Gene DSP8 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP011_AA protein Get Run
AqueP011_AA_187-322 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 24-120 3.6e-10 32.4 Pfam-A 12-103 (113) alignment 
Range on Protein: 24-120
Range on HMM: 12-103/113.0
EHYLVIDTRPLEDYERGHIATAVSYPHDTAassrSEEEREASLVAFARDYSSQFYRPENPNPLVLYGdrAESELRHTHWLADKLTLLKN-QRSRVSVY
|.....|.|. |.|..|||  ||. |.|..     ... . .   .|.. ...  . .. .. |.|.  . .. . ... . .  .||.    .|.|.
ekvvllDvRspeeyakghIpgAvnvpldsl....yprrdlffkdklaeeleesgkkldkdktvvvyc..rsgnrsggaaalllalilkelgyknvyvL
0049772 (Phosphotyrosine protein) phosphatases II 135-328 7.2e-18 60.8 In-house 93-276 (314) alignment 
Range on Protein: 135-328
Range on HMM: 93-276/314.0
SEETFDPFEEFCLTVIDKVKEI--WLLDCTYDSF------ASE------------YPFLCGRVrfeemfPLPHQITKNVFMgsrvvpmsshalskmgmsh
.|.|.. |.|...  ... . .  . |.. .         |.|            .. |.|.       ..|.  .   .                    
leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......neptaadlellk...................

viiSEHQDIDMEELKNVHVLKCPVKDkNDENMLPCWEASCSFIDKAvSENGRVLVF-VHGRSRSAS-VILAYLMKTLEMNFESSWTHLRSKCWhlIDKSL
   .|. | .  |  ....| .|| | .... |  ... . ||..| ...|.|||   .|..|... |..||||| | ...|  . ..|.|    |  . 
...eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp..inpnp

VFEEQLVQWYRELHCL
.| ||| |.. .|..|
gfieqleqyefileal
subfamily_DSP8_pd Subfamily DSP8 137-329 5.6e-73 237.7 In-house 2-158 (159) alignment 
Range on Protein: 137-329
Range on HMM: 2-158/159.0
ETFDPfeefCLTVIDkVKeiwlldctydsfaseypflcgrvrfeemfplPHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQDIDMEELKNVHVLKC
|...|    ||.|.| |.                               |..|.||...||.....|...|||.|.|.|..........||||....|..
elsqP....CLsvad.vg...............................ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrv

PVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVILAYLMKTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYRELHCLT
|||||.||..||....|..|||||.||||||||.|. |.||||.|..||.||||||...........|. ..|...|.|..||.....||..||
PvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptispnlnflgqLleyekelkllt
0041856 (Phosphotyrosine protein) phosphatases II 176-323 1e-15 53.3 In-house 17-170 (182) alignment 
Range on Protein: 176-323
Range on HMM: 17-170/182.0
RvrfeemfpLPHQITKNVFMGSRVV--------------PMSSHALSKMGMSHVII--SEHQDIDMEELKNVHVLKCPVKDKNDENmlpcWEASCSFIDK
|         ...|. |...||.                ..  . | ..| ....   .|. . . .|  ....|. |. | .  .    ..  ..||..
r........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfiee

AVSENGRVLVF-VHGRSRSASVILAYLMKTLEMNFESSWTHLRSKCWH-LIDKSLVFEEQLVQWYR
. .|.|.|||   .|..|......|||||.|....|. . ..||. ..  |  .  | .||. ...
vleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
0046846 (Phosphotyrosine protein) phosphatases II 178-325 4.8e-14 48.0 In-house 4-172 (176) alignment 
Range on Protein: 178-325
Range on HMM: 4-172/176.0
RFEEMFPLPHQITKNVFMGSRV----------VPMSSHALSKMGMSHVIIS--E--------HQDIDMEELKNVHVLKCPVKDKNDENMlPCWEASCSFI
|.   .. ...|. |...|||           ..   . | ..| ..|.    |        ... . .|  ....| .|. | .  ..   ..  . ||
rllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefi

DKAVSENGRVLVF-VHGRSRSASVILAYLMKT-LEMNFESSWTHLRSKCWHLIDKSLVFEEQLVQWYREL
..|..|.|.|||  ..|..|.. ...|||...   .. |    ..|.. .. .  .  . ..| .....|
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP1_pd Subfamily DSP1 184-326 4.4e-21 69.7 In-house 17-157 (163) alignment 
Range on Protein: 184-326
Range on HMM: 17-157/163.0
PLPhQITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQdIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVIL
|   .|.  ...||. |    . |...|.....   .. .|    .  .  | ...|......   .|    |||.. ..||.||.  . | |||....|
Pve.kildfLylGsetvasnleiLkslgitailnvske.ldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYLMKTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYRELH
|||||| ....|  ..  ...   .|   . |  ||... ..| 
aylmktkrvsleeafdfvkqrR.siisPnagFvlqLlnyekkll
PTEN_1 184-326 1.4e-14 49.4 In-house 39-192 (196) alignment 
Range on Protein: 184-326
Range on HMM: 39-192/196.0
PLPHQITKNVFMGSRVVP-MSSHALSKMGMSHVIISEHQDID--------MEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSEN--GRVLVF-V
||...| .....||.  . .  . | ..|  .|.  .. . .        ... ..| .|..|..| .  ..   ... .|||. . | .  . |||.  
pllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCk

HGRSRSASVILAYLMKTLEMNFESSWTHLRSKCWHLIDKsLVFEEQLVQWYRELH
.|..||. |. ||||..  ....  . ..|.| ..       . |.|.. ..||.
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn.spsqerlleyfaell
0043147 (Phosphotyrosine protein) phosphatases II 184-308 7.2e-12 40.8 In-house 17-144 (172) alignment 
Range on Protein: 184-308
Range on HMM: 17-144/172.0
PLPHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEH--QDIDMEELKNVHVLKCPVKDKNDEnMLPCWEASCSFIDK--AVSENGRVLVF-VHGRSRSA
  |...  . ..... ...  . | ..| .|..       | . .|  ....| .|. | .   .|  ..  ..|||.  |.|..|.|||  ..| .|..
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg

SVILAYLMKtLEMNFESSWTHLRSKCWHLI
 ...||||. | ...|    ..|.| .. .
tlvaaylml.lglsleeavalvrekRpgav
0044763 (Phosphotyrosine protein) phosphatases II 185-326 2.8e-19 64.9 In-house 22-171 (178) alignment 
Range on Protein: 185-326
Range on HMM: 22-171/178.0
LPHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQDI------DMEELKN--VHVLKCPVKDKNDENMLPCWEASCSFIDKAV-SENGRVLVF-VHGR
 ...|. ....||   ..    | ..| .|..   . .       | . ...  ...|..|. | .. ..|  ... . ||..|. ...|.|||   .|.
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSASVILAYLMKTLEMNFESSWTHLRSKCWhlIDKSLVFEEQLVQWYRELH
.||.....|||||.| ...|. . ..|.. .  |  .  . .|| .....|.
gRsgtlvaaylmkklglsleeaielvrerRp..ivpnpgqlrqLyefelrll
subfamily_DSP6_pd Subfamily DSP6 185-326 2.9e-19 63.1 In-house 13-155 (158) alignment 
Range on Protein: 185-326
Range on HMM: 13-155/158.0
LPHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEH-QDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVIL
.| .|......||.     . .|.|.....|.   .  .   || .... |. |..|.  .|.   .  . .|||.| |..  |||  . | |||  |.|
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYLMKTLEMNFESSWTHLRSKCWHlIDKSLVFEEQLVQWYRELH
|||||.|.. .....  ....  . |   . | .||... |.|.
aylmkklalslndaydlvkkrksn.isPnfnfmgqlldferslr
0048076 (Phosphotyrosine protein) phosphatases II 185-325 3.9e-19 64.2 In-house 3-142 (145) alignment 
Range on Protein: 185-325
Range on HMM: 3-142/145.0
LPHQITKNVFMGSRVVPMSSHALSKMGMSHVIISeHQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILA
 |..|. ... ||  ....   | ..|  .|.     ... .| .....| .|. | .  ..|  ... . ||..|..|.|.|||.  .|..|......|
wpseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKTLEMNFESSWTHLRSKCWHlIDKSLVFEEQLVQWYREL
|||..| ...|. . ..||. .. .  .  . ..| ....||
ylmlllgvsleealelvrsqrpg.avpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 185-322 1.6e-18 62.3 In-house 3-141 (144) alignment 
Range on Protein: 185-322
Range on HMM: 3-141/144.0
LPHQITKNVFMGSRVVPMSSHALSKMGMSHVI-ISEHQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVIL
 |..|. ....||  ....   | |.| ..|| ..|. . . .|  ....|..|. | .  ..|  ... . ||..|..|.|.|||   .|..|......
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMKTLEMNFESSWTHLRSKCWHLIdKSLVFEEQLVQWY
|||||.| ...|. . ..||. .. .  .  . ..| ...
aylmkklglsleealalvrsrrpgav.pnpgqlrfLleye
subfamily_LRR-DSP_pd Subfamily LRR-DSP 185-327 4.6e-12 39.6 In-house 119-260 (263) alignment 
Range on Protein: 185-327
Range on HMM: 119-260/263.0
LPHQITKNVFMGSRVVPMSSHALSKMGMSHV--IISEHQDIDMEELKNVHVLkcPVKDKNDENMLPCWEASCSFIDKAVsENGRVLVFV-HGRSRSASVI
.| .| ...|.|..   .    | ..|..|.   ... . .  . .| . .    ..| .. ..   .|   .||..   ..| |||    | |||....
vPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsid..diedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsstlv

LAYLMKTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYRELHC
..||||  ...|. .     .|    |     | .|| .. ..| |
isylmkkqrlkfkealdlvikkr.priqPnpGfkdqlkkyekklfc
PTPc_motif_SM00404 186-323 2.5e-22 74.3 In-house 2-139 (140) alignment 
Range on Protein: 186-323
Range on HMM: 2-139/140.0
PHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEH-QDIDmEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILA
| .|......||    ...  |.|.|..|||     .... .| .....|..|..|.. ..... ...  .||..| ...|.|||.  .| ||||..|.|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMKTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYR
|||.. ... ....  ....    |...| | .||.....
YlmryrqlslaeayefvkerR.piispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 186-320 8.5e-18 58.3 In-house 19-152 (169) alignment 
Range on Protein: 186-320
Range on HMM: 19-152/169.0
PHQITKNVFMGSRVVPMSSHALSKMGMSHVIiSEHQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFV-HGRSRSASVILAY
. .| . |..||       . |...|.....    ..||    .... |.  | |......|. |. . .||.|| ... .|||    | |||||...||
askifdhvylGsewnasnleelkengveyil.nvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMKTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLVQ
 ||. ....|.........  ..|     | .|| .
amkeyglsleealeyvkerr.svikPnkgflkqlee
0045098 (Phosphotyrosine protein) phosphatases II 186-325 5.6e-10 34.5 In-house 22-271 (278) alignment 
Range on Protein: 186-325
Range on HMM: 22-271/278.0
PHQITKNVFMGSRV-----------------------------------------VPMSSHALSKMGMSHVIISE-------------------------
| .|| ... |..                                          |    . | ..| ....                            
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

--------------------------HQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVS--------------ENGRVLVF-VHGRSRSA
                          ..|.   ... .| |  |  .  ....|  .   . ||..|..              ..|.|||   .| .|..
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

SVILAYLMKTL---EMNFESSWTHLRSKCWHLIDKSLVFEEQLVQWYREL
 ...||||..|    .....  ..|||. ..|.  .| . ..| .. .||
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0049260 (Phosphotyrosine protein) phosphatases II 186-309 5.8e-10 34.5 In-house 8-134 (152) alignment 
Range on Protein: 186-309
Range on HMM: 8-134/152.0
PHQITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQDIDME--ELKNVHVLKCPVKDKNDENMLPCWEASCSFIDK-AVSENGRVLVF-VHGRSRSASVI
|.... . ..|.  ..   . | ..| ....     . . .  . .  ..| .|. | .  ..  . .  . ||.| | ...|.|||  ..| .|.. ..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

LAYLMKtLEMNFESSWTHLRSKCWHLID
.||||. | ...|    ..|.| .. . 
aaylml.lgvsleeavalvrekRpgavp
subfamily_DSP14_pd Subfamily DSP14 187-323 1.2e-20 68.0 In-house 8-142 (157) alignment 
Range on Protein: 187-323
Range on HMM: 8-142/157.0
HQITKNVFMGsRVVPMSSHALSKMGMSHVIISEHQDIDmEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYL
 |||.. |..  |. .| ..|.| .....|    .  . ..||.....| ||.|...... . ..  .  |...  ..|..||. | |.|||||. ||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKTLEMNFESSWTHLRSKcWHLIDKSLVFEEQLVQWYR
||. ... . ......|.   .|   . | .||... .
mkyeklsLreayklvksa.RpiirPNvGFwkqlidyEk
subfamily_DSP19_pd Subfamily DSP19 188-319 1.2e-19 65.2 In-house 14-144 (152) alignment 
Range on Protein: 188-319
Range on HMM: 14-144/152.0
QITKNVFMGSRVVPMSSHALSKMGMSHVIiSEHQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVILAYLM
........||  | .....|.. .. |.. .   ...    |....|. .. |......|  ....  ||..| |..|.|||  . |.||||||..||||
eveprlylgsqdvaadkeilkekkitHil.nvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KTLEMNFESSWTHLRSKCwHLIDKSLVFEEQLV
|. |...|.. . .|..    |.    | .|| 
kkeelsleealelvrear.pcikPneGFikqLk
subfamily_DSP12_pd Subfamily DSP12 188-323 6.4e-19 62.9 In-house 4-141 (155) alignment 
Range on Protein: 188-323
Range on HMM: 4-141/155.0
QITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQDIDMEELKN--VHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFV-HGRSRSASVILAY
.|......|.    .. . |......||.   ..... ..||.  |. .. .. |...|..|   .  ..||..|..|.| |||    | |||.....||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMKTLEMNFESSWTHLRSKcWHLIDKSLVFEEQLVQWYR
|||. ....|.    ...|  . |     | |||  ...
lmkkeklslekAlklvkek.kpeiepNegFleQLklfek
subfamily_DSP3_pd Subfamily DSP3 188-304 7.5e-17 55.4 In-house 13-138 (162) alignment 
Range on Protein: 188-304
Range on HMM: 13-138/162.0
QITKNVFMGSRVVPMSSHALSKMGMSHVIISEHQ-----DIDMEELK--NVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSE-NGRVLVF-VHGRSRSA
........| . | .  . | |.|. ||. . .      | . |  |  ... |  .|.|.   ..   .| . .|||.|.|. .|.|||  | | ||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

SVILAYLMKTLEMNFESSWTHLRSKC
 ..||||| . .|.  .  .. |.| 
tlvlayLmirrkmtlveairtvrkkR
subfamily_DSP10_pd Subfamily DSP10 188-326 1.8e-16 54.4 In-house 16-154 (159) alignment 
Range on Protein: 188-326
Range on HMM: 16-154/159.0
QITKNVFMGSRVVPMSSHALSKMGMSHVI-ISEHQDIDMEElKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVILAYL
|.   .|.|| .   . .|| ......|. .  .    .|| ....  . ||.|.. .|.   .|..  ||..| ... ||||  . | ||||.|..|||
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYl

MKTLEMNFESSWTHLRsKCWHLIDKSLVFEEQLVQWYRELH
|| |..... .. . . ..   |   | |  ||... .||.
mkhlnlslndaykfvk.ekrpiisPnLnfmGqLlefekeln
subfamily_DSP15_pd Subfamily DSP15 188-320 3.1e-13 44.1 In-house 4-134 (151) alignment 
Range on Protein: 188-320
Range on HMM: 4-134/151.0
QITKNVFMGSRVVPMSSHALSKMGMSHVIiSEHqDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLM
.. .....| . .   .. |..  ..|.. | | |   . ||... .  ...|  . ..    . | .|| |. .... |||  . | |||. .. ||||
kvlpglylgnfrdskdeelLkeknithil.svh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KTLEMNFESSWTHLRSkCWHLIDKSLVFEEQLVQ
  .|.|.. . . ..  .  . .  . |..|| .
tvtelnwrdalevika.aRsvanPnfGfkrqlke
0051082 (Phosphotyrosine protein) phosphatases II 188-320 2.2e-10 35.8 In-house 10-148 (151) alignment 
Range on Protein: 188-320
Range on HMM: 10-148/151.0
QITKNVFMGSRVVPMSSHALSKMGMSHVIISEH-----QDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSE-NGRVLVF-VHGRSRSASV
..| ... ..   .     | ..| ....          . .  .  ...|| .|. |  | ..  ...|  .|.... .  || |||   .|..|.. .
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

ILAYLMKtLEMNFESSWTHLRSKCWHLIDKSLVFEEQLVQ
...|||. | ...|. . ..|.| ....  .  |  || .
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_STYX_pd Subfamily STYX 189-321 1.5e-12 40.9 In-house 15-153 (166) alignment 
Range on Protein: 189-321
Range on HMM: 15-153/166.0
ITKNVFMGSRVVPMSSH--ALSKMGMSHVIISeHQDIDMEELK-----NVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFV-HGRSRSASV
|   .|.|     | |.   | | |..|..    |.|. . .|     . . |   | |.  ||..       .|||..... |.|||    | ||||..
ilpglflgpysaamksklevlkkhgithivci.rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

ILAYLMKTLEMNFESSWTHLRSKCWhLIDKSLVFEEQLVQW
..||.|.|  ... ....... . .  |.    | .|| ..
viayimetyglkyreafayvqerrf.cinpnegfvsqlkey
0036282 (Phosphotyrosine protein) phosphatases II 189-304 3.8e-09 32.0 In-house 15-146 (174) alignment 
Range on Protein: 189-304
Range on HMM: 15-146/174.0
ITKNVFMGSRVVPmSSHALSKMGMSHVIISEHQD--------------IDMEELKNVHVLKCPVKDKNDENMLPcWEASCSFIDKAVSENGRVLVFV---
||.... |.   .   . | . | ..|.   .                 . .|  ....|..|. | .  ..   ..  ..|...|.||..   | |   
itprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

HGRSRSASVILAYLMKTLEM-NFESSWTHLRSKC
.|..|.. ...||||... . ...  . ..|.. 
aGvgRtGtlvaaylmlrglleslvdaldlvrelR
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 192-321 1.8e-20 67.0 In-house 14-143 (148) alignment 
Range on Protein: 192-321
Range on HMM: 14-143/148.0
NVFMGSRVVPMSSHALSKMGMSHVIISEHQDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVILAYLMKTLE
 .|.||.   ..  || ..|.....  ...   . . . .. |.....||..|..   .|   .|..||..| .|||| .. |.|||. . |..|... .
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MNFESSWTHLRSKCWHlIDKSLVFEEQLVQW
.  .      .||  . .|. | | .|| ..
vslkealalvkskrry.vdpnlgfLkqLael
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 193-303 1.2e-06 21.7 In-house 6-120 (145) alignment 
Range on Protein: 193-303
Range on HMM: 6-120/145.0
VFMGSRVVPMSSHALSKMGMSHVII-SEHQDIDMEELK--NVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLMKT
...|| . . .. .| ..|.| ..  .  . .  .|||  ....|    .| .  ..   ..    ||||   |   |.|  . | ||| .| .|.||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LEMNFESSWTHLRSK
 .| .  .   .||.
cnmtlseaarqvrsn
DSPc Dual specificity phosphatase, catalytic domain 194-323 6.4e-20 66.4 Pfam-A 2-132 (133) alignment 
Range on Protein: 194-323
Range on HMM: 2-132/133.0
FMGSRVVPMsSHALSKMGMSHVI-ISEHQDI-DMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLMKTLE
..||    .    |.|.|...|| .... .   . . .. . |..||.|...... .  |.. .||.|| .....|||   .| ||||..|.|||||| .
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYR
.. .. . .....    | ..  |  ||....|
lslneAyefvkerr.skispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 194-323 6.4e-20 66.4 In-house 2-132 (133) alignment 
Range on Protein: 194-323
Range on HMM: 2-132/133.0
FMGSRVVPMsSHALSKMGMSHVI-ISEHQDI-DMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLMKTLE
..||    .    |.|.|...|| .... .   . . .. . |..||.|...... .  |.. .||.|| .....|||   .| ||||..|.|||||| .
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MNFESSWTHLRSKCwHLIDKSLVFEEQLVQWYR
.. .. . .....    | ..  |  ||....|
lslneAyefvkerr.skispnagflrqLleyer
0037934 (Phosphotyrosine protein) phosphatases II 205-324 9e-12 40.5 In-house 110-240 (243) alignment 
Range on Protein: 205-324
Range on HMM: 110-240/243.0
HALSKMGMSHVIISEHQDIDMEELKNVHVLKCPVKD----KNDENMLPCWEASCSFIDK-----AVSENGRVLVF-VHGRSRSASVILAYLMKTL-EMNF
    .  . ...  |. |.| ... ..|..  |. |     . |..|  ... ..||..     | ...|.|||  ..|..|.. .|.||||..| ....
eehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdl

ESSWTHLRSKCWHLIDKSLVFEEQLVQWYRE
|. . .||.. ....  .. . ..| ....|
eeavkllreqRpgkavqtpsqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 213-325 1.6e-19 63.7 In-house 40-153 (157) alignment 
Range on Protein: 213-325
Range on HMM: 40-153/157.0
SHVIISEHQDIDMEELKN-VHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFV-HGRSRSASVILAYLMKTLEMNFESSWTHLRsKCWHLIDK
.|| .|   |  .. ... ...|...|.|.|. ..|.  .  ..||.| . |.  ||||  .| ||||.||.||||   ..........|. || . .  
ahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylk.kCkenvkP

SLVFEEQLVQWYREL
   | ||| .| ..|
nrafveqlseWekql
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 219-325 6e-11 35.9 In-house 46-152 (154) alignment 
Range on Protein: 219-325
Range on HMM: 46-152/154.0
EHQDIDmeELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAV--SENGRVLVFV-HGRSRSASVILAYLMKTLEMNFESSWTHLRSkCWHLIDKSLVFE
|  ||.  .   .. |.  . |. . ...   . .  |||.|.   ||..|||   .| ||||.....|||. |....  .   |.. . . |     | 
ensdin..dgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkd.sryiikPnqGfl

EQLVQWYREL
.|| .. .||
kqleifekel
0042113 (Phosphotyrosine protein) phosphatases II 221-308 3.7e-10 35.1 In-house 131-226 (245) alignment 
Range on Protein: 221-308
Range on HMM: 131-226/245.0
QDIDMEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVS--ENGRVLVF-VHGRSRSASVILAYLM-----KTLEMNFESSWTHLRSKCWHLI
 . | |.....|..  |. | .  ..|   .  ..|..||..  .||.|||   .|..|.. .|.||||     |.|....|.   .|||.... .
nlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgav
0040438 (Phosphotyrosine protein) phosphatases II 224-311 3.9e-10 35.0 In-house 149-262 (317) alignment 
Range on Protein: 224-311
Range on HMM: 149-262/317.0
DMEELKNVHVLKCPVKDK----------------NDENMLPCWEASCSFIDKAVSE----NGRVLV-FVHGRSRSASVILAYLM-----KTLEMNFESSW
..|||....... .|.|.                 | .  | ..   .|.... .     .| |||  ..| .|....|.||||     |. ....|. .
seeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav

THLRSKCWHLIDKS
 .||..... .   
kelreqRpgavqtp
0045450 (Phosphotyrosine protein) phosphatases II 224-308 1.9e-09 33.2 In-house 171-287 (307) alignment 
Range on Protein: 224-308
Range on HMM: 171-287/307.0
DMEELKNVHVLKCPVKDK-----------------NDENMLPCWEASCSFIDKAVS------ENGRVLVF-VHGRSRSASVILAYLMKTLE--------M
..|.|....|.. .|.|.                  | .  | .|  ..||... .      ..|.|||   .| .|....|.||||...         .
seehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldv

NFESSWTHLRSKCWHLI
.... . .||..... .
dlleavkllreqRpgav
0038934 (Phosphotyrosine protein) phosphatases II 224-324 6.7e-09 31.1 In-house 71-175 (194) alignment 
Range on Protein: 224-324
Range on HMM: 71-175/194.0
DMEELKN--VHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH---GRSRSASVILAYLMKTLEMNFESSWTHLRSKCWHLIdKSLVFEEQL
| ||...  ...||.|..|..    |      ....|. ..|.   .| ||   |..|.. .. |||...| |. | .  ..|.|  . |  .  . |.|
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai.pnqdyleal

VQWYRE
...|.|
lkryke
0039614 (Phosphotyrosine protein) phosphatases II 225-308 2e-07 26.2 In-house 180-272 (297) alignment 
Range on Protein: 225-308
Range on HMM: 180-272/297.0
MEELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVS---ENGRVLVF-VHGRSRSASVILAYLM-----KTLEMNFESSWTHLRSKCWHLI
 |...  |..  .  | .  . |      . ....|..   ..|.|||  ..| .|....|.||||     |. ...... . .||..... .
gesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgav
0040439 (Phosphotyrosine protein) phosphatases II 226-308 2.6e-09 32.5 In-house 135-229 (249) alignment 
Range on Protein: 226-308
Range on HMM: 135-229/249.0
EELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVS------ENGRVLVF-VHGRSRSASVILAYLM-----KTLEMNFESSWTHLRSKCWHLI
.. . ..||  .. |  | .  |  |  ..||... .      ..|.|||   .| .|.. .|.||||     |.|....|. . .|||.... .
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgav
subfamily_MKPLT_pd Subfamily MKPLT 226-303 3.5e-09 30.4 In-house 61-139 (164) alignment 
Range on Protein: 226-303
Range on HMM: 61-139/164.0
EELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLMKTLEMNFESSWTHLRSK
   | |  |.  |.|. ||.. .  |    |. .|.   |||||  | |.|||.|| .|.|.|     .. .. .|. .
afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylker
subfamily_MKPLV_pd Subfamily MKPLV 226-303 3.5e-09 30.4 In-house 61-139 (164) alignment 
Range on Protein: 226-303
Range on HMM: 61-139/164.0
EELKNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLMKTLEMNFESSWTHLRSK
   | |  |.  |.|. ||.. .  |    |. .|.   |||||  | |.|||.|| .|.|.|     .. .. .|. .
afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylker
0043336 (Phosphotyrosine protein) phosphatases II 226-308 2.5e-06 22.6 In-house 173-260 (278) alignment 
Range on Protein: 226-308
Range on HMM: 173-260/278.0
EELKNVHVLKCPvKDKNDENMLPCWEASCSFIDKAVSENGRVLVF-VHGRSRSASVILAYLM-----KTLEMNFESSWTHLRSKCWHLI
 .   .| |. |  ..  |.. . ..    ....  ..|| |||  ..| .|.. .|..||.     |......|. . .||..... .
rtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgav
subfamily_PTPMT1_pd Subfamily PTPMT1 229-324 3e-10 34.8 In-house 72-167 (171) alignment 
Range on Protein: 229-324
Range on HMM: 72-167/171.0
KNVHVLKCPVKDKNDENMLPCWEASCSFIDKAVSENGRVLVFVH-GRSRSASVILAYLMKTLEMNFESSWTHLRSKCWHLIDKSlVFEEQLVQWYRE
 .|. |. ...|  ..  |   | .  ||.|  |.  || |  . ||.|||... .||||. ... |. ...|..|  ..  ..    ..| .....
lgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlak.kqwkalqeyeek
0036941 (Phosphotyrosine protein) phosphatases II 232-325 1.1e-08 30.2 In-house 169-273 (297) alignment 
Range on Protein: 232-325
Range on HMM: 169-273/297.0
HVLKCPVKDKNDENMLPCWEASCSFIDKAVS------ENGRVLVF-VHGRSRSASVILAYLM--------KTLEMNFESSWTHLRSKCWHlidkSLVFEE
.|  . ...  | .. ....   .||... .      ..|.|||  ..| .||...|.|.||        |. .... . . .||.....    .   .|
tvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg....avqtle

QLVQWYREL
|....|. |
qyrflyeal
0047943 (Phosphotyrosine protein) phosphatases II 243-322 2.1e-06 22.9 In-house 178-265 (273) alignment 
Range on Protein: 243-322
Range on HMM: 178-265/273.0
DENMLPCWEASCSFIDKAVS------ENGRVLVF-VHGRSRSASVILAYLM-----KTLEMNFESSWTHLRSKCWHlidkSLVFEEQLVQWY
| .  | .|   .||... .      .|| |.|  ..| .|....|...|.     |. ...... . .|||. ..    .   .||... |
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg....mvqtpeqyrfly
subfamily_MSG5_pd Subfamily MSG5 254-324 2e-07 24.3 In-house 89-159 (165) alignment 
Range on Protein: 254-324
Range on HMM: 89-159/165.0
CSFIDKAVSENGRVLVFVH-GRSRSASVILAYLMKTLEMNFESSWTHLRSKCWHlIDKSLVFEEQLVQWYRE
 . |  | |.. ..||    | |||||.|.||.||  .. .. .. .|.|.  . |. |. .  ||..|   
triihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvadd.ispsiglifqlmeweva