. |.. . |..|.|||..|..|.||.||.||..|. || .||
pseilpglylgslptaldlellkdlgittvlnltsele.llerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
|| ..|.|...|...|. .|| . || ... .| |||.||.
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0048179 (Phosphotyrosine protein) phosphatases II 175-313 1.6e-34 114.0 In-house 4-143 (144) alignment 
Range on Protein: 175-313
Range on HMM: 4-143/144.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGA-GVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIA
|. .|. | |||  .|..   .  ..||.|.|.|......|..  |. | ..|. | |.  |.. . |..|.|||.....|.||.||.||..|. || .|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERE
||| ..|.|...|...|. .|| . || ... .| |.|..
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0043147 (Phosphotyrosine protein) phosphatases II 175-314 3.2e-34 113.5 In-house 19-160 (172) alignment 
Range on Protein: 175-314
Range on HMM: 19-160/172.0
PVNVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT--CPNNFEGAGVVYKRIPVSDTGTQkLSNKFTEAFEYIEE--IRKKNGVVLIHCMAGISRSVTL
| ... .. .... .|     .   .||...|.|.    | ..|  |. | ..|. | |.. |.. . |..|.|.|  .....|.||.||.||..|..||
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

TIAYLMAhFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
 .||||   |.|...|...|..||| ...| ... .| .||. |
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP19_pd Subfamily DSP19 177-315 9.2e-37 120.7 In-house 14-151 (152) alignment 
Range on Protein: 177-315
Range on HMM: 14-151/152.0
NVLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEgAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLM
.|   | |||   | .|  ..  .||..|||.   || |    . |. |.. |.  ..|.. . ||...||| |.|.|.||.|| ||.|||... |||||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp.kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
..  .|...|.. |...||.|.||  |. || |.| ||.
kkeelsleealelvrearpcikPneGFikqLkeyeaell
subfamily_DSP14_pd Subfamily DSP14 178-319 5.3e-38 124.4 In-house 10-149 (157) alignment 
Range on Protein: 178-319
Range on HMM: 10-149/157.0
VLSFLVLGsEKDARSKLVFDWFNITYVLNVTPTCPNnFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMA
. . | |.    |.|| ...  .|| ..|||.  ||  .  .. . ..||.|. ..||.. | |. ..|||..||.| .|.||.||.||| .|..|||| 
itpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmk

HFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNPS
.  .|...||. ||..|| |.||. |  ||...|..|... |
yeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss
subfamily_DSP15_pd Subfamily DSP15 178-314 3.3e-32 105.6 In-house 5-139 (151) alignment 
Range on Protein: 178-314
Range on HMM: 5-139/151.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGagVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMA
||  | ||  .|.. .   .  ||| .|.|     . ..   . || |..|||  .|||. | |. |.| . | |.. ||.||.||.||||||..||||.
vlpglylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

HFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
   .. .|| ...| .|    ||. |  || |.|.  
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_DSP12_pd Subfamily DSP12 178-315 7.7e-32 104.8 In-house 5-144 (155) alignment 
Range on Protein: 178-315
Range on HMM: 5-144/155.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPT-CPNNFEGAGVVY-KRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
.|  | ||. ... ..   . ..|| || |. .  |.  . .| |. | |.. |. .. . . . ||...||| ....| ||.||.||.|||||. ||||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
| . ..|...|...||.|.| |.|| .|. ||  ||.   
mkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
subfamily_DSP3_pd Subfamily DSP3 178-317 2.2e-29 96.2 In-house 14-160 (162) alignment 
Range on Protein: 178-317
Range on HMM: 14-160/162.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTP-------TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEE-IRKKNGVVLIHCMAGISRSVT
|   | .| |. |. |  .  . ||.||| .        | .. ...... |  ..|.|. . .||. |..|...|.| . .|.| ||.||..|.||| |
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

LTIAYLMAHFGMSMQDAYQFVKDKRpAISPNLNFMGQLVEFERELQKN
| .|||| .  |....| . |..|| .| ||  |. ||.|...||...
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 178-315 2.6e-26 85.8 In-house 6-153 (154) alignment 
Range on Protein: 178-315
Range on HMM: 6-153/154.0
VLSFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGA------G--VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIR--KKNGVVLIHCMAGISRS
. .|| ..| . |  || ..  ||. .|||    .| |         |  . | .. . |   ... .|.  |||.|..     .|. ||.|. .|.|||
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

VTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
 .| |.||| .  .|.  |....|| |. |.||  |. ||  ||.||.
aallisylmdklkislslalellkdsryiikPnqGflkqleifekell
0049260 (Phosphotyrosine protein) phosphatases II 180-314 2.6e-30 100.5 In-house 13-149 (152) alignment 
Range on Protein: 180-314
Range on HMM: 13-149/152.0
SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNF--EGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEE-IRKKNGVVLIHCMAGISRSVTLTIAYLM
 .. .|..  |  .  .   .||.....|  .....  .  .  |...|. | |...||  . .... ||. ...|.|.||.||.||..|. || .||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

AhFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
  .|.|...|...|. ||| . || ... .| |||. |
l.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 180-312 5.9e-30 97.7 In-house 13-145 (148) alignment 
Range on Protein: 180-312
Range on HMM: 13-145/148.0
SFLVLGSEKDARSKLVFDWFNITYVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHF
.|| ||| | | .  .   ...| . | |  ..| ..  |. |  ....|   . ||  | .. ..... ... . ||.|.  |.|||  |....|. . 
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

GMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
 .|...|...||.||. . ||| |. || |.|.
rvslkealalvkskrryvdpnlgfLkqLaeleq
DSPc Dual specificity phosphatase, catalytic domain 183-312 4.7e-40 131.5 Pfam-A 2-132 (133) alignment 
Range on Protein: 183-312
Range on HMM: 2-132/133.0
VLGSEKDARsKLVFDWFNITYVLNVTPTCPN--NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFG
 |||...|  . . . ..||.|.||| ..||   ..     | |||| |. ..|.|... || |.||....|.. ||.||.|||||| ||.|||||  ..
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|...||.|||..|..|||| .|..||.|.||
lslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 183-312 4.7e-40 131.5 In-house 2-132 (133) alignment 
Range on Protein: 183-312
Range on HMM: 2-132/133.0
VLGSEKDARsKLVFDWFNITYVLNVTPTCPN--NFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFG
 |||...|  . . . ..||.|.||| ..||   ..     | |||| |. ..|.|... || |.||....|.. ||.||.|||||| ||.|||||  ..
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
.|...||.|||..|..|||| .|..||.|.||
lslneAyefvkerrskispnagflrqLleyer
0051082 (Phosphotyrosine protein) phosphatases II 189-310 5e-24 80.0 In-house 22-149 (151) alignment 
Range on Protein: 189-310
Range on HMM: 22-149/151.0
DARSKLVFDWFNITYVLNVTP-----TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKK-NGVVLIHCMAGISRSVTLTIAYLMAhFGMS
 |.    .   .|....|...     .||. .. .|. ...||. |. ...|.  | .. |..|....| ||.||.||.||..|. || ..|||.  |.|
ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvs

MQDAYQFVKDKRP-AISPNLNFMGQLVEF
...|..... ||| .. ||  |. || ..
leealeeyrlkrpgvvqpnqqflfqlfal
0046846 (Phosphotyrosine protein) phosphatases II 194-317 2.4e-30 101.0 In-house 42-175 (176) alignment 
Range on Protein: 194-317
Range on HMM: 42-175/176.0
LVFDWfNITYVLNVTPT----------CPNNFEGAGVVYKRIPVSDTGTQKLsNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAH-FGMS
..... .||.|.|.|             .. .|..|. |...|. | |.  | . . |..|.|.| .|..|.||.||.|||.|. || .|||. . .|.|
mlkel.gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekgls

MQDAYQFVKDKRP-AISPNLNFMGQLVEFERELQKN
...|...|...||  . .. ... .| |||..|.|.
veealalvreqRplgavqtpeQyrflyefellllkk
0036282 (Phosphotyrosine protein) phosphatases II 199-314 1.4e-28 95.1 In-house 35-169 (174) alignment 
Range on Protein: 199-314
Range on HMM: 35-169/174.0
FNITYVLNVTPTCPNN--------------FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKK--NGVVLIHCMAGISRSVTLTIAYLMAHFGM-
..||.|..... ....              .|  |. |...|. | |.  ||  . |.....||....  .|.||.||.||..|. || .|||| . .. 
lgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglle

SMQDAYQFVKDKR---PAISPNLNFMGQLVEFEREL
|..||...|. .|   | . .. ... .| .||. |
slvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0051429 (Phosphotyrosine protein) phosphatases II 199-314 8.1e-20 67.0 In-house 44-224 (272) alignment 
Range on Protein: 199-314
Range on HMM: 44-224/272.0
FNITYVLNVTPTCPNNFEG-----AGVVYKRIPVSDTGTQKLS---------------------------------------------------NKFTEA
 .|..........  ....     .|. | ..|. |....  .                                                   . . |.
lgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallel

FEYIEEirkkNGVVLIHCMAGISRSVTLTIAYLMAhFGMS--------------MQDAYQFVKDKRPAISPNLNFMGQLVEFEREL
.|.. .    .| ||.||.||..|. |.  ..|..  |.|              ...|.. ....||.. ..  .. .| |...||
lellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 200-315 5.3e-26 87.5 In-house 131-304 (307) alignment 
Range on Protein: 200-315
Range on HMM: 131-304/307.0
NITYVLNVTPTCPNNF---------------------------EGAGVVYKRIPVSDT-----------------GTQKLSNKFTEAFEYIEEIRK----
..|.....|.......                           . .|... ...|.|.                   ....  | |... |||.||    
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee

--KNGVVLIHCMAGISRSVTLTIAYLMAHFG--------MSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
  |.|.||.||.||..|. |. .|||| . .        .....|.......|| . .|.... .| |...|| 
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 200-316 1e-25 86.3 In-house 78-247 (249) alignment 
Range on Protein: 200-316
Range on HMM: 78-247/249.0
NITYVLNVTPTCPNN------------------------------------------FEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK------
.||.....|......                                           .|  . .. |.. |   ....  | .....||..||      
gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelp

KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
|.|.||.||.||..|. |. .||||      . |.....|.......|| . .|.... .| |...|| .
kggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 200-315 1.3e-25 85.7 In-house 76-243 (245) alignment 
Range on Protein: 200-315
Range on HMM: 76-243/245.0
NITYVLNVTPTC---------------------------------------------PNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--K
.||.....|..                                              .....  ...| ..|. | |.  |.. . ...|.......  .
gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

NGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQ
||.||.||.||..|. |. .||||     .. |.|...|.......|| . ...... .| |...|| 
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 200-318 1e-23 79.6 In-house 110-279 (317) alignment 
Range on Protein: 200-318
Range on HMM: 110-279/317.0
NITYVLNVTPTCPNN--------------------------FEGAGVVYKRIPVSDT----------------GTQKLSNKFTEAFEYIEEIRKK----N
..|.....|......                          .| ||... ...|.|.                  ...   ... .. .|..|..    .
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

GVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKNP
|.||.||.||..|. |. .||||      . |.....|..... .|| . ...... .| ....|. |. 
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0039614 (Phosphotyrosine protein) phosphatases II 200-316 2.5e-23 78.4 In-house 125-290 (297) alignment 
Range on Protein: 200-316
Range on HMM: 125-290/297.0
NITYVLNVTPTCPNN------------------------FEGAGVV-----------------YKRIPVSDTGTQKLSNKFTEAFEYIEEIRK---KNGV
..|.....|......                        .. .|..                 .  ..  | |.  ... . |..|...|...   |.|.
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
||.||.||..|. |. .||||      . |.....|..... .|| . ...... .| ....|| |
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0036941 (Phosphotyrosine protein) phosphatases II 200-317 2.3e-20 68.5 In-house 102-279 (297) alignment 
Range on Protein: 200-317
Range on HMM: 102-279/297.0
NITYVLNVTPTCPNNFE------------------------------GAGVVYKRIPVSD----------------TGTQKLSNKFTEAFEYIEEIRK--
|.| ....|.  ....|                               .....  . |.|                    .. . ... ...||..||  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----KNGVVLIHCMAGISRSVTLTIAYLM--------AHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
    ..|.||.||.||..|| |. .|.||         . |... .|.......|| . ..|... .| |.. || |.
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_DSP23_pd Subfamily DSP23 200-296 5.1e-09 31.0 In-house 31-127 (148) alignment 
Range on Protein: 200-296
Range on HMM: 31-127/148.0
NITYVLNVTPTCPNNFEG-AGVVYKRIPVSDTGTQKLsNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA
 . |.. .|  .. . |   .. ..|. . |     | ..  |  . .||  .||  | .||. |  |. |.   ||. . ...  .|   |. .|| 
gvrylvslteegrphveatpnltlvrlriddyhppal.eqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
0038934 (Phosphotyrosine protein) phosphatases II 201-318 1.9e-25 85.1 In-house 57-180 (194) alignment 
Range on Protein: 201-318
Range on HMM: 57-180/194.0
ITYVLNVTPT----CPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRK--KNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKR
...|...| |     |. ||.||. | ..|. | ||    .  .. .. ..|. .  ..|||..||.||..|. || .|||. ..|||...|......||
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

PAISPNLNFMGQLVEFERELQKNP
| . || ... .|... .|| |..
pgaipnqdyleallkrykelrkav
0043336 (Phosphotyrosine protein) phosphatases II 201-314 1.7e-20 69.1 In-house 158-276 (278) alignment 
Range on Protein: 201-314
Range on HMM: 158-276/278.0
ITYVLNVTP-TCPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRK-KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDK
....|.||.  ... ... .. |. .|  | |.    . . .  ... |... .||.||.||.||..|. |. ..||.      . |.....|..... .
tvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq

RPAISPNLNFMGQLVEFEREL
|| . ...... .| |...|.
Rpgavqtpsqyrflyealley
0047943 (Phosphotyrosine protein) phosphatases II 201-309 1.5e-16 56.2 In-house 151-266 (273) alignment 
Range on Protein: 201-309
Range on HMM: 151-266/273.0
ITYVLNVTP-TCPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRK---KNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVK
....| .|.  ... ..   . |. .|  | |.    . . | .|.......   .||.|..||.||..|. |. ...|.     .. |... .|.....
tvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

DKRPAISPNLNFMGQLVE
..|| . ...... .| |
sqRpgmvqtpeqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 201-302 5.1e-14 47.8 In-house 149-261 (284) alignment 
Range on Protein: 201-302
Range on HMM: 149-261/284.0
ITYVLNVTPT--CPNNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRKK---NGVVLIHCMAGISRSVTLTIAYLMAHF--------GMSMQDAY
....| .|..  . . ..     |. .|  | |.   .. . | .....|....   .|....||.||..|. |. ...|. .         |.....|.
tvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleav

QFVKDKRPAISPNLN
......||    .| 
krlreqRpgmvqtle
0049772 (Phosphotyrosine protein) phosphatases II 202-315 2.6e-34 114.8 In-house 167-274 (314) alignment 
Range on Protein: 202-315
Range on HMM: 167-274/314.0
TyvlnvtPTC--PNNFEGAGVVYKRIPVSDtGTQKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVT-LTIAYLMAHFGMSMQDAYQFVKDKRPaIS
       . .  |. ||..|. |.||||.| |.. |.. | |..|.|||  .|.|.||.||.||..|. | ...|||| ..|.|...|...|. ||| |.
k......eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.in

PNLNFMGQLVEFERELQ
|| .|. || ..| .|.
pnpgfieqleqyefile
0051299 (Phosphotyrosine protein) phosphatases II 202-302 1.3e-13 46.5 In-house 164-273 (288) alignment 
Range on Protein: 202-302
Range on HMM: 164-273/288.0
TYVLNVTP-----TCPNNFEGAGVVYKRIPvsDTGTQKlsnKFTEAFEYIEEIRKK----NGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAY
...| ||.      . . ..     |. .|  | |.      ... .......||.    .|.|..||.||..|. |. ...|.     .. |... .|.
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

QFVKDKRPAISPNLN
.... .|| . ....
krlreqRpgmvqtpe
subfamily_PTPMT1_pd Subfamily PTPMT1 203-316 3.7e-18 60.5 In-house 57-170 (171) alignment 
Range on Protein: 203-316
Range on HMM: 57-170/171.0
YVLNVTPTCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLN
| |..   . ....  || . .... |   .   .| ... |.||....|   | .|| || .|| || ..||| .  .|...| ...|.||. |  . .
yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakk

FMGQLVEFERELQK
 . .| |.|..|..
qwkalqeyeeklls
subfamily_Laforin_pd Subfamily Laforin 210-297 2.6e-08 26.9 In-house 67-154 (183) alignment 
Range on Protein: 210-297
Range on HMM: 67-154/183.0
TCPNNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAI
|  . .   |. |  .|. |  |.   ... .|   .  . .|  .| .|| ||. || ..   .|.  .| |..    |.  |||..
tlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_DSP11_pd Subfamily DSP11 212-296 4.5e-08 27.2 In-house 72-159 (178) alignment 
Range on Protein: 212-296
Range on HMM: 72-159/178.0
PNNFEGAGVVYKRIPV--SDTGTQKLSNKFTEAF-EYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA
.....  || |... .   .. ...| .||.||  |..|.  ... .. .||  |. |.  |   ||. . |.. .|| .  .. |  
kkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh
subfamily_PTPDC1_pd Subfamily PTPDC1 212-311 7e-08 27.1 In-house 75-172 (182) alignment 
Range on Protein: 212-311
Range on HMM: 75-172/182.0
PNNFEGAGVVYKRIPVSDTGTQKLSNKFTeAFEyIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFE
....  .|...  .. .| |.. | . ..     . .   ..| | .|| ||  |   |  .||. .  .. ..| ..|..|||      . .  ..||.
lealmeqgiyvynfgwkDygvasleriLd.ivk.vvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefa
0050432 (Phosphotyrosine protein) phosphatases II 213-301 8.2e-13 43.8 In-house 195-285 (308) alignment 
Range on Protein: 213-301
Range on HMM: 195-285/308.0
NNFEGAGVVYKRIPvsDTGTQKLSNKFTEAFEYIEEIRkKNGVVLIHCMAGISRSVTLTIAYLM-----AHFGMSMQDAYQFVKDKRPAISPNL
. ..     |.  |  | |.    . . . .|.... . ..|....||.||..|. |. ...|.     .. |.....|..... .||   ...
esrtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_RNGTT_pd Subfamily RNGTT 213-308 8.1e-07 22.9 In-house 71-168 (189) alignment 
Range on Protein: 213-308
Range on HMM: 71-168/189.0
NNFEGAGVVYKRIPVSDTGTQKLSNKFTEAFEYIEEI--RKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLV
...|  |. |... .   | .  ... .|  . .||   .. . |. .||  |  |.  | ..||. .  .|...| .  .  ||    . ... .|.
eelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkell
PTPlike_phytase Inositol hexakisphosphate 215-276 7.2e-07 23.9 Pfam-A 88-147 (149) alignment 
Range on Protein: 215-276
Range on HMM: 88-147/149.0
FEGAGVVYKRIPVSDTGTqKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVTLTIAYLM
.|| || | |||..|       ... . ...|... ...  ....| ||  |. | .. . .
aegfgvkYvRipitdeqa.peeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 215-276 7.2e-07 23.9 In-house 88-147 (149) alignment 
Range on Protein: 215-276
Range on HMM: 88-147/149.0
FEGAGVVYKRIPVSDTGTqKLSNKFTEAFEYIEEIrKKNGVVLIHCMAGISRSVTLTIAYLM
.|| || | |||..|       ... . ...|... ...  ....| ||  |. | .. . .
aegfgvkYvRipitdeqa.peeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 215-275 4.2e-06 18.0 Pfam-A 96-155 (168) alignment 
Range on Protein: 215-275
Range on HMM: 96-155/168.0
FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
..  |.| .. |..| ||  ..   .| .| .    |..   ||||  |. ||. .. . |
yqqygivthhhpiadggtpdias.cleimeelatclknyrktlihcygglgrsclvaacll
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 215-275 4.2e-06 18.0 In-house 96-155 (168) alignment 
Range on Protein: 215-275
Range on HMM: 96-155/168.0
FEGAGVVYKRIPVSDTGTQKLSNkFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYL
..  |.| .. |..| ||  ..   .| .| .    |..   ||||  |. ||. .. . |
yqqygivthhhpiadggtpdias.cleimeelatclknyrktlihcygglgrsclvaacll
subfamily_MSG5_pd Subfamily MSG5 218-317 1.3e-17 57.4 In-house 66-163 (165) alignment 
Range on Protein: 218-317
Range on HMM: 66-163/165.0
AGVVYKRIPVsdTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQKN
  | |  |    . . |.   ...  . |   . |.  .|.||  |.||| .| .||.| ....|..|||. .| .   |||.. .. ||.|.|  |.|.
pavkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
subfamily_STYX_pd Subfamily STYX 220-312 1.3e-20 67.2 In-house 63-155 (166) alignment 
Range on Protein: 220-312
Range on HMM: 63-155/166.0
VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFER
  |  . |.|. ....   . .  |.|..  .| | ||.|  |||||| .| |||.|  .|.  ..|...|...|  |.||  |. || |.| 
frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 220-316 2.1e-20 66.3 In-house 47-143 (145) alignment 
Range on Protein: 220-316
Range on HMM: 47-143/145.0
VVYKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISPNLNFMGQLVEFERELQK
.    |  .|  .  ||..| |  ..|.  ...   |..|||||.|||||...|.|| . .|.. .| . |. .|    ||..|. .|...|..|..
ieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlke
PTPc_DSPc_SM00012 222-282 1.8e-08 29.9 In-house 5-68 (105) alignment 
Range on Protein: 222-282
Range on HMM: 5-68/105.0
YKRIPVSDTGTQKLSNKFTEAFEYIEEIRKKN---GVVLIHCMAGISRSVTLTIAYLMAHFGMS
|.    .|.|. . |....|....... ..|.   . |..|| ||..|. |.. .... .  ..
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
Y_phosphatase Protein-tyrosine phosphatase 229-279 5.3e-06 21.4 Pfam-A 145-197 (235) alignment 
Range on Protein: 229-279
Range on HMM: 145-197/235.0
DTGTQKLSNKFTeafEYIEEIRKKN----GVVLIHCMAGISRSVTLTIAYLM-AHF
| |... .....   ..|....|..    | |..||.||..|. |.  . ..  ..
dhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql
Y_phosphatase Protein-tyrosine phosphatase 229-279 5.3e-06 21.4 In-house 145-197 (235) alignment 
Range on Protein: 229-279
Range on HMM: 145-197/235.0
DTGTQKLSNKFTeafEYIEEIRKKN----GVVLIHCMAGISRSVTLTIAYLM-AHF
| |... .....   ..|....|..    | |..||.||..|. |.  . ..  ..
dhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql
subfamily_CDC14_pd Subfamily CDC14 238-297 2.1e-08 28.4 In-house 254-309 (328) alignment 
Range on Protein: 238-297
Range on HMM: 254-309/328.0
KFTEAFEYIeeirkkNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPA--I
||.|. | .      .| . .|| ||. |  ||  .||| |.... ..|  ...  ||   |
kfleiaeka......eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvi
0048567 (Phosphotyrosine protein) phosphatases II 243-299 1.1e-09 32.9 In-house 64-123 (157) alignment 
Range on Protein: 243-299
Range on HMM: 64-123/157.0
FEYIEEIRKKNGVVLIHCMAGI---SRSVTLTIAYLMAHFGMSMQDAYQFVKDKRPAISP
 .... ........ .|| ||    .|..||  .||. |.|.. ..|.....  || . |
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_PTEN_pd Subfamily PTEN 244-294 3.6e-06 22.1 In-house 107-156 (184) alignment 
Range on Protein: 244-294
Range on HMM: 107-156/184.0
EYIEEirKKNGVVLIHCMAGISRSVTLTIAYLMAHFGMSMQ-DAYQFVKDKR
...||  .|. || .||.||  |. .|..|||. .  .. . .| .. . .|
kwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_PRL_pd Subfamily PRL 250-295 9.5e-07 23.0 In-house 87-131 (151) alignment 
Range on Protein: 250-295
Range on HMM: 87-131/151.0
RKKNGVVLIHCMAGISRSVTLTIAYLMaHFGMSMQDAYQFVKDKRP
.. . .| .||.||. |.  |    |.   ||...|| .|...|| 
eepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrr