Gene DSP6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP010_AA protein Get Run
AqueP010_AA_182-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 8-127 3.1e-13 42.2 Pfam-A 4-112 (113) alignment 
Range on Protein: 8-127
Range on HMM: 4-112/113.0
WLAEQLrhHSDSVLLLDTRCSEEYKDGCIVSAVNVYCCSPlilrrlkKGNVSVESLLLCEEDKEKYSKARESEEiSVVVYDeagsSSGESDSLTSSL---
.|.|.|   ...|.|||.|  |||. |.|  ||||   |         .. .  .    .|. |.. |  ...   ||||.    .||.. . . .|   
elkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.......yprrdlffkdklaeeleesgkkldkdk.tvvvyc....rsgnrsggaaallla

--LKKLtrEAKNVSFLSGGYTGFKN
  ||.|    |||..| ||....|.
lilkel..gyknvyvLdGGfeawka
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 153-308 3.9e-08 23.8 Pfam-A 262-423 (451) alignment 
Range on Protein: 153-308
Range on HMM: 262-423/451.0
QLQNLSTVSDDSSSDSSSSDESPSPVQERRkipfmILSHLYLGCREA----ASDIEALRESGISRVLNVTSEDSK-YRSMDSFTY--YQIPVEDVHEVDM
....| . .. |...|.... ... |.. .     . ..|.||  |.    .. ..| .|. .. |...... ..   . .. ..  ...  . . . ..
lieelveeekkskaeseaervkvkavkndk.....nttelvlgkieknlaaekslvakeekevdlvislsekivsseteekkkkvlelklesskkgskeL

LQHLPEAFTFIEEARLS--GEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAY--DYVKQKKSNIS
 ..||..  ||..   |   .|..|.|. |   ||.|||  | .|.  . .        | .|. | 
rkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkkseeekkinkelir
subfamily_DSP6_pd Subfamily DSP6 178-327 1.9e-70 229.4 In-house 7-157 (158) alignment 
Range on Protein: 178-327
Range on HMM: 7-157/158.0
VQERRKIPFMILSHLYLGCREAASDIEALRESGISRVLNVTSE-DSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSR
.......|..||..||||....||..|.|....|..||||||. ..|........|.|||.||... .. ...|||..||.||| . .||.|||.||.||
kkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisr

SVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLRSS
||||.|.||||.. ...|.|||.||..||||||||.|..||..||.|||.|
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0045098 (Phosphotyrosine protein) phosphatases II 181-325 9.8e-31 102.6 In-house 18-272 (278) alignment 
Range on Protein: 181-325
Range on HMM: 18-272/278.0
RRKIPFMILSHLYLGCRE-----------------------------------------AASDIEALRESGISRVLNVTS--------------------
.  || .|. .||||...                                         .|.... |.| ||. ....|.                    
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------EDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARL--------------SGEKVIVHCHAGM
                               || . | .  . |. .|  .|.. ..|... |.. ||.||.               ||..|.|||.|| 
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSVTVVLSYLMKYY---GYTFNSAYDYVKQKKSN-ISPNFSFIQQLVQFESSLR
.|. |.|. |||...   |... .|........ . . .|......| .|.  |.
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_LRR-DSP_pd Subfamily LRR-DSP 183-325 3.2e-37 122.1 In-house 118-259 (263) alignment 
Range on Protein: 183-325
Range on HMM: 118-259/263.0
KIPFMILSHLYLGCREAASDIEALRESGISRV-LNVTSEDSKYrsMDSFTYYQI-PVEDVHEVDMLQHLPEAFTFIEEARLSGEkVIVHCHAGMSRSVTV
 .|  |. .|.||....| .   |.. |.. . | |.  .  .   . | |. |  .||| | |. ||. |  .|||| | .|  |.||| ||.||| |.
svPdeiidklflGgldsannksilkdlgvthillavadfePlf..PklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstl

VLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
|.|||||.   .|. |.| |..|...| ||  |..|| ..|  | 
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP10_pd Subfamily DSP10 184-328 1e-48 159.2 In-house 12-157 (159) alignment 
Range on Protein: 184-328
Range on HMM: 12-157/159.0
I-PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVL
.    .|..|.||  . |.|..||.. .|. |||||..  .. . ....| .|||.| .. .. |.  ||. |||||| .|..|.|||.||.|||.|||.
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

SYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLRSSP
.||||. . ..| ||..||.|.. ||||..|. ||..|| .|. | 
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
0048076 (Phosphotyrosine protein) phosphatases II 184-324 9.9e-37 121.1 In-house 3-142 (145) alignment 
Range on Protein: 184-324
Range on HMM: 3-142/145.0
IPFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRsMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLS
 | .|| .||||.  .|.|.| |.. || .|||.||| . .     ..|...|..| .. |.|..|.|.. |||||. .|..|.|||.||..|. |.|. 
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
|||...|... .|...|... ... ||......| .||  |
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0041856 (Phosphotyrosine protein) phosphatases II 184-324 1.5e-31 104.8 In-house 18-172 (182) alignment 
Range on Protein: 184-324
Range on HMM: 18-172/182.0
IPFMILSHLYLGCREA--------------ASDIEALRESGISRVLNVTsedS-----KYRSMDSFTYYQIPVEDVHEVDmlqhLPEAFTFIEEARLSGE
 . .|. .||||.. |              |.... |.| ||. ..|.|   .     ..     ..|...|..| .  |    |.|.. ||||.. .|.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

KVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQKKS--NISPNFSFIQQLVQFESSL
.|.|||.||..|. |.|. ||||..|... .|...|.....   |.||. |. ||. .|  |
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_STYXL1_pd Subfamily STYXL1 184-324 2.5e-29 95.5 In-house 10-153 (157) alignment 
Range on Protein: 184-324
Range on HMM: 10-153/157.0
IPFMIL-SHLYLGCREAASDIEALRESGISRVLNVTSE-DSKYRSMDS-FTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTV
 |  .| ..||||  . | . .  ..  .  ..||... |  . ...      .|.|||. | |.|..| ||  |||. . .|| |.|  . |.|||..|
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaav

VLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
...||| ..  |...||.|.|. |.|. || .|..|| ..| .|
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_DSP8_pd Subfamily DSP8 185-325 8.6e-44 142.9 In-house 15-155 (159) alignment 
Range on Protein: 185-325
Range on HMM: 15-155/159.0
PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSY
|  || .||||... . . |.|.. ||| |||.  .. |   .    . ..||.| .. ..|. ..... ||. |. .  .|.||..||.||| ||...|
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
.||.   ....|| .||.|.  ||||. |..||...| .|.
imktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP1_pd Subfamily DSP1 185-325 5.5e-43 140.9 In-house 17-157 (163) alignment 
Range on Protein: 185-325
Range on HMM: 17-157/163.0
PFM-ILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRsMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLS
| . || .|||| .. ||. | |.. ||. .|||..| ...   | |.|.....|| .. |. ... |.  ||.|.. .. ||..||.||.||| |..| 
PvekildfLylGsetvasnleiLkslgitailnvskeldnvf.edlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
||||   .... |.|.|||..| ||||..|..||...|..| 
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 185-326 2e-41 136.9 In-house 23-172 (178) alignment 
Range on Protein: 185-326
Range on HMM: 23-172/178.0
PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKY--------RSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEAR-LSGEKVIVHCHAGMS
. .|| .||||.  .|.|.| |.| ||. ..|.|.|.  .         .  ...|..||..| .. |.|.|..|.. |||||.  .|..|.|||.||..
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSVTVVLSYLMKYYGYTFNSAYDYVKQKKSnISPNFSFIQQLVQFESSLRS
|| |.|. ||||..|.....|...|..... |.||.....|| .||. |..
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_Slingshot_pd Subfamily Slingshot 185-327 5.4e-40 130.5 In-house 19-160 (169) alignment 
Range on Protein: 185-327
Range on HMM: 19-160/169.0
PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSmDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSY
.  |  |.|||    ||..| |.|.|.. .|||| |  .. . ..|.|..| | | .| |.|..  |...|||.|. .| ||.|||  |.||| ..|..|
askifdhvylGsewnasnleelkengveyilnvtkeidnffp.ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLRSS
 || ||.....|..|||...| | || .|..|| ..|  |..|
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGileas
0048179 (Phosphotyrosine protein) phosphatases II 185-323 5.1e-36 118.9 In-house 4-143 (144) alignment 
Range on Protein: 185-323
Range on HMM: 4-143/144.0
PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSMDS-FTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLS
| .||..||||.  .|.|.| |.. ||. |.|.|.|  ..   .  ..|...|..| .  |.|..|.|.. |||||. .|..|.|||.||..|. |.|. 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
||||..|.....|...|... ... ||......| ..|. 
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0049260 (Phosphotyrosine protein) phosphatases II 185-324 1.3e-32 107.9 In-house 8-149 (152) alignment 
Range on Protein: 185-324
Range on HMM: 8-149/152.0
PFMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKY--RSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEE-ARLSGEKVIVHCHAGMSRSVTVV
||... ....|.  .|.... |.| ||. ....|... ..       ..|...|..| .  |. |.|.... |||. |. .|..|.|||.||..|. |.|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

LSYLMKyYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
. |||. .|...  |...|..|.... ||......| .||. |
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0046846 (Phosphotyrosine protein) phosphatases II 185-325 1.2e-31 105.1 In-house 12-173 (176) alignment 
Range on Protein: 185-325
Range on HMM: 12-173/176.0
PFMILSHLYLGCRE----------AASDIEALRESGISRVLNVTSEDS-----------KYRSMdSFTYYQIPVEDVHEVDMlQHLPEAFTFIEEARLSG
.  |. .|.||.|            |...| |.| ||. |.|.|.|              .... ...|...|..| .  |. ..|.|.. ||.||. .|
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpelekl.giqylhlpwpDhgvpdl.elllellefirealkeg

EKVIVHCHAGMSRSVTVVLSYLMKY-YGYTFNSAYDYVKQKKS-NISPNFSFIQQLVQFESSLR
..|.|||.||..|. |.|. ||... .|.. . |...|..... .. ........| .||  |.
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_MKPLT_pd Subfamily MKPLT 185-322 1.8e-29 96.3 In-house 21-158 (164) alignment 
Range on Protein: 185-322
Range on HMM: 21-158/164.0
PFMIL-SHLYLGCREAASDIEALRESGISRVLNVTSEDSKyRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLS
| ..|  .||||  . | . . |..  |  ..||. |  . .   |. | |. |||. .  . ..|  |  |. .|  || .|.|||  | ||| .| . 
psvvledtlylGnakhatnekvlkdlkithivnvsqekkd.afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
.|.|. |.|.. ||.|.|...| ..||  |..|| .|| 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 185-322 1.8e-29 96.3 In-house 21-158 (164) alignment 
Range on Protein: 185-322
Range on HMM: 21-158/164.0
PFMIL-SHLYLGCREAASDIEALRESGISRVLNVTSEDSKyRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLS
| ..|  .||||  . | . . |..  |  ..||. |  . .   |. | |. |||. .  . ..|  |  |. .|  || .|.|||  | ||| .| . 
psvvledtlylGnakhatnekvlkdlkithivnvsqekkd.afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
.|.|. |.|.. ||.|.|...| ..||  |..|| .|| 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
PTPc_motif_SM00404 186-322 8.1e-42 137.4 In-house 3-139 (140) alignment 
Range on Protein: 186-322
Range on HMM: 3-139/140.0
FMILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYL
  || |||||  ..|.. . | . ||. |.|||.| |. ... .|.. |||..| .. .....|... .|||.|. .|.||.||| ||.|||.|... ||
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

MKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
|.|.... ..||..||.....||||..|..||...| 
mryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_STYX_pd Subfamily STYX 186-322 2.6e-25 82.4 In-house 13-155 (166) alignment 
Range on Protein: 186-322
Range on HMM: 13-155/166.0
FMILSHLYLGCREAA--SDIEALRESGISRVLNVTS----EDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVT
  ||  |.||   ||  | .| |.. ||. .. .      .  |    |.| |  . | |    .....||.  .||...  .| ||.||  ||.||| .
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

VVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
.|..|.|. ||  . .|. ||....  |.||  |..|| ..|.
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
PTEN_1 187-327 5.8e-35 115.9 In-house 43-194 (196) alignment 
Range on Protein: 187-327
Range on HMM: 43-194/196.0
MILSHLYLGCREAA-SDIEALRESGISRVLNVTSEDSK----YR----SMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARL--SGEKVIVHCHAGMS
 |  .||.| .. . .| . | |.||  |.|...|.      |.        ..|...|.|| .  .. ... ..  ||| ...  .|..|.|||.||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLRSS
||.||| .|||.....|.. | ..|..| ....|| .. ..|......|...
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 187-324 1.7e-29 98.2 In-house 14-169 (174) alignment 
Range on Protein: 187-324
Range on HMM: 14-169/174.0
MILSHLYLGCREAAsDIEALRESGISRVLNVTSEDS--------------KYRSMDSFTYYQIPVEDVHEVDMLQhLPEAFTFIEEARLS--GEKVIVHC
.|...|..|.  .| ..| |.| ||. |.....|                .. .   ..|...|..| .. |. . | |.. |.|||...  | .|.|||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

HAGMSRSVTVVLSYLMKYYGY-TFNSAYDYVKQKK---SNISPNFSFIQQLVQFESSL
.|| .|. |.|. |||..... ..  |.|.|....   ... ...|....| .||. |
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 187-323 1.3e-26 89.0 In-house 41-240 (243) alignment 
Range on Protein: 187-323
Range on HMM: 41-240/243.0
MILSHLYLGCR--------EAASDIEALRESGISRVLNVTSED--------------------------------------------SKYRSMDSFTYYQ
... .|....          .||... | | ||. ....|...                                             .. .   . |..
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IPVED----VHEVDMLQHLPEAFTFIEE-----ARLSGEKVIVHCHAGMSRSVTVVLSYLMKYY-GYTFNSAYDYVKQKKSN-ISPNFSFIQQLVQFESS
.|. |     .  |.|..| |. .||||     |. ||..|.|||.|| .|. |... |||... |... .|.......... . ...|....| ...  
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 187-318 2.8e-23 77.6 In-house 10-147 (151) alignment 
Range on Protein: 187-318
Range on HMM: 10-147/151.0
MILSHLYLGCREAASDIEALRESGISRVLNVTSED-----SKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLS-GEKVIVHCHAGMSRSVTV
.. ..||..    | ..| |.| ||. ..|..||.      .|    ......||..| .. .. ......  |.|...   . .|.|||.||..|. |.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

VLSYLMKyYGYTFNSAYDYVKQKKS-NISPNFSFIQQLV
|. |||. .|.....|......|    . ||  |. || 
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_DSP12_pd Subfamily DSP12 188-324 1.4e-40 133.2 In-house 5-143 (155) alignment 
Range on Protein: 188-324
Range on HMM: 5-143/155.0
ILSHLYLGCREAASDIEALRESGISRVLNVTSEDS-KYRSMDSFTY-YQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYL
||  ||||  ||. . | |.| .|..|| |..|.  ...   . ..  .|.. |  |.|.|.||.||..|||||.  ...|.|||.||.|||||.|. ||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
||...  ...|.. ||.||..|.|| .|..||  || . 
mkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_DSP19_pd Subfamily DSP19 188-324 3.5e-38 125.3 In-house 15-150 (152) alignment 
Range on Protein: 188-324
Range on HMM: 15-150/152.0
ILSHLYLGCREAASDIEALRESGISRVLNVTSEDSKYrSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMK
.  .||||  ..|.| |.|.| .|  .|||. .  .    . ||| .|.. |. | |.|..|.||. |||||| .   |.|||.||.|||..||..||||
veprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
    ....|...|.... .|.||  ||.|| ..|..|
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 188-327 1.7e-36 119.5 In-house 10-147 (157) alignment 
Range on Protein: 188-327
Range on HMM: 10-147/157.0
ILSHLYLGcREAASDIEALRESGISRVLNVTSEDSKyRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMK
| ..|.|.   ||.. |.|.. .|. ..||| | .. ...... . ..|||| .|... .|. |.   |||.. .| |..||| ||.||| ...| ||||
itpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmk

YYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLRSS
|   . . || .||.... |.||  | .||...|. |. .
yeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
0043147 (Phosphotyrosine protein) phosphatases II 188-324 4e-34 113.2 In-house 22-160 (172) alignment 
Range on Protein: 188-324
Range on HMM: 22-160/172.0
ILSHLYLGCREAASDIEALRESGISRVLNVTSE--DSKYRSMDSFTYYQIPVEDVHEVdMLQHLPEAFTFIEE--ARLSGEKVIVHCHAGMSRSVTVVLS
.. .......  |.... |.| ||. ..|.|..  | .. .   ..|. .|..| .   .|..|.|.. ||.|  |. .|..|.|||.||..|..|.|. 
fiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaa

YLMKyYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSL
|||. .|...  |...|..|......|.|....| .||. |
ylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP15_pd Subfamily DSP15 188-323 8.1e-33 107.6 In-house 5-138 (151) alignment 
Range on Protein: 188-323
Range on HMM: 5-138/151.0
ILSHLYLGCREAASDIEALRESGISRVLNVTSedSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMK
.|  |||| .. ..| | |.|  |. .|.|    .. . .. ..|  |...|  .... ... |.  || ..|| .|.|.||| ||.|||||.|  ||| 
vlpglylgnfrdskdeelLkeknithilsvhd..nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

YYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
   . .. | . .|...|   ||| | .|| ..| .
vtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0042113 (Phosphotyrosine protein) phosphatases II 188-322 1.2e-25 85.8 In-house 50-240 (245) alignment 
Range on Protein: 188-322
Range on HMM: 50-240/245.0
ILSHLYLGCREAASDIE----ALRESGISRVLNVTSED---------------------------------------------SKYRSMDSFTYYQIPVE
|  .....   .....|     |.| ||. ....|.|.                                              .. |   ..|...|..
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DVHEVDMLQHLPEAFTFIEEARL--SGEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
| .. |.|..| ... |...|.   |...|.|||.|| .|. |... |||     |..|... .|........... ...|....| ... 
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0049772 (Phosphotyrosine protein) phosphatases II 189-324 8.1e-34 113.1 In-house 151-273 (314) alignment 
Range on Protein: 189-324
Range on HMM: 151-273/314.0
LSHLYlgCREAASDIEALResgisrvlNVTSEDSKYRSMDsFTYYQIPVEDvHEVDMLQHLPEAFTFIEEArLSGEKVIVHCHAGMSRSVT-VVLSYLMK
|. ..  .   |.|.| |.        ... .....  .  ..|..|||.| .... |....|.. |||||   |..|.|||.||..|. | ||. ||||
ldgng..neptaadlellk........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

YYGYTFNSAYDYVKQKKSnISPNFSFIQQLVQFESSL
..|.... |...|..| . |.||..||.|| |.|  |
llgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 190-322 1.4e-30 99.8 In-house 13-145 (148) alignment 
Range on Protein: 190-322
Range on HMM: 13-145/148.0
SHLYLGCREAASDIEALRESGISRVLNVTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYY
..|.|| .. |.|.|||.. |..|. | | |  .     .  |......|  . |. .  ... .|...|.  |..|.||.. |.|||  ..| .|... 
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

GYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
  . . |...||.|.  . ||  |..|| ..| 
rvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP3_pd Subfamily DSP3 190-325 4.4e-30 98.5 In-house 16-158 (162) alignment 
Range on Protein: 190-325
Range on HMM: 16-158/162.0
SHLYLGCREAASDIEALRESGISRVLNVTSE--------DSKYRSMdSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLS-GEKVIVHCHAGMSRSVTV
 .||.| ...|.| . |.. ||  ||| .          .. |. . ...|. ..|.|| |.|. ..  .|. ||.||  .   ||.|||..|.||| |.
pklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdl.eikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatl

VLSYLMKYYGYTFNSAYDYVKQKKsNISPNFSFIQQLVQFESSLR
|| ||| .   | ..|   |..|. .| ||  |..||......|.
vlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 190-325 6.5e-22 71.5 In-house 8-153 (154) alignment 
Range on Protein: 190-325
Range on HMM: 8-153/154.0
SHLYLGCREAASDIEALRESGISRVLNV-TSEDSKYRS-------MDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEAR--LSGEKVIVHCHAGMSRSVT
..||..  .|| .   |..  |  .||| .  .  .            . | .. . |  . |....|  || ||..|   .  .||.||...|.||| .
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
...||||.    ..  |.  .|. .  |.||  |..|| .||  |.
llisylmdklkislslalellkdsryiikPnqGflkqleifekell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 191-325 1.8e-26 86.0 In-house 5-142 (145) alignment 
Range on Protein: 191-325
Range on HMM: 5-142/145.0
HLYLGCREAASDIEALRESGISRVLNVTSEDS---KYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMK
.|| |    |.|. .|.| ||||..|... ..   .    .|..   |  ||..  |. ||. |   ||.  .  |  |.||| ||.|||||| ...|||
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

YYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
| . |.  |   |. ..    ||  |...|...|  |.
ycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
DSPc Dual specificity phosphatase, catalytic domain 192-322 4.1e-40 131.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 192-322
Range on HMM: 1-132/133.0
LYLGCREAASdIEALRESGISRVLNVTSEDSK--YRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYY
||||  ..||  . | . ||. |.|||.| ..   ... ...| .||||| .| .. ..|.|| .|||.|. .|.||.||| ||.||| |... ||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
... |.||..||...|.||||..|..||...|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 192-322 4.1e-40 131.7 In-house 1-132 (133) alignment 
Range on Protein: 192-322
Range on HMM: 1-132/133.0
LYLGCREAASdIEALRESGISRVLNVTSEDSK--YRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYY
||||  ..||  . | . ||. |.|||.| ..   ... ...| .||||| .| .. ..|.|| .|||.|. .|.||.||| ||.||| |... ||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
... |.||..||...|.||||..|..||...|.
nlslneAyefvkerrskispnagflrqLleyer
0051429 (Phosphotyrosine protein) phosphatases II 193-321 8.7e-20 66.9 In-house 25-221 (272) alignment 
Range on Protein: 193-321
Range on HMM: 25-221/272.0
YLGCRE---AASDIEALRESGISRVLNVTSED----SK-YRSMDSFTYYQIPVEDVHEVDML--------------------------------------
|.. .     | |...|.| ||. .....||.     | .|    ..|...|..| .. ..|                                      
yrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

-------------QHLPEAFTFIEEarlsGEKVIVHCHAGMSRSVTVVLSYLMKyYGYT--------------FNSAYDYVKQKKSNISPNFSFIQQLVQ
             . | |.. .. .    |..|.|||.||..|. |||. .|.  .| .                 |.......  .. ..  ....| .
lhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

FE
..
al
0040439 (Phosphotyrosine protein) phosphatases II 200-323 2.7e-26 88.1 In-house 68-244 (249) alignment 
Range on Protein: 200-323
Range on HMM: 68-244/249.0
ASDIEALRESGISRVLNVTSEDSKY------------------------------------------RSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIE
..... |.| ||. ....||.. .                                              .|.|...|.. | .. .  ....... |||
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

EARL------SGEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
..|       .|..|.|||.||..|. |... |||     |..|... .|........... .|......| ...  
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_DSP23_pd Subfamily DSP23 203-303 1.2e-08 29.7 In-house 24-124 (148) alignment 
Range on Protein: 203-303
Range on HMM: 24-124/148.0
IEALRESGISRVLNVTSED-SKYRSMDSFTYYQIPVEDVHEVdMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVK
.. | . |.  .. .| |   .  .. . |.... ..| |    |. . |    .|||   .| | |||  |. |. |..  ||.|  . .   |   |.
yrylldlgvrylvslteegrphveatpnltlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevr

QK
..
rl
0045450 (Phosphotyrosine protein) phosphatases II 204-323 4.5e-26 87.7 In-house 125-302 (307) alignment 
Range on Protein: 204-323
Range on HMM: 125-302/307.0
EALRESGISRVLNVTSEDSKYR---------------------------SMDSFTYYQIPVEDV-----------------HEVDMLQHLPEAFTFIEEA
. |.| |.. ....|... . |                            .|..|.....|.|                   . .  ... |.. ||||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RL------SGEKVIVHCHAGMSRSVTVVLSYLMKYYG--------YTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
|       .|..|.|||.||..|. |... |||....        ... .|........... .|......| ...  
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 204-321 2e-23 78.6 In-house 104-272 (317) alignment 
Range on Protein: 204-321
Range on HMM: 104-272/317.0
EALRESGISRVLNVTSEDSKYR--------------------------SMDSFTYYQIPVEDV----------------HEVDMLQHLPEAFTFIEEARL
. . | |.. ....|... . |                           ....|.....|||                  . .  ... . . |.|..| 
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

S----GEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFE
.    |..|.|||.|| .|. |... |||     |..|... .|........... ........| ...
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
0039614 (Phosphotyrosine protein) phosphatases II 205-325 3.2e-22 74.8 In-house 120-289 (297) alignment 
Range on Protein: 205-325
Range on HMM: 120-289/297.0
ALRESGISRVLNVTSED------------------------SKYRSMDSFTYYQIPV-----------------EDVHEVDMLQHLPEAFTFIEEARL--
 ..| |.. ....|...                         |.   | .|.....|                  | .  . |..| |.. ...||.   
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-SGEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESSLR
 .|..|.|||.|| .|. |... |||     |..|... .|........... ...|....| ...  |.
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0046845 (Phosphotyrosine protein) phosphatases II 207-317 7.8e-12 40.6 In-house 145-266 (284) alignment 
Range on Protein: 207-317
Range on HMM: 145-266/284.0
RESGISRVLNVTSE--DSKYRSMDSFTYYQIPVEDVHE-VDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYY--------GYTFNS
... . |.| .| .  ....| .  | | ..|  .| . .. |... ..   . |.. .|....|||.||..|. |... .|....        |... .
kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvle

AYDYVKQKKSNISPNFSFIQQL
|. ...... .   ... .. .
avkrlreqRpgmvqtleqyrfv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 207-278 9.1e-06 20.0 In-house 158-232 (297) alignment 
Range on Protein: 207-278
Range on HMM: 158-232/297.0
RESGISRVLNVTSEDSKY-RSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEK--VIVHCHAGMSRSV
|| .| | |.|| ...|  | .. . . . |...|.. |  . | .  . ...   . ..  ..||| ||. |  
reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg
0036941 (Phosphotyrosine protein) phosphatases II 208-322 1.4e-18 62.7 In-house 100-274 (297) alignment 
Range on Protein: 208-322
Range on HMM: 100-274/297.0
ESGISRVLNVTSEDSKYR------------------------------SMDSFTYYQIPVED----------------VHEVDMLQHLPEAFTFIEEARL
| ... ....|..... |                                |..|.... |.|                  . .. ..  . . |||..| 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------SGEKVIVHCHAGMSRSVTVVLSYLM--------KYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFES
      ||..|.|||.|| .|| |... .||        |..|... .|. ...... .. ..... ..| ... 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_Laforin_pd Subfamily Laforin 208-301 7e-10 32.1 In-house 54-148 (183) alignment 
Range on Protein: 208-301
Range on HMM: 54-148/183.0
ESGISRVLN-VTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVK
 ||| |  . .     |    . ..|  .|.||.     .. ||.|  ..      | .| ||| ||. || ..|  .|.   |....    .. 
ssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfll
0043336 (Phosphotyrosine protein) phosphatases II 209-321 9.9e-18 60.0 In-house 156-273 (278) alignment 
Range on Protein: 209-321
Range on HMM: 156-273/278.0
SGISRVLNVTS-EDSKYRSMDSFTYYQIPVEDVHEvDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQ
  . |.|.||   |...|    . |. .|  .| | .. ..|    ...|  . |...|.|||.|| .|. |... ||.     |..|... .|......
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelre

KKSNISPNFSFIQQLVQFE
.. .. ...|....| ...
qRpgavqtpsqyrflyeal
0038934 (Phosphotyrosine protein) phosphatases II 210-328 9.7e-23 76.2 In-house 56-180 (194) alignment 
Range on Protein: 210-328
Range on HMM: 56-180/194.0
GISRVLNVTSEDSKYrSMDS-----FTYYQIPVEDVHEVDMLQHLPEAFTFIEE--ARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQ
..  |...| ..  | . .      ..|...|..| ..|  |. | . . ...|  .. .|..| |||.||..|. |.| .||....|.. . |......
klglvidltnteryY.dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

KKSNISPNFSFIQQLVQFESSLRSSP
|. .. || .....|... . ||...
kRpgaipnqdyleallkrykelrkav
0051299 (Phosphotyrosine protein) phosphatases II 210-315 1.7e-12 42.9 In-house 162-276 (288) alignment 
Range on Protein: 210-315
Range on HMM: 162-276/288.0
GISRVLNVTSEDSKYRSMDSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLS----GEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYV
 . |.| ||  |    .  |.|.... . .  . .. ... . ..|....| .    |  |.|||.|| .|. |... .|.     | .| .. .|. ..
ytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

KQKKSNISPNFSFIQ
.... .. .... ..
reqRpgmvqtpeqyr
0050432 (Phosphotyrosine protein) phosphatases II 210-313 3.1e-11 38.6 In-house 181-287 (308) alignment 
Range on Protein: 210-313
Range on HMM: 181-287/308.0
GISRVLNVTS-EDSKYRSMDSFTYYQIPvedvhEVDMLQHLPEAFTFIEEARLS--GEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVK
 . |.| .|  .|...| .  | |   |     . .  ... . ..|.|..| |  |....|||.|| .|. |... .|.     | .| .. .|. ...
ytvrtleltnlgdgesrtvthfhytnWp.....dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklR

QKKSNISPNFSF
... .  .... 
eqRpgmvqtpeq
0047943 (Phosphotyrosine protein) phosphatases II 211-319 4e-15 51.5 In-house 151-266 (273) alignment 
Range on Protein: 211-319
Range on HMM: 151-266/273.0
ISRVLNVTS-EDSKYRSMDSFTYYQIPVEDVH-EVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLM-----KYYGYTFNSAYDYVKQK
. |.| .|. .....| .  | |. .|  .|   ...| .. |.   . ||  |...|.|||.|| .|. |... .|.     |..| .. .|. .....
tvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

KSNISPNFSFIQQLVQ
. .. ........| .
Rpgmvqtpeqyrflye
subfamily_PTEN_pd Subfamily PTEN 212-305 7.4e-06 21.1 In-house 62-157 (184) alignment 
Range on Protein: 212-305
Range on HMM: 62-157/184.0
SRVLNVTSEDsKYRSMDS-FTYYQIPVEDvHEVDMLQHLPEAFTFIEEA-RLS-GEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFN-SAYDYVKQKKS
 ...|..||  || | .      ..|..| |.   |. | |. . ||.    .  . |.|||.||  |. ... .||.|.  .. . .| .. .....
ykiynlrser.kydskkfdgrvavypfdD.hnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_MSG5_pd Subfamily MSG5 213-325 5.3e-22 71.7 In-house 50-161 (165) alignment 
Range on Protein: 213-325
Range on HMM: 50-161/165.0
RVLNVTSEDSKYRS-MDSFTYYQIpvEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPNF
 |.||. | .. .  . .  || |  |  |.  . . |..  . |  |.  ..|..|||  |.||| .....|.||||. ... ||| .| .  .|||..
lvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsi

SFIQQLVQFESSLR
 .| ||...|  | 
glifqlmewevals
subfamily_RNGTT_pd Subfamily RNGTT 218-305 1.7e-06 21.8 In-house 74-155 (189) alignment 
Range on Protein: 218-305
Range on HMM: 74-155/189.0
TSEDSKYRSMDSFTYYQIPveDVHEVDMLQHLPEAFTFieeaRLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQKKS
..|. ||  ..  .. . |  .  .|. ...| | |      . . | ..|||. |  |.  .. |||..   .  ..| .  .. . 
ekegikyvklqcagkgeaP..eaeqvkefiklveeffk....knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
subfamily_PTPMT1_pd Subfamily PTPMT1 224-324 4.2e-19 63.6 In-house 69-168 (171) alignment 
Range on Protein: 224-324
Range on HMM: 69-168/171.0
YRSMdSFTYYQIPVEDVHEVDMLQHLPEAFTFIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
....   ...|... |. |   |..| ..  |||. . .|..| |||.|| .|| |.| .|||| .  . ..| ...|.|.. |  .    ..| ..|..
wkkl.gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek

L
|
l
subfamily_PTPDC1_pd Subfamily PTPDC1 230-323 1.9e-08 29.0 In-house 83-174 (182) alignment 
Range on Protein: 230-323
Range on HMM: 83-174/182.0
FTYYQIPVEDVHeVDMLQHLPEAFTFIEEARLSGeKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPNFSFIQQLVQFESS
 ..|... .|   |  |... .    .. |   | || ||||||. |   .. .||.    .| . | . |..|...     . .. ...|.  
iyvynfgwkDyg.vasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalf
PTPc_DSPc_SM00012 240-287 1.6e-06 23.6 In-house 20-63 (105) alignment 
Range on Protein: 240-287
Range on HMM: 20-63/105.0
VHEVDMLQHLPEAFTFIEEarlsGEKVIVHCHAGMSRSVTVVLSYLMK
 . ...|... .  . .|.    .. |.|||.|| .|. |.|. ... 
dsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldill
0048567 (Phosphotyrosine protein) phosphatases II 252-310 3.5e-10 34.4 In-house 63-124 (157) alignment 
Range on Protein: 252-310
Range on HMM: 63-124/157.0
AFTFIEEARLSGEKVIVHCHAGM---SRSVTVVLSYLMKYYGYTFNSAYDYVKQKKSNISPN
.  |..  .| | ...|||.||.   .|..|.. .||....|.| . |......   .. | 
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf
subfamily_CDC14_pd Subfamily CDC14 255-301 7.4e-07 23.3 In-house 255-301 (328) alignment 
Range on Protein: 255-301
Range on HMM: 255-301/328.0
FIEEARLSGEKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDYVK
|.| |  .  ...|||.||. |  |.. .|||| |..| . |  ...
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 264-299 2.8e-07 23.3 In-house 67-102 (128) alignment 
Range on Protein: 264-299
Range on HMM: 67-102/128.0
EKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDY
  . |||  |  |.  |. || ||| || .. | ..
lvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 264-299 2.8e-07 23.3 In-house 66-101 (128) alignment 
Range on Protein: 264-299
Range on HMM: 66-101/128.0
EKVIVHCHAGMSRSVTVVLSYLMKYYGYTFNSAYDY
  . |||  |  |.  |. || ||| || .. | ..
lvlyvhcecgcdrtgevlasyvmkykgydlkkalew