Gene AqueDSP-sf1-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily AqueDSP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP018_AA protein Get Run
AqueP018_AA_292-432 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Iso_dh Isocitrate/isopropylmalate dehydrogenase 61-311 1.1e-70 224.6 Pfam-A 2-270 (348) alignment 
Range on Protein: 61-311
Range on HMM: 2-270/348.0
LTLIEGDGIGPEISDSVKEIFKAAK----VPIGWETVSVKPVIGEGGRVTVPEDVIHSMKRNKVGLKGPLETQIGKGAVSLN--LTLRRVFNLYANLRPC
..|..|||||||. .......||.|      . .|.| |     .    ..||. ....|.... |.|...|  ||.. . .  |.||. ..|.|||||.
iallpGDgiGpevveaalkvlkavkekaglelefeevdvGgaaidetgeplpeetleaikeadavllgavgtpkgkevrpeegLlalrkeldlfanlrpv

RSI--EGYKTAYD-----NVDLVTIRENTEGEYSGIEHEVVDG-----VVQSVKLITKDACLRVAQYAFEYARKSGRKMVTAVHKSNIMRRGDgLFLKCC
...   . |. .      .|||| .||.|.| |.|.|.|  .      |....||.....  |.|..|||.|.|.||| ||.|.|.|...  . |. | .
kvfekllvksplkrevvegvdlvivReltggiYfgeekeikgsgfteevavdtklyseeeieriaraAfelAlkrgrkkvtlvdKanvlksse.lwrkiv

FEVSD-KYKDIKFNEMYLDKACLLLVQDPSLFDVLVMPNLYGDILSDLCAGLVGGLGLTPSGSAMSTELG
 || . .|.||.......|.|.  ||..|. |||.|..||.||||||..| |||.|||.|| |  . . .
eevakeeypdielehqlvDsaamqlvkspkqfdVivteNlfGDilSDeaaalvGslGllpSaslgakkva
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 293-432 1.6e-87 284.0 In-house 6-145 (145) alignment 
Range on Protein: 293-432
Range on HMM: 6-145/145.0
LVGGLGLTPSGSAMSTELGISRIVNMAAGSLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
|. |..|.........|||||||||||||||..||||..|||.||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEK
||||||||||||.||||||.|||||..||.||.|||||||
cnmtlseaarqvrsnrllaypnvtflknllnlekqlkeek
0041856 (Phosphotyrosine protein) phosphatases II 293-430 4.1e-23 77.3 In-house 26-174 (182) alignment 
Range on Protein: 293-430
Range on HMM: 26-174/182.0
LVGGLGLT--------------PSGSAMSTELGISRIVNMAaGSLMTSQELYGESITILLITAEDMESYDlsqhFDEVTDFIDKGKEEGAGVFVHCMAGV
|. |   .              ..   |  ||||. |||.. . |   ..|. . |..| .  .|..  |    .||. |||.. .|||  |.|||.|||
lylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGv

SRSVTVSVAFLMKYCNMTLSEAARQVHSNRL--LACPNVTFMRNLFNLQKQLKE
.|. |. .|.|||.....| || ..| | |     .||  |.. |. |...|  
gRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0051082 (Phosphotyrosine protein) phosphatases II 298-421 6.7e-18 60.2 In-house 20-146 (151) alignment 
Range on Protein: 298-421
Range on HMM: 20-146/151.0
GLTPSGSAMSTELGISRIVNMAAGSL--MTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSVAFLMKyCN
|...   ..  ||||. |||.       .  . |  ..|..| |  .|.  ..|...||.| .|...  .  .  |.|||.||..|. |. ...||. ..
gpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg

MTLSEAARQVHSNRL-LACPNVTFMRNL
..| || ..... |  . .||  |.  |
vsleealeeyrlkrpgvvqpnqqflfql
0051429 (Phosphotyrosine protein) phosphatases II 300-424 1.2e-14 50.1 In-house 34-220 (272) alignment 
Range on Protein: 300-424
Range on HMM: 34-220/272.0
TPSGSAMSTELGISRIVNMAAGSLMTS--QELYGESITILLITAEDMESYDLSQHF--------------------------------------------
|. . .   ||||. ||..   . . .   ..| . |..| .  .|.. .. ....                                            
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

----DEVTDFIDKGKEeGAGVFVHCMAGVSRSVTVSVAFLMKyCNMT--------------LSEAARQVHSNRLLACPNVTFMRNLFNL
    ... ....   . |  | |||.||..|. ||....|.   ...              | || ... . |  | .. .... |.. 
gvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
PTPc_motif_SM00404 304-426 3.5e-31 103.0 In-house 20-139 (140) alignment 
Range on Protein: 304-426
Range on HMM: 20-139/140.0
SAMSTELGISRIVNMAAGSLMTsqeLYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQ
.|. ..|||. ..|..    .|      ....|| |  .| |. .||...|.|.|||.. ...|  |.|||.||||||.|. .|.||.| ...|.|| . 
pallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef

VHSNRLLACPNVTFMRNLFNLQK
|...|   .||. |.| |....|
vkerRpiispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 304-426 1.1e-27 91.5 Pfam-A 11-132 (133) alignment 
Range on Protein: 304-426
Range on HMM: 11-132/133.0
SAMSTELGISRIVNMAAGSLMTsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQ
 |. ..|||. ..|..     . ..   ..|. | |  ||... ..|....|...||.| ...|  |.|||.||.||| |. .|.|||. |..|.|| . 
lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyef

VHSNRLLACPNVTFMRNLFNLQK
| ..|   .||. |.| | ....
vkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 304-426 1.1e-27 91.5 In-house 11-132 (133) alignment 
Range on Protein: 304-426
Range on HMM: 11-132/133.0
SAMSTELGISRIVNMAAGSLMTsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQ
 |. ..|||. ..|..     . ..   ..|. | |  ||... ..|....|...||.| ...|  |.|||.||.||| |. .|.|||. |..|.|| . 
lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyef

VHSNRLLACPNVTFMRNLFNLQK
| ..|   .||. |.| | ....
vkerrskispnagflrqLleyer
0048076 (Phosphotyrosine protein) phosphatases II 304-428 1.5e-24 81.8 In-house 22-142 (145) alignment 
Range on Protein: 304-428
Range on HMM: 22-142/145.0
SAMSTELGISRIVNMaagsLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQ
 ..  .||| ...|.     .. . |. . |..| .  .|..  ||.....|. .||..  .||  |.|||.|||.|. |. .|.||......| || ..
lellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealel

VHSNRLLACPNVTFMRNLFNLQKQL
|.| |  |.||. ..| |. ....|
vrsqrpgavpnpgqlrflyefelel
0044763 (Phosphotyrosine protein) phosphatases II 305-431 2.7e-28 94.2 In-house 42-173 (178) alignment 
Range on Protein: 305-431
Range on HMM: 42-173/178.0
AMSTELGISRIVNMAAGSLM-----TSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGK-EEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLS
..  ||||. |||..    .       . . ...|. | |  .|.   ||..||.|...||..   |.|  |.|||.|||.|| |. .|.|||.....| 
ellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsle

EAARQVHSNRLlACPNVTFMRNLFNLQKQLKEE
|| ..|.. |  ..||  ..| |  ....|..|
eaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_DSP1_pd Subfamily DSP1 305-434 4.8e-28 92.3 In-house 37-162 (163) alignment 
Range on Protein: 305-434
Range on HMM: 37-162/163.0
AMSTELGISRIVNMAAGslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQV
 . ..|||. |.|...      .. . .  .   .. || .. |.|..|.|| .|||. |...  |..|| ||.||| |. .|.|||  ...|.||   |
eiLkslgitailnvske....ldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfv

HSNRLLACPNVTFMRNLFNLQKQLKEEKQK
...| .  ||..|...| | .|.|. |..|
kqrRsiisPnagFvlqLlnyekklllelek
0048179 (Phosphotyrosine protein) phosphatases II 305-427 8.7e-25 82.5 In-house 23-143 (144) alignment 
Range on Protein: 305-427
Range on HMM: 23-143/144.0
AMSTELGISRIVNMAAGSLMTSQELYgeSITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQV
..  .|||. ..|.. .  ... | .   |..| .  .|..  ||.....|. .||..  |||  |.|||.|||.|. |. .|.|||.....| || ..|
ellkklgittvinlteeyepeflere..giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalv

HSNRLLACPNVTFMRNLFNLQKQ
.| |  |.||  ..| | ...|.
rsrrpgavpnpgqlrfLleyekl
0036282 (Phosphotyrosine protein) phosphatases II 305-427 1.8e-18 62.3 In-house 30-168 (174) alignment 
Range on Protein: 305-427
Range on HMM: 30-168/174.0
AMSTELGISRIVNMAAGSLMT-----------SQELYGESITILLITAEDMESYDLSQhFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLMK
.|  ||||. .|..     .            .. |. . |..| .  .|..  |||. ..|. .|...  .|  |  | |||.|||.|. |. .|.||.
emlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylml

YCNM-TLSEAARQVHSNR---LLACPNVTFMRNLFNLQKQ
.. . .| .| . |.. |     ....  ..| |  ..|.
rglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_DSP12_pd Subfamily DSP12 306-426 4.6e-29 95.8 In-house 22-141 (155) alignment 
Range on Protein: 306-426
Range on HMM: 22-141/155.0
MSTELGISRIVNMAAGSLMTSQELYGESItILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVH
. .||.|.... ..  .| . ..  |.    . |.. |... |. .|.||..|||... ||.  |.|||.||||||||. .|.|||. .. |..| . |.
llkelkithvlsvikeelpehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvk

SNRLLACPNVTFMRNLFNLQK
. .  ..||  |.. |   .|
ekkpeiepNegFleQLklfek
subfamily_DSP8_pd Subfamily DSP8 306-431 3e-23 76.1 In-house 35-157 (159) alignment 
Range on Protein: 306-431
Range on HMM: 35-157/159.0
MSTELGISRIVNMAAgSLMTSQELYGESitILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVH
. ..|||| ..|.   | ....||  .   .| .  .|  . .|.. ||. ..|||| |.| . |.||..|| ||| || .|..||. .|.| || | |.
llsklgisyvlnasn.scpkleelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvk

SNRLLACPNVTFMRNLFNLQKQLKEE
. | .  ||. |.  |.. .|.|| .
ekrptispnlnflgqLleyekelkll
0043147 (Phosphotyrosine protein) phosphatases II 306-428 3.3e-23 77.7 In-house 39-160 (172) alignment 
Range on Protein: 306-428
Range on HMM: 39-160/172.0
MSTELGISRIVNMAaGSLMTSQELYGESITILLITAEDMESYdLSQHFDEVTDFIDK--GKEEGAGVFVHCMAGVSRSVTVSVAFLMKyCNMTLSEAARQ
|  ||||. |||.  . | . . |. . |..| .  .|.    |.....|. .|||.   ...|  | |||.|||.|..|. .|.||. ....| || ..
mlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeaval

VHSNRLLACPNVTFMRNLFNLQKQL
| . |  |..|  ..| |  ..|.|
vrekRpgavqnpsqyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 306-429 5.8e-21 70.5 In-house 42-173 (176) alignment 
Range on Protein: 306-429
Range on HMM: 42-173/176.0
MSTELGISRIVNMAAGS-------LMTSQELYGESITILLITAEDMESYDLsQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY-CNMTL
|  ||||. .||.               .||....|..| .  .|.   || ....|. .||..  .||  | |||.||..|. |. .|.|... .....
mlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsv

SEAARQVHSNRL-LACPNVTFMRNLFNLQKQLK
 || ..| . |   | ..  ..| |    ..|.
eealalvreqRplgavqtpeQyrflyefellll
0040439 (Phosphotyrosine protein) phosphatases II 306-426 1e-20 69.9 In-house 73-243 (249) alignment 
Range on Protein: 306-426
Range on HMM: 73-243/249.0
MSTELGISRIVNMAAGSLMTSQE---------------------------------------LYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKE-
|  ||||. ||..     .  .                                         .|||.|.| |   |.  ......|... |||.. .. 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
     .|  |.|||.|||.|. |. .|.||     |.....| || ... | |  |..|  ..| | .. .
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_MKPLT_pd Subfamily MKPLT 306-423 4.9e-20 65.7 In-house 42-155 (164) alignment 
Range on Protein: 306-423
Range on HMM: 42-155/164.0
MSTELGISRIVNMAAGSlmtsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVH
....| |  |||.. .     .. . .|.  | .  ||     ||.... ...|. .  . |  |.|||  |.||| .|.||||.|.   || ||   . 
vlkdlkithivnvsqek....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylk

SNRLLACPNVTFMRNLFN
  | .. ||  |...| .
errsivapnrGflkqlak
subfamily_MKPLV_pd Subfamily MKPLV 306-423 4.9e-20 65.7 In-house 42-155 (164) alignment 
Range on Protein: 306-423
Range on HMM: 42-155/164.0
MSTELGISRIVNMAAGSlmtsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVH
....| |  |||.. .     .. . .|.  | .  ||     ||.... ...|. .  . |  |.|||  |.||| .|.||||.|.   || ||   . 
vlkdlkithivnvsqek....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylk

SNRLLACPNVTFMRNLFN
  | .. ||  |...| .
errsivapnrGflkqlak
0037934 (Phosphotyrosine protein) phosphatases II 306-427 1.2e-18 63.0 In-house 67-240 (243) alignment 
Range on Protein: 306-427
Range on HMM: 67-240/243.0
MSTELGISRIVNMAAGS----------------------------------------LMTS-QELYGESITILLITAED----MESYDLSQHFDEVTDFI
|  ||||. ||..                                             ... ..|. . | .. .   |     .  || ...|||..||
mlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefi

DK-----GKEEGAGVFVHCMAGVSRSVTVSVAFLMKYC-NMTLSEAARQVHSNRLL-ACPNVTFMRNLFNLQKQ
..        .|  | |||.|||.|. |. .|.||... ...| || ... . |   |...  ..| |  . ..
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 306-425 2.5e-16 55.3 In-house 71-239 (245) alignment 
Range on Protein: 306-425
Range on HMM: 71-239/245.0
MSTELGISRIVNMAAGSLMT------------------------------------------SQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKG
|  ||||. ||..     .                                               . | |... .  .|.   ||....... .|..| 
mlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrka

KE--EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQ
 .  ..  |.|||.|||.|. |. .|.||     |.....| || ... | |  |...  ..| |  . 
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0049260 (Phosphotyrosine protein) phosphatases II 307-428 4.7e-21 70.5 In-house 29-149 (152) alignment 
Range on Protein: 307-428
Range on HMM: 29-149/152.0
STELGISRIVNMAAGSLmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDK-GKEEGAGVFVHCMAGVSRSVTVSVAFLMKyCNMTLSEAARQVH
  ||||. ||..   .     .   . |..| .  .|.  .||||..... .||.|  ...|  |.|||.|||.|. |. .|.||. ....| || ..| 
lkelgittivmltelle.lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvr

SNRLLACPNVTFMRNLFNLQKQL
. |  |.||  ..| |.. .|.|
ekRpgavpnpgqlrflyefekll
subfamily_DSP3_pd Subfamily DSP3 308-432 1.1e-30 100.4 In-house 33-161 (162) alignment 
Range on Protein: 308-432
Range on HMM: 33-161/162.0
TELGISRIVNMAAGSL---MTSQELYG-ESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAAR
..|||  ..| |.|..    | .| |   .|. | . ..|. . |||..|.....|||.  ..  . |.|||..||||| |. .|.|| . .||| || |
kklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveair

QVHSNRLLaCPNVTFMRNLFNLQKQLKEEK
.|...| . .||  |.. | .|...||..|
tvrkkRei.lPneGFlkqLaeldeelkrkk
subfamily_DSP14_pd Subfamily DSP14 308-435 3.9e-30 98.9 In-house 28-151 (157) alignment 
Range on Protein: 308-435
Range on HMM: 28-151/157.0
TELGISRIVNMAAgslmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
.. .|. |.|..       ..   ..|  . ...||... .|..|||||.| |.. |..|  . |||.|||||| .. .|.|||| ...| || ..|.| 
kkkkitliinvtv....elpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksa

RLLACPNVTFMRNLFNLQKQLKEEKQKK
| . .||| | ..| .. |.||...  |
RpiirPNvGFwkqlidyEkklkgkssvk
subfamily_DSP10_pd Subfamily DSP10 308-432 1e-29 97.5 In-house 36-157 (159) alignment 
Range on Protein: 308-432
Range on HMM: 36-157/159.0
TELGISRIVNMAAGSLMTSQElygESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
 .|.|. ..|... . ....|   |...   | ..| .. .|.|.|.|  .||.. ...|. |.|||.||.|||.|| .|.|||. |..|..| . |...
drlnitavlnvttsvPnefee...ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkek

RLLACPNVTFMRNLFNLQKQLKEEK
|    ||..|| .| .. |.|...|
rpiisPnLnfmGqLlefekelnksk
subfamily_DSP6_pd Subfamily DSP6 308-430 1.3e-27 90.2 In-house 36-156 (158) alignment 
Range on Protein: 308-430
Range on HMM: 36-156/158.0
TELGISRIVNMAAGSLMTSQElyGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
..|.|....|..     . .|   .... | |..||  | .|...| |  .|||..... ..|.|||.||.|||||| .|.|||. ...| .|   |.. 
kklkikyvlnvtsnlpnkfee..sgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkr

RLLACPNVTFMRNLFNLQKQLKE
.    ||  ||  | . ...|. 
ksnisPnfnfmgqlldferslrl
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 308-426 9.9e-23 74.3 In-house 30-145 (148) alignment 
Range on Protein: 308-426
Range on HMM: 30-145/148.0
TELGISRIVNMAAGSLMTSQELygeSITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
 .||..||||...   .. ..    .|  | .. .| . .|||. |.....|..| |.||  | ||.  |||||  .....|... ...| ||.  |.|.
kalgvtrivnatkerdnaldqr...gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvksk

RLLACPNVTFMRNLFNLQK
|    ||  |.. | .|..
rryvdpnlgfLkqLaeleq
PTEN_1 308-432 1.7e-19 65.4 In-house 64-195 (196) alignment 
Range on Protein: 308-432
Range on HMM: 64-195/196.0
TELGISRIVNMAAGSL-----MTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEA
 | ||  .||.. ..       . .| . . .. | .  ||    .||..||.. .||.  .  ..|  | ||| ||..||.||  |.||.. ..|  ||
kedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeA

ARQVHSNRLLACPNVTFMRNLFNLQKQLKEEK
 . | . |  ..|| .... | . ...|..||
lelvrekRppgapnspsqerlleyfaellaek
subfamily_DSP23_pd Subfamily DSP23 308-408 6e-06 21.0 In-house 28-125 (148) alignment 
Range on Protein: 308-408
Range on HMM: 28-125/148.0
TELGISRIVNMAAGSLMTSQELygESITILLITAEDMESYDLSQhFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
 .||.  .| ..  .   ..     ..|.  .  .|.    | |  .|    ... .| .  | |||. |  |. |.   .|.|  ... .||  .|   
ldlgvrylvslteegrphveat..pnltlvrlriddyhppaleq.vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

R
|
r
subfamily_DSP19_pd Subfamily DSP19 309-428 2.3e-27 90.2 In-house 35-150 (152) alignment 
Range on Protein: 309-428
Range on HMM: 35-150/152.0
ELGISRIVNMAAGslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNR
| .|  |.|.|.|     .... . .|.| |   | .  ||.....|..|||......   |.||| ||||||..| .|.|||  ...|.|| ..|.. |
ekkitHilnvatg....vpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrear

LLACPNVTFMRNLFNLQKQL
  ..||  |.. | .....|
pcikPneGFikqLkeyeael
0045098 (Phosphotyrosine protein) phosphatases II 309-429 3.8e-19 64.6 In-house 86-272 (278) alignment 
Range on Protein: 309-429
Range on HMM: 86-272/278.0
ELGISRIVNMAAGS---------------------------------------------LMTSQELYGESITILLI-TAEDMESYDLS--QHFDEVTDFI
||||. ||...                                                 .  ..|.   .|.| . . .|... .|.  ..|.|...||
elgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefi

DKGKE--------------EGAGVFVHCMAGVSRSVTVSVAFLMKYC---NMTLSEAARQVHSNRLL-ACPNVTFMRNLFNLQKQLK
..  .              .|  |.|||.|||.|. |. .|.||...   ...| || ... | |   |..|  ..| |. .. .| 
realkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0045450 (Phosphotyrosine protein) phosphatases II 309-426 5.8e-19 64.4 In-house 129-301 (307) alignment 
Range on Protein: 309-426
Range on HMM: 129-301/307.0
ELGISRIVNMAAGSLM------------------------TSQELYGESITILLITAEDM-----------------ESYDLSQHFDEVTDFIDKGKE--
|.|.. ||..     .                        .  | . ...|.. .. .|.                   ......|.|. |||.. ..  
eqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

----EGAGVFVHCMAGVSRSVTVSVAFLMKYCN--------MTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
    .|  | |||.|||.|. |. .|.||...         ..| || ... . |  |..|  ..| | .. .
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 309-427 4.1e-17 57.9 In-house 108-274 (317) alignment 
Range on Protein: 309-427
Range on HMM: 108-274/317.0
ELGISRIVNMAAGSL-----------------------MTSQELYGESITILLITAEDM----------------ESYDLSQHFDEVTDFIDKGKEE---
|.|.. ||..                             . .| . ..||.. .. ||.                  ... ...|.. ||... .|    
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

-GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQ
 |  | |||.|||.|. |. .|.||     |...... || ... . |  |...  ..| |  .  .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
subfamily_Slingshot_pd Subfamily Slingshot 311-435 1.3e-21 70.7 In-house 44-164 (169) alignment 
Range on Protein: 311-435
Range on HMM: 44-164/169.0
GISRIVNMAAgslmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLL
|.. |.|..       .. . |... | |   | |. || ....|  .||.| |..|. |.|||  ||||| .. .|. ||  ...| || . |...| .
gveyilnvtk....eidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsv

ACPNVTFMRNLFNLQKQLKEEKQKK
. || .|.. | . .  |. .||..
ikPnkgflkqleeyeGileaskqrh
subfamily_DSP15_pd Subfamily DSP15 312-434 9.7e-25 81.4 In-house 28-145 (151) alignment 
Range on Protein: 312-434
Range on HMM: 28-145/151.0
ISRIVNMAAgslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLA
|. |...       ... . . |. ..|.|.|  | .||..|.|  .|| | . .. .|.|||.||||||||. ||.||   ..   .| . .. .| .|
ithilsvhd.....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsva

CPNVTFMRNLFNLQKQLKEEKQK
 ||. | | | . .|.  .| .|
nPnfGfkrqlkeyektklkeyrk
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 312-399 6.9e-06 16.3 Pfam-A 319-410 (451) alignment 
Range on Protein: 312-399
Range on HMM: 319-410/451.0
ISRIVNMAAGSLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLS--E
.. .... .  .....|   ..   | .... ..| .|.........||..  ..     ..|.|  |   ||.| .| | .| . . .  .
vdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkk
subfamily_PTEN_pd Subfamily PTEN 315-407 5.6e-06 21.4 In-house 64-154 (184) alignment 
Range on Protein: 315-407
Range on HMM: 64-154/184.0
IVNMAAGSLMTSQELYGeSITILLITAEDMESYDLS-QHFDEVTDFIDKGKEEgaGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
| |....    |... |  .... .. .   . .|  .  ......... |..   | |||.||  |. .. ||.|.|.. .. .| |......
iynlrserkydskkfdg.rvavypfdDhnppplelleeivediekwleedkkn..vvvvHCkaGkGRtGvlivayllkslllekaeealelfae
0049772 (Phosphotyrosine protein) phosphatases II 316-429 1.5e-24 82.7 In-house 167-274 (314) alignment 
Range on Protein: 316-429
Range on HMM: 167-274/314.0
VnmaagSLMTSQELYGES-ITILLITAEDmESYDLSQHFDEVTDFIDKGkEEGAGVFVHCMAGVSRSVT-VSVAFLMKYCNMTLSEAARQVHSNRLlACP
      . ....||. .  |. | |  .| .| .|...|||. .||..  ..|  |.|||.||..|. | | .|.|||.....| || ..|.. |  ..|
k.....eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inp

NVTFMRNLFNLQKQLK
|  |...| .....|.
npgfieqleqyefile
subfamily_STYXL1_pd Subfamily STYXL1 320-431 4.7e-17 55.6 In-house 48-156 (157) alignment 
Range on Protein: 320-431
Range on HMM: 48-156/157.0
AGSLMTSQElygESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMR
|. |.....   .   .| |. || .  || ....|. .||.| |.||  |.|    |.|||..| .|.|| . ..|| .|  ...  .   .|| .|. 
adkliagva...dvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafve

NLFNLQKQLKEE
 | . .||| .|
qlseWekqllge
subfamily_Laforin_pd Subfamily Laforin 325-408 1.5e-06 21.2 In-house 67-151 (183) alignment 
Range on Protein: 325-408
Range on HMM: 67-151/183.0
TSQELYG-ESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNR
| . ||  | .. . .  ||. .    . . .   ..    |.|  |.||| ||| || .. . ||.   . .|.    .. ..|
tlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
subfamily_LRR-DSP_pd Subfamily LRR-DSP 326-428 3.1e-24 79.5 In-house 156-258 (263) alignment 
Range on Protein: 326-428
Range on HMM: 156-258/263.0
SQELYGESITILLI-TAEDMESYDLSQHFDEVTDFIDKGKEEGaGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNL
 . |. .    | |  .||.. .|.||||.|.  ||..|...| ||.||| |||||| |. ...|||. .... ||   | ..|    ||  |. .|   
fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky

QKQL
.|.|
ekkl
0036941 (Phosphotyrosine protein) phosphatases II 327-429 3.5e-16 54.8 In-house 130-277 (297) alignment 
Range on Protein: 327-429
Range on HMM: 130-277/297.0
QELY-------------------------------GESITILLITAEDMESYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFL
..|.                               ||| |.  .   .   ... ...... |||.. ..      .|  | |||.|||.|| |. .|.|
esltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadl

M--------KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLK
|        |...... || ... . |  |.... ..| |  .  .| 
mlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_PTPMT1_pd Subfamily PTPMT1 327-409 1.9e-13 45.2 In-house 67-149 (171) alignment 
Range on Protein: 327-409
Range on HMM: 67-149/171.0
QELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRL
.|   . ...| ..  |.      ..  .  .||.| ...|  |.||| || .|| |.  ..|||  .... || . ... | 
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 330-429 6.4e-16 52.1 In-house 52-153 (154) alignment 
Range on Protein: 330-429
Range on HMM: 52-153/154.0
YGESITILLITAEDMESYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQ
 |  |  | .   |   .|. ...| . .|||.     |  .|.||. .||||| .. ...||.  ...||.|   ... |    ||  |.. |   .|.
dgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke

LK
|.
ll
0039614 (Phosphotyrosine protein) phosphatases II 330-428 8.5e-16 53.7 In-house 165-288 (297) alignment 
Range on Protein: 330-428
Range on HMM: 165-288/297.0
YGESITILLITA-----------------EDMESYDLSQHFDEVTDFIDKGKE---EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQV
. . .|.  ..                   |.   .......|. .....  .   .|  | |||.|||.|. |. .|.||     |...... || ...
hldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkel

HSNRLLACPNVTFMRNLFNLQKQL
 . |  |...  ..| |... ..|
reqRpgavqtpsqyrflydallel
0047943 (Phosphotyrosine protein) phosphatases II 330-421 7.3e-11 37.5 In-house 162-264 (273) alignment 
Range on Protein: 330-421
Range on HMM: 162-264/273.0
YGESITILLITAEDMESYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFM
.||| |.  .   .   ..  ...... .||.. ..      ..  | |||.|||.|. |. ...|.     |. .... || ... | |  . ... ..
tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy

RNL
| |
rfl
0050432 (Phosphotyrosine protein) phosphatases II 331-417 2.6e-09 32.3 In-house 194-287 (308) alignment 
Range on Protein: 331-417
Range on HMM: 194-287/308.0
GESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTF
|||.|.  .   . . ..  ...... ||... ..   |  . |||.|||.|. |. .. |.     | ..... || ... . |  . ...  
gesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0046845 (Phosphotyrosine protein) phosphatases II 331-418 1.1e-08 30.2 In-house 162-263 (284) alignment 
Range on Protein: 331-418
Range on HMM: 162-263/284.0
GESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE------GAGVFVHCMAGVSRSVTVSVAFLMKYC--------NMTLSEAARQVHSNRLLACPNVT
|||.|.  .   .   ..  .... . .|... .|       |  . |||.|||.|. |. .. |....        .... || ... . |  .  .. 
gesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

FM
 .
qy
0051299 (Phosphotyrosine protein) phosphatases II 333-419 3.2e-09 32.1 In-house 181-276 (288) alignment 
Range on Protein: 333-419
Range on HMM: 181-276/288.0
SITILLITAEDMESYDLSQHFDEVTDFIDKGKEE----GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMR
|.|.  .   .   ..  ...... ||. . ..     |  | |||.|||.|. |. ...|.     |   ... || ... . |  .....  .|
srtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr
subfamily_STYX_pd Subfamily STYX 334-426 6.1e-12 38.9 In-house 63-155 (166) alignment 
Range on Protein: 334-426
Range on HMM: 63-155/166.0
ITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
.  |..   |    .. ... .| .|||.  ..|  |.||  ||.||| .. .|..|.   .   || . |  .|.   ||  |...| . . 
frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0043336 (Phosphotyrosine protein) phosphatases II 339-423 2.5e-13 45.6 In-house 181-271 (278) alignment 
Range on Protein: 339-423
Range on HMM: 181-271/278.0
ITAEDMESY-DLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFN
.   |..   .||...| . ..... . ..  | |||.|||.|. |. ...|.     |.....| || ... . |  |...  ..| |..
lgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
subfamily_DSP11_pd Subfamily DSP11 339-424 3.3e-07 24.4 In-house 87-173 (178) alignment 
Range on Protein: 339-424
Range on HMM: 87-173/178.0
ITAEDMESYDLSQHF-DEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNL
.. ..... .| ..| ..|..|..| |.... . |||  || |.  .   .|.. ...  ..| .. .. |  .     ....| .|
cpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
0038934 (Phosphotyrosine protein) phosphatases II 348-430 1.2e-14 49.9 In-house 97-178 (194) alignment 
Range on Protein: 348-430
Range on HMM: 97-178/194.0
DLSQHFDEVTDFIDkGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKE
.. ..| .. |..   . .|  | |||.||..|. |. .|.|.....|.. || . . . |  | ||. ... |.   |.|..
eillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
subfamily_MSG5_pd Subfamily MSG5 351-428 1.4e-10 34.5 In-house 83-160 (165) alignment 
Range on Protein: 351-428
Range on HMM: 83-160/165.0
QHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
. . ..|  |   . ..  ..|||  |.||| .. ||..||| |..| .|  ...|      |.. .. .|.. .  |
kdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0048567 (Phosphotyrosine protein) phosphatases II 355-423 5e-06 21.0 In-house 62-135 (157) alignment 
Range on Protein: 355-423
Range on HMM: 62-135/157.0
EVTDFIDKGKEEGAGVFVHCMAGV---SRSVTVSVAFLMKYCNMTLSEAARQVHSNR--LLACPNVTFMRNLFN
 . .|..  ...|  . ||| ||    .|..|.  ..|......| .|| . .   |  ..  .  ...  |.|
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn