Gene SSH in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP017_AA protein Get Run
AqueP017_AA_297-442 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DEK_C DEK C terminal domain 244-291 2.4e-11 32.8 Pfam-A 3-50 (54) alignment 
Range on Protein: 244-291
Range on HMM: 3-50/54.0
DTLIQKLRDVMLHLDLDTASSRQIRQQLENEMMMNLKEYRGFLDQQML
...  ..|...   ||.|....|.|..||... ..|.|.. |..... 
eeikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdlie
0044763 (Phosphotyrosine protein) phosphatases II 281-439 1.8e-40 133.8 In-house 4-171 (178) alignment 
Range on Protein: 281-439
Range on HMM: 4-171/178.0
EYRGFLDQQMLYIVGQLEEPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPES---------FKYKTIRVYDLPESELLKHWDDTYKFIK
..| .|.  . .  ..   .|.| ..||||. ..|..|  |||.|. .|.|.|.|. ......         ..|. | . | .. .||.|......||.
rtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefie

EVK-ERKSKLLVHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQRScIKPNHGFMSQLKAYEGILK
|.  |.... ||||..|..||.. |.|| ||....|||.|...||..|. | || |.. ||. .| .|.
ealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_Slingshot_pd Subfamily Slingshot 282-443 1.6e-85 278.7 In-house 1-165 (169) alignment 
Range on Protein: 282-443
Range on HMM: 1-165/169.0
YRGFLDQQMLYIVGQLEEPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLL
|. |.|..||.|.|||...|||....|||.||||||| ||||.|||||||.|||||||.||.|.|..||||| .|..|||.|..|||||...|...||.|
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKAR---YN
||||||.||||.|||||.||||..|||.||..|...||.||||.||..||..|||||.|.   .|
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhn
subfamily_LRR-DSP_pd Subfamily LRR-DSP 290-438 9.2e-35 114.0 In-house 112-258 (263) alignment 
Range on Protein: 290-438
Range on HMM: 112-258/263.0
MLYIVGQLeePSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTI-RVYDLPESELLKHWDDTYKFIKEVKErKSKLLVHCKMGI
....|  .  |..| . |.||.   | |   ||..|| .||    ... ..|. ||| .|  . | .| .. .|...|  ||.| .. |  .||||. |.
litlvssv..PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGv

SRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
|||.. ||.| ||  |. ...|| .| ..|. |.||.||. ||| ||  |
srsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0036941 (Phosphotyrosine protein) phosphatases II 292-436 9.4e-23 76.4 In-house 11-274 (297) alignment 
Range on Protein: 292-436
Range on HMM: 11-274/297.0
YIVGQLEEPSKIHEYLYLGTEWNASNLLELK----------------------------------------------------------EMGVEYILNMT
.. . |.| ... ..|.||. . |...  |.                                                          | .|. |...|
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

KEIDNFY-------------------------------PESFKYKTIRVYD----------------LPESELLKHWDDTYKFIKEVKE------RKSKL
.....                                  ..... |..|.|                 |.  .  ....  .||..|..      .... 
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

LVHCKMGISRSAATVIAYTM--------KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEG
||||..|..||.. ..|..|        ||..... .|. ..|.|| .. .. ... .|  .. 
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_DSP1_pd Subfamily DSP1 297-438 7e-48 156.8 In-house 14-156 (163) alignment 
Range on Protein: 297-438
Range on HMM: 14-156/163.0
LEEPSK-IHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATV
| .|.. | ..||||.| .||||  ||..|.  |||..||.||.... |.||.. . | |. .. .....  .||.|||. . |.|.||..|||||.. .
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
.|| ||. |.|||.|  ||...||.|.|| ||. ||. ||  |
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 297-435 7.5e-32 103.9 In-house 3-144 (148) alignment 
Range on Protein: 297-435
Range on HMM: 3-144/148.0
LEE-PSKIHE-YLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYP-ESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAA
|.  ||.|.. .|.||    |..|  ||..||  | |.||| || .   . .|  ... | |. .| . ..|  .|....|..  . |||..||.|||.|
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

TVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
 .... ..  |.||..|| .|.|.|  ..||.||..||  .|
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
0045098 (Phosphotyrosine protein) phosphatases II 297-437 7.1e-31 103.0 In-house 19-270 (278) alignment 
Range on Protein: 297-437
Range on HMM: 19-270/278.0
LEEPSKIHEYLYLGTEW-----------------------------------------NASNLLELKEMGVEYILNMTKEIDN-----------------
|  ||.| ..||||  .                                          |...  |.|.|...|...|.....                 
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

-----------------------------------FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKE--------------RKSKLLVHCKMGIS
                                   .. . ..|...  .. |....||.... ..||.|. .              .. . ||||..|..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSAATVIAYTMKEY---RMSLEDALSFVRSQRSC-IKPNHGFMSQLKAYEGI
|... |.||.|.|.   ...|..|....|||| . . .| ... .|  ..  
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_DSP6_pd Subfamily DSP6 298-440 6.2e-41 133.6 In-house 12-156 (158) alignment 
Range on Protein: 298-440
Range on HMM: 12-156/158.0
EEPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPE--SFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATV
| | .| ..||||.. .||||  ||.....|.||.|....|.. |  ..||. | . |  . .| |.. .. .|| | ...|||.||||  ||||| . .
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

IAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKA
.|| ||.. .||.||  .|....| | ||  || ||. .|  |. 
laylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP10_pd Subfamily DSP10 299-440 2.1e-43 141.9 In-house 13-155 (159) alignment 
Range on Protein: 299-440
Range on HMM: 13-155/159.0
EPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPE-SFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIA
. |..  .|.|| | .|..|  |........||.|... |.. | ..||| | | |  . .| ..... ..||.|.... |..||||. ||||||. |||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKA
| ||. ..||.||  ||...|. | || .|| ||. .|  |. 
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP14_pd Subfamily DSP14 299-440 5.7e-39 127.6 In-house 6-146 (157) alignment 
Range on Protein: 299-440
Range on HMM: 6-146/157.0
EPSKIHEYLYLGtEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAY
. |.| ..|.|.    |..  .||. ..  |.|.| |. |   .....  ..| | ||..| ||.| ... |.|||... | ||||..|.||||. ..||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

TMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKA
 ||  ..||..| . |.|.|. |.|| || .|| .||  ||.
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
PTPc_motif_SM00404 299-435 1.9e-38 126.5 In-house 1-138 (140) alignment 
Range on Protein: 299-435
Range on HMM: 1-138/140.0
EPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFY-PESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIA
|||.|...||||.. .|.|.  ||..|.....|.|.|... .  ..|... | . |  ...|.|..| ...||....... | ||||..|.||||. .||
epsrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
| |... .||..|..||...|..|.|| .|. ||  ||
YlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0041856 (Phosphotyrosine protein) phosphatases II 299-438 1.5e-32 108.0 In-house 18-172 (182) alignment 
Range on Protein: 299-438
Range on HMM: 18-172/182.0
EPSKIHEYLYLGTEWN--------------ASNLLELKEMGVEYILNMTKEI---DNFYPESFKYKTIRVYDLPESEllkhWDDTYKFIKEVKERKSKLL
 ...|...||||  ..              |..|  |||.|. .|.|.| |    .... . ..|. . . | .  .    .|....||.||.|.. . |
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQRS--CIKPNHGFMSQLKAYEGIL
|||..|..|... |.|| ||....|||.|...|||.|.  .| ||..|. ||...| .|
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_DSP8_pd Subfamily DSP8 299-440 7.1e-31 100.9 In-house 14-156 (159) alignment 
Range on Protein: 299-440
Range on HMM: 14-156/159.0
EPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKE-IDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIA
.| .| ..||||.. .. .   |...|..|.||. .. ..    .  |.  . | |  . .||  .| ...||  .|. ... |||.  ||||||. .||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKA
| ||. .|||..|  ||...|  |.||  |. ||  ||  || 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 299-435 4.9e-27 88.2 In-house 2-149 (154) alignment 
Range on Protein: 299-435
Range on HMM: 2-149/154.0
EPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPES---------FKYKTIRVYDLPESELLKHWDDTYKFIKEVK--ERKSKLLVHCKMG
..||   .||...   | | |.|..  .. |||.   |.| ...          ..|  ....| .. ..... | ...||..     ...|.|||.. |
rnskeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkG

ISRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
.||||| .|.| |.. ..||  || .... |  ||||.||. ||. .|
vsrsaallisylmdklkislslalellkdsryiikPnqGflkqleife
0048076 (Phosphotyrosine protein) phosphatases II 300-438 3.9e-36 119.2 In-house 4-142 (145) alignment 
Range on Protein: 300-438
Range on HMM: 4-142/145.0
PSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYT
||.| ..||||  ..|..| .||..|. ..||.| |....... ..|  . . | .. .||..... ..||.|. ... . ||||..|..|... |.|| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
|.....|||.|| .|||||... || |.. .|. .| .|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 300-438 1.3e-35 117.5 In-house 4-144 (144) alignment 
Range on Protein: 300-438
Range on HMM: 4-144/144.0
PSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESF--KYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIA
||.| ..||||  . |..| .||..|. ...|.| | .. ..| .  .|  . . | .  .||........||.|. |.. . ||||..|..|... |.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
| ||....|||.|| .|||.|... || |.. .|. || .|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0049772 (Phosphotyrosine protein) phosphatases II 300-441 1.7e-32 108.8 In-house 154-276 (314) alignment 
Range on Protein: 300-441
Range on HMM: 154-276/314.0
PSkiheylylgTEWNASNLLELKemgveyilnmtKEI--DNFYPES-FKYKTIRVYDlPESELLKHWDDTYKFIKEVkERKSKLLVHCKMGISRSA-ATV
.           |..|..| .||           .|.  ......  .||. | |.| ..  ||...|. ..||.|. ......|||||.|..|.. . |
ng.........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvv

IAYTMKEYRMSLEDALSFVRSQRScIKPNHGFMSQLKAYEGILKAR
.|| || ...|||.||..||..|. |.||.||. ||. || ||.|.
aaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefileal
0043147 (Phosphotyrosine protein) phosphatases II 300-443 4.1e-32 106.6 In-house 19-165 (172) alignment 
Range on Protein: 300-443
Range on HMM: 19-165/172.0
PSKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKE---IDNFYPESFKYKTIRVYDLPESeLLKHWDDTYKFIKE--VKERKSKLLVHCKMGISRSAAT
| ..  ..... .  |...  |||.|. .|.|.|..    ...... ..|  . ..| .   ||........||.|  ..... . ||||..|..|... 
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VIAYTMKeYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKARYN
|.|| |. ...|||.|...||..|... .| ... .|. .| .|. ...
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllkd
0046846 (Phosphotyrosine protein) phosphatases II 300-438 9.3e-28 92.6 In-house 12-172 (176) alignment 
Range on Protein: 300-438
Range on HMM: 12-172/176.0
PSKIHEYLYLGTEW----------NASNLLELKEMGVEYILNMTKEI-----------DNFYPESFKYKTIRVYDLPESELlKHWDDTYKFIKEVKERKS
.. |...|.||  .           |..| .|||.|.....|.|.|.           . .. ....|. . . |    .| ..... ..||.|. ... 
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

KLLVHCKMGISRSAATVIAYTMKE-YRMSLEDALSFVRSQRS-CIKPNHGFMSQLKAYEGIL
. ||||..||.|... |.|| ..  . .|.|.||..||.||. .. .. ... .|. .|  |
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0036282 (Phosphotyrosine protein) phosphatases II 300-438 4.3e-24 80.6 In-house 12-169 (174) alignment 
Range on Protein: 300-438
Range on HMM: 12-169/174.0
PSKIHEYLYLGTEWNAsNLLELKEMGVEYILNMTKEI---------------DNFYPESFKYKTIRVYDLPESELLKhWDDTYKFIKEVKER--KSKLLV
 | | ..|..|    | .. .||| |.........|.               . .... ..|. . . |  . .| . ... .||..|. ..  . ..||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCKMGISRSAATVIAYTMKEYRM-SLEDALSFVRSQR---SCIKPNHGFMSQLKAYEGIL
||..|..|... |.|| |. . . ||.|||..||..|   ... .. ... .|  .| .|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_DSP12_pd Subfamily DSP12 301-439 1.7e-37 123.2 In-house 3-144 (155) alignment 
Range on Protein: 301-439
Range on HMM: 3-144/155.0
SKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKE-IDNFY--PESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIA
|.|.. ||||.  .. .   |||.... .| ..|| ....   .   ..|.| ..| || ..|.| |.. .||.|  |.. ..||||..|.|||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILK
| ||....|||.||..|..... |.||.||..||| .| . .
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
subfamily_DSP3_pd Subfamily DSP3 301-438 2e-32 106.1 In-house 12-157 (162) alignment 
Range on Protein: 301-438
Range on HMM: 12-157/162.0
SKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKE----I---DNFYP-ESFKYKTIRVYDLPESELLKHWDDTYKFIKE-VKERKSKLLVHCKMGISRS
  ... ||.| |  |..  .||..|. ..|| ..     .   ..||   ..||  . | | ||..| |... . |||.| ......|.||||..|.|||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

AATVIAYTMKEYRMSLEDALSFVRSQRsCIKPNHGFMSQLKAYEGIL
|. |.|| |   .|.| .|.. ||..| .| ||.||. ||....  |
atlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
subfamily_DSP15_pd Subfamily DSP15 301-441 6e-30 98.3 In-house 3-142 (151) alignment 
Range on Protein: 301-441
Range on HMM: 3-142/151.0
SKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPEsFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTM
||. . ||||   ....   |||  .  ||..  .  .. .. ..||.|.. | |. .| |. ... .|| . . .. . |||| .|.|||.  |.|| |
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKAR
    .. .|||.... .||. .|| || .||| ||    . 
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
0049260 (Phosphotyrosine protein) phosphatases II 301-438 4e-28 93.4 In-house 9-149 (152) alignment 
Range on Protein: 301-438
Range on HMM: 9-149/152.0
SKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNF---YPESFKYKTIRVYDLPESELLKHWDDTYKFIKE-VKERKSKLLVHCKMGISRSAATVI
 ..  ....| .. |...  |||.|. .|...|.. ..     .. ..|. . . | .  .|  . .. ..||..  .... . ||||. |..|... |.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYTMKeYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
|| |. ...|||.|...||..|... ||.|.. .|. .|..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
PTEN_1 301-441 3.3e-27 90.6 In-house 42-194 (196) alignment 
Range on Protein: 301-441
Range on HMM: 42-194/196.0
SKIHEYLYLGTEWNA-SNLLELKEMGVEYILNMTKEIDN---------FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKE--RKSKLLVHCKMGI
..|.| ||.| .  . ..| .|||.|.  ..|.. | ..         |. . ..|. . . | . . | ...|  ..||  ...  .. . ||||| |.
qeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGl

SRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKAR
.||.  |.|| |. .... ..||..||..|... || ... .|. |.  |.|.
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0051082 (Phosphotyrosine protein) phosphatases II 301-434 1.1e-23 79.0 In-house 9-149 (151) alignment 
Range on Protein: 301-434
Range on HMM: 9-149/151.0
SKIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEI------DNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKER-KSKLLVHCKMGISRSAA
| . ..||..    | .| .|||.|. .|.|...|       . .  ...... | . | |.  |  ..|   .|.... .  . ..||||..|..|...
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

TVIAYTMKeYRMSLEDALSFVRSQRS-CIKPNHGFMSQLKAY
 |..| |. ...|||.||...|..|  .. || .|. ||.|.
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP19_pd Subfamily DSP19 302-437 1.2e-42 139.9 In-house 14-149 (152) alignment 
Range on Protein: 302-437
Range on HMM: 14-149/152.0
KIHEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMK
.....||||    |..  .||| .. .|||.. ...|..|. |.|..| ..|||| .||...... .||.|... .  .||||. |.||||. |||| ||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

EYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGI
. ..|||.||. ||..| |||||.||. |||.||  
keelsleealelvrearpcikPneGFikqLkeyeae
0037934 (Phosphotyrosine protein) phosphatases II 302-435 1e-24 82.9 In-house 41-238 (243) alignment 
Range on Protein: 302-435
Range on HMM: 41-238/243.0
KIHEYLYLGTE--------WNASNLLELKEMGVEYILNMTKEI---------------------------------------------DNFYPESFKYKT
.. ..|...          . ||..  |.| |...|...|...                                             |... . ..|  
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IRVYD----LPESELLKHWDDTYKFIKE-----VKERKSKLLVHCKMGISRSAATVIAYTMKEY-RMSLEDALSFVRSQRSC-IKPNHGFMSQLKAYE
. . |       . ||...|....||.|     .  .....||||..|..|... ..||.|... ...||.|. ..|.||.. . .. ... .|  ..
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_MKPLT_pd Subfamily MKPLT 304-437 6.2e-30 97.9 In-house 26-159 (164) alignment 
Range on Protein: 304-437
Range on HMM: 26-159/164.0
HEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEY
.. ||||   .| |   ||.. ...|.|...|  . .|.|..| ...| | ....| .. . . ||. .  .   ..|||| .| |||... .|. .|  
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGI
.  |..| .... .||...|| ||. ||  .| .
gwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 304-437 6.2e-30 97.9 In-house 26-159 (164) alignment 
Range on Protein: 304-437
Range on HMM: 26-159/164.0
HEYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEY
.. ||||   .| |   ||.. ...|.|...|  . .|.|..| ...| | ....| .. . . ||. .  .   ..|||| .| |||... .|. .|  
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGI
.  |..| .... .||...|| ||. ||  .| .
gwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_STYX_pd Subfamily STYX 304-443 1.9e-26 86.1 In-house 16-162 (166) alignment 
Range on Protein: 304-443
Range on HMM: 16-162/166.0
HEYLYLGTEWN--ASNLLELKEMGVEYILNMTKEID-----NFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVI
   |.||       | |  ||. |. .|. . ..|.       .|..|.|  . | | .  .....   . .|| .  ..  |.||| . ||||||| ||
lpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvi

AYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKARYN
|| |. | .   .|  .|. .| ||.||.||.|||| || |  |...
ayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylaklt
subfamily_STYXL1_pd Subfamily STYXL1 305-436 5.3e-25 81.5 In-house 17-151 (157) alignment 
Range on Protein: 305-436
Range on HMM: 17-151/157.0
EYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYP---ESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMK
. ||||.. .| |    |.. |   .|.... |...    .  |  .|.| | .|..||.. ..  .||.. |.... .||  . ||||||| .||| | 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

EYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEG
.....|..|.....  .. .|||..|..||. .| 
skkitlkkaykylkkCkenvkPnrafveqlseWek
0038934 (Phosphotyrosine protein) phosphatases II 305-438 8.2e-20 66.7 In-house 36-176 (194) alignment 
Range on Protein: 305-438
Range on HMM: 36-176/194.0
EYLYLGTEWNASNLLELKEMGVEYILNMTKEIDNFYPESFKYKTIRVYDLPESEL--LKHWDDTYKFIKEVKE-----RKSKLLVHCKMGISRSAATVIA
| ||  . ..  ..|.|. ... .....|..   . || |.   |....||  .       . ...|.. |.|      . . .||||.|..|..  |.|
eelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

YTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL
| .. ..||.|.|. ..|. |  . || .....|  . . |
YLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_MSG5_pd Subfamily MSG5 305-441 3.9e-18 59.1 In-house 32-163 (165) alignment 
Range on Protein: 305-441
Range on HMM: 32-163/165.0
EYLYLGTEWNASNLLELkemgvEYILNMTKEIDNFY--PESFKYKTIRVYDlpESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKE
| ||| .| .  .|| .     . ..|..|||...     . ||  |.     .|.. |      . |.  . .. |.||||. |.||||. ..|| || 
eklylysepklkellsf.....dlvinvakeindlellvpavkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimky

YRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILKAR
| .||.||   ..|.   |.|. |.. ||  .| .|...
ynlslrdaydklksvaddispsiglifqlmewevalskk
0051429 (Phosphotyrosine protein) phosphatases II 306-434 4.4e-18 61.4 In-house 23-220 (272) alignment 
Range on Protein: 306-434
Range on HMM: 23-220/272.0
YLYLGTEW---NASNLLELKEMGVEYILNMTKEI------DNFYPESFKYKTIRVYDLPESELLKHW---------------------------------
.||..  .   .| ..  |||.|. .|.....|         .|.. ..|  . ..|  . . | ..                                 
rlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

---------------DDTYKFIKEVKErKSKLLVHCKMGISRSAATVIAYTMKeYRMS--------------LEDALSFVRSQRSCIKPNHGFMSQLKAY
               .   ...... . . ..||||. |..|..  | .. .  ...|              ||.|.. .|.|| .. .. ... .|  .
mhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
DSPc Dual specificity phosphatase, catalytic domain 307-435 2.9e-34 112.8 Pfam-A 1-131 (133) alignment 
Range on Protein: 307-435
Range on HMM: 1-131/133.0
LYLGTEWNASnLLELKEMGVEYILNMTKEIDN---FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEY
||||.. .|| |  |...|.....|.|||..|   . .....|  | | |  |... |. .....||....... | ||||..||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
..||..|..||...||.| || ||. || .||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 307-435 2.9e-34 112.8 In-house 1-131 (133) alignment 
Range on Protein: 307-435
Range on HMM: 1-131/133.0
LYLGTEWNASnLLELKEMGVEYILNMTKEIDN---FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEY
||||.. .|| |  |...|.....|.|||..|   . .....|  | | |  |... |. .....||....... | ||||..||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
..||..|..||...||.| || ||. || .||
nlslneAyefvkerrskispnagflrqLleye
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 307-439 1.8e-20 66.6 In-house 6-142 (145) alignment 
Range on Protein: 307-439
Range on HMM: 6-142/145.0
LYLGTEWNASNLLELKEMGVEYILNMTKE----IDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKE
|| |.  .|...  |.|.|.  |.||.       .. . ||..   |   ||   .| .|.|.   ||   ||  . ..|||  |.||| .  .|. || 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

YRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGILK
  |.| .|   |||.|    ||  |. .|   |  ||
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0042113 (Phosphotyrosine protein) phosphatases II 308-434 2.4e-22 75.0 In-house 55-238 (245) alignment 
Range on Protein: 308-434
Range on HMM: 55-238/245.0
YLGTEWNASNLL----ELKEMGVEYILNMTKEIDN-------------------------------------------FYPESFKYKTIRVYDLPESELL
...    ....      |.| |...|...|.| ..                                            ..||..  ... .. |.    
iatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvp

KHWDDTYKFIKEVKE-----RKSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAY
 . ..  .|...|..     .. ..||||..|..|... ..||.|     ||...|||.|. ..||||... .. ... .|  .
dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 310-435 1.4e-28 95.6 In-house 39-242 (249) alignment 
Range on Protein: 310-435
Range on HMM: 39-242/249.0
GTEWNASN------------------------LLELKEMGVEYILNMTKEIDN-------------------------------------------FYPE
.   |||                         .  |.| |...|...|..  .                                            ..|
sdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydge

SFKYKTIRVYDLPESELLKHWDDTYKFIKEVKE------RKSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQL
|.... |...|.|.  . .. .|. .||..|..      .....||||..|..|... ..||.|     ||....||.|....||||... .| ... .|
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

KAYE
  ..
yeal
0045450 (Phosphotyrosine protein) phosphatases II 314-434 1.1e-26 89.7 In-house 88-299 (307) alignment 
Range on Protein: 314-434
Range on HMM: 88-299/307.0
NASNL--------------------------------LELKEMGVEYILNMTKEIDN-------FY---------------------PESFKYKTIRVYD
|||                                    |.| ||..|...|.....       ..                      ..... |..| |
NAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtd

L-----------------PESELLKHWDDTYKFIKEVKE------RKSKLLVHCKMGISRSAATVIAYTMKEYR--------MSLEDALSFVRSQRSCIK
|                 |.  . ...... .||.||..      .... ||||..|..|... ..||.|....        ..|..|....|.||... 
ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

PNHGFMSQLKAY
.| ... .|  .
qnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 320-434 1.4e-24 82.4 In-house 105-271 (317) alignment 
Range on Protein: 320-434
Range on HMM: 105-271/317.0
ELKEMGVEYILNMTKEIDN---------------------------FYPESFKYKTIRVYDL----------------PESELLKHWDDTYKFIKEVKER
 ..| ||..|...|.. ..                           .. ..... |..|.||                |.  . ...|.  .|...|.| 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----KSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAY
    ....||||..|..|... ..||.|     ||.....|.|. ..|.||... .. ... .|  .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0039614 (Phosphotyrosine protein) phosphatases II 320-435 1.9e-21 72.3 In-house 120-285 (297) alignment 
Range on Protein: 320-435
Range on HMM: 120-285/297.0
ELKEMGVEYILNMTKEIDN--------------------FYPESFKYKTIRVYDL-------------------PESELLKHWDDTYKFIKEVKE-----
 ..| ||..|...||....                     . . .... . |. |                   |.     . .. ..|...|.|     
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-RKSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
 .. . ||||..|..|... ..||.|     ||.......|....|.||... .. ... .|  ..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 321-434 1.2e-19 66.3 In-house 108-272 (278) alignment 
Range on Protein: 321-434
Range on HMM: 108-272/278.0
LKEMGVEYILNMTKEIDN------------------------------------------FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKE---
..| ||. |...|.. ..                                           ..||..   .  .. |. ..  . ..  .|.|.|.|   
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

-RKSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAY
 .....||||. |..|... ...|..     ||....||.|....|.|| .. ..  .. .|  .
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 321-431 1.2e-16 56.4 In-house 97-264 (273) alignment 
Range on Protein: 321-431
Range on HMM: 97-264/273.0
LKEMGVEYILNMTKEIDN----------------------------------------------FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVK
..| .|..|  .|.....                                               ..||.... . ... |.     ....  .||..|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

E------RKSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPNHGFMSQL
.      .... .|||. |..|... ......     ||.......|. ..|||| .. ..  .. .|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 321-421 1.9e-14 49.2 In-house 128-281 (308) alignment 
Range on Protein: 321-421
Range on HMM: 128-281/308.0
LKEMGVEYILNMTKEIDNF----------------------------------------------YPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVK
. | .|..|  .||...|                                               ..||.... .   . |.     ....  .|...|.
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

ER--KSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCI
..  ... .|||. |..|... ......     ||.......|. ..|.|| . 
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
subfamily_DSP23_pd Subfamily DSP23 321-419 1.5e-07 26.2 In-house 27-126 (148) alignment 
Range on Protein: 321-419
Range on HMM: 27-126/148.0
LKEMGVEYILNMTKEIDNFYP--ESFKYKTIRVYDLPESeLLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQR
| ..|| |.. .|.|         .  .. .|. |      |.  ..  . ..| .|..  . ||| .|  |. . .  | .|| ...  .|.. || .|
lldlgvrylvslteegrphveatpnltlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

S
 
p
0051299 (Phosphotyrosine protein) phosphatases II 322-424 3.3e-15 51.8 In-house 113-271 (288) alignment 
Range on Protein: 322-424
Range on HMM: 113-271/288.0
KEMGVEYILNMTKEIDN-----------------------------------------------FYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVK
 | .|..|  .||....                                               .  ||.... . ... |.     ....  .|...|.
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

ER----KSKLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRSCIKPN
.     ..  .|||. |..|... ......     ||.......|. ..|.|| .. ..
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 324-421 3e-13 45.3 In-house 100-256 (284) alignment 
Range on Protein: 324-421
Range on HMM: 100-256/284.0
MGVEYILNMTKEID---------------------------------------------NFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKER--
 .|..|  .|....                                             ..  ||.. . . . . |.     . .|  .|...|.|   
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

----KSKLLVHCKMGISRSAATVIAYTMKEY--------RMSLEDALSFVRSQRSCI
    ... .|||. |..|... .......|.        ......|....|.|| . 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
ATS acidic terminal segments, variant surface antigen of PfEMP1 324-464 2.3e-06 13.2 Pfam-A 148-282 (437) alignment 
Range on Protein: 324-464
Range on HMM: 148-282/437.0
MGVEYILNMTKEIDNFYPESFKYKTIRVYDLPEsELLKHWDDTYKFIKEVKERKSKLLVHckmgISRSAaTVIAYTMKEYRMSLEDalsFVRSQRSCIkp
.  ..| || .. .|  |.. . . |..   |. .| ..  .   ||  ...|.          .|    ... ..|..  .. ..    | |    |  
LKddFisnmlqneqndvpnnilsdnidlntepn.tlsrdkveeKpFitsihdrnlysgee....ysYni.nmstnsmddikkvskn...dvysgidli..

NHGFM--SQLKAYEGILKARYNDLFGTQAPSRITFQSR---SSSDP
|. .    ..  |. .|| . |.||||. . .....|    ..|||
ndsLsgnkhidiYdevLKRkenelfGtnhtKktstnsvakltnsdp
DSPc_SM00195 331-419 6.3e-06 21.1 In-house 148-242 (263) alignment 
Range on Protein: 331-419
Range on HMM: 148-242/263.0
NMTKEIDnfyPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKS----KLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRS
..||| .    |..| . . . . |.... .. ... .....||..||     ..|||. |..|... | . ..     .| ...... .. .|.|| 
eltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp
PTPc_SM00194 331-419 6.3e-06 21.1 In-house 148-242 (263) alignment 
Range on Protein: 331-419
Range on HMM: 148-242/263.0
NMTKEIDnfyPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKS----KLLVHCKMGISRSAATVIAYTM-----KEYRMSLEDALSFVRSQRS
..||| .    |..| . . . . |.... .. ... .....||..||     ..|||. |..|... | . ..     .| ...... .. .|.|| 
eltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp
subfamily_PTPMT1_pd Subfamily PTPMT1 336-436 1e-16 55.8 In-house 66-166 (171) alignment 
Range on Protein: 336-436
Range on HMM: 66-166/171.0
IDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE
 ...  .  .. .... |  |.  |..  .. .||..|....... |||| | .|||. |..| ||....|.|.||......|. |. ..  ...|. ||
teewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

G
 
e
Y_phosphatase Protein-tyrosine phosphatase 342-419 2e-06 22.8 Pfam-A 131-217 (235) alignment 
Range on Protein: 342-419
Range on HMM: 131-217/235.0
ESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERK----SKLLVHCKMGISRSAATVIAYTMKEYRM-----SLEDALSFVRSQRS
|... | . . . |.... .....  ..|..|...|    ....|||. |..|..  | . .. |        .. .... .|.|| 
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 342-419 2e-06 22.8 In-house 131-217 (235) alignment 
Range on Protein: 342-419
Range on HMM: 131-217/235.0
ESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERK----SKLLVHCKMGISRSAATVIAYTMKEYRM-----SLEDALSFVRSQRS
|... | . . . |.... .....  ..|..|...|    ....|||. |..|..  | . .. |        .. .... .|.|| 
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
subfamily_RNGTT_pd Subfamily RNGTT 344-425 2.9e-06 21.1 In-house 73-162 (189) alignment 
Range on Protein: 344-425
Range on HMM: 73-162/189.0
F--------KYKTIRVYDLPESELLKHWDDTYK-FIKevKERKSKLLVHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQRS-CIKPNH
.        | ..    . ||.|  |..    . |.|  |. .. . |||. |  |.   ...| ...  .|.|.|..  .. |   |. ..
lekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyked
PTPc_DSPc_SM00012 350-419 4.4e-07 25.4 In-house 6-87 (105) alignment 
Range on Protein: 350-419
Range on HMM: 6-87/105.0
RVYDLPESELLKHWDDTYKFIKEVKERKS------KLLVHCKMGISRSAATVIAYTMKEY------RMSLEDALSFVRSQRS
 ... |. .. ...|.  .....||. |.       ..|||. |..|..  | .... .       ...... .. .|.||.
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp
subfamily_PRL_pd Subfamily PRL 355-420 8e-06 20.0 In-house 69-132 (151) alignment 
Range on Protein: 355-420
Range on HMM: 69-132/151.0
PESELLKHWDDTYKFiKEVKERKSKLLVHCKMGISRsAATVIAYTMKEYRMSLEDALSFVRSQRSC
| .|....| .  |  |  .| || . |||  |. | |  ..| .. |  |. |||..|.|..|  
PpeevveeWlellke.kfkeepkstvavhcvaGlGr.aPvlvalalieaGmkyedavefirekrrg
0048567 (Phosphotyrosine protein) phosphatases II 366-446 6.6e-08 27.1 In-house 63-154 (157) alignment 
Range on Protein: 366-446
Range on HMM: 63-154/157.0
TYKFIKEVKERKSKLLVHCKMGI---SRSAATVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYE--------GILKARYNDLF
 .||.| ..... .. ||||.|    .|.|  . .| .. .... |.|. ..|  |  ..| .  .  |  |.        |.|||  ....
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 366-421 2.3e-06 22.0 In-house 180-241 (290) alignment 
Range on Protein: 366-421
Range on HMM: 180-241/290.0
TYKFIKEVKERKSKLLVHCKMGISRS---AATVIAYTMK---EYRMSLEDALSFVRSQRSCI
  . |. || .|.  .|||. |||||   ||  ..| .    .  ..|||.|. .|.||   
llsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqrala
subfamily_CDC14_pd Subfamily CDC14 368-429 1.4e-08 29.0 In-house 254-317 (328) alignment 
Range on Protein: 368-429
Range on HMM: 254-317/328.0
KFIKEVKERKSKLLVHCKMGISRSAATVIAYTMKEYRMSLEDALSFVRSQR--SCIKPNHGFMS
||.. ... . .. |||| |. |  . . .| ||.||.. ..|....|  |  | | | . |. 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfle