Gene AqueDSP-sf1-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily AqueDSP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP019_AA protein Get Run
AqueP019_AA_64-209 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MKPLT_pd Subfamily MKPLT 58-200 2.6e-23 76.3 In-house 21-155 (164) alignment 
Range on Protein: 58-200
Range on HMM: 21-155/164.0
PSLVYKAdngfRLYIGSAFHAQDLPCLHELGISRIVNMAAGSlmtsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSR
||.| .     .|| | | ||..   |..| |  |||.. .     .. . .|.  | .  ||     ||.... ...|. .  . |  |.|||  |.||
psvvled....tlylGnakhatnekvlkdlkithivnvsqek....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksr

SVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFN
| .|.||||.|.   || ||   .   | .. ||  |...| .
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlak
subfamily_MKPLV_pd Subfamily MKPLV 58-200 2.6e-23 76.3 In-house 21-155 (164) alignment 
Range on Protein: 58-200
Range on HMM: 21-155/164.0
PSLVYKAdngfRLYIGSAFHAQDLPCLHELGISRIVNMAAGSlmtsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSR
||.| .     .|| | | ||..   |..| |  |||.. .     .. . .|.  | .  ||     ||.... ...|. .  . |  |.|||  |.||
psvvled....tlylGnakhatnekvlkdlkithivnvsqek....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksr

SVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFN
| .|.||||.|.   || ||   .   | .. ||  |...| .
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlak
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 65-209 7e-95 307.8 In-house 1-145 (145) alignment 
Range on Protein: 65-209
Range on HMM: 1-145/145.0
DNGFRLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVA
.||||||.|||.||.|.|.|.|||||||||||||||..||||..|||.||||||||.|||||||||||||||||||||||||||||||||||||||||||
angfrlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsva

FLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEK
|||||||||||||||||.||||||.|||||..||.||.|||||||
flmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkeek
0037934 (Phosphotyrosine protein) phosphatases II 65-204 1.9e-22 75.4 In-house 44-240 (243) alignment 
Range on Protein: 65-204
Range on HMM: 44-240/243.0
DngfRLYIGSA--------FHAQDLPCLHELGISRIVNMAAGS----------------------------------------LMTS-QELYGESITILL
.   ||.....         .|...  |.||||. ||..                                             ... ..|. . | .. 
p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

ITAED----MESYDLSQHFDEVTDFIDK-----GKEEGAGVFVHCMAGVSRSVTVSVAFLMKYC-NMTLSEAARQVHSNRLL-ACPNVTFMRNLFNLQKQ
.   |     .  || ...|||..||..        .|  | |||.|||.|. |. .|.||... ...| || ... . |   |...  ..| |  . ..
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 66-208 7.7e-34 112.2 In-house 29-173 (178) alignment 
Range on Protein: 66-208
Range on HMM: 29-173/178.0
NgfrLYIGSAFHAQDLPCLHELGISRIVNMAAGSLM-----TSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGK-EEGAGVFVHCMAGVSRSV
.   ||.||. .|.||. |.||||. |||..    .       . . ...|. | |  .|.   ||..||.|...||..   |.|  |.|||.|||.|| 
g...lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsg

TVSVAFLMKYCNMTLSEAARQVHSNRLlACPNVTFMRNLFNLQKQLKEE
|. .|.|||.....| || ..|.. |  ..||  ..| |  ....|..|
tlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 68-203 4.3e-28 91.7 In-house 14-145 (148) alignment 
Range on Protein: 68-203
Range on HMM: 14-145/148.0
FrLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQELygeSITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLM
| |..||  .| ||  |..||..||||...   .. ..    .|  | .. .| . .|||. |.....|..| |.||  | ||.  |||||  .....|.
f.LFlGskksaadlealkalgvtrivnatkerdnaldqr...gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwli

KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
.. ...| ||.  |.|.|    ||  |.. | .|..
dfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0049772 (Phosphotyrosine protein) phosphatases II 68-206 1.9e-26 89.0 In-house 155-274 (314) alignment 
Range on Protein: 68-206
Range on HMM: 155-274/314.0
FrlyigSAFHAQDLPCLHelgisrivnmaagSLMTSQELYGES-ITILLITAEDmESYDLSQHFDEVTDFIDKGkEEGAGVFVHCMAGVSRSVT-VSVAF
.     .  .|.||. |.             . ....||. .  |. | |  .| .| .|...|||. .||..  ..|  |.|||.||..|. | | .|.
g.....neptaadlellk.............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay

LMKYCNMTLSEAARQVHSNRLlACPNVTFMRNLFNLQKQLK
|||.....| || ..|.. |  ..||  |...| .....|.
lmkllgvsleealedvrlkRp.inpnpgfieqleqyefile
0045098 (Phosphotyrosine protein) phosphatases II 68-207 1.2e-22 76.0 In-house 27-273 (278) alignment 
Range on Protein: 68-207
Range on HMM: 27-273/278.0
FRLYIGSAF-----------------------------------------HAQDLPCLHELGISRIVNMAAGS---------------------------
. ||.|..                                          .|... .|.||||. ||...                              
palylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtll

------------------LMTSQELYGESITILLI-TAEDMESYDLS--QHFDEVTDFIDKGKE--------------EGAGVFVHCMAGVSRSVTVSVA
                   .  ..|.   .|.| . . .|... .|.  ..|.|...||..  .              .|  |.|||.|||.|. |. .|
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

FLMKYC---NMTLSEAARQVHSNRLL-ACPNVTFMRNLFNLQKQLKE
.||...   ...| || ... | |   |..|  ..| |. .. .| .
ylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 68-202 3.1e-19 64.8 In-house 52-239 (245) alignment 
Range on Protein: 68-202
Range on HMM: 52-239/245.0
FRLYIGSAFHAQDLP----CLHELGISRIVNMAAGSLMT------------------------------------------SQELYGESITILLITAEDM
 ....... ......     |.||||. ||..     .                                               . | |... .  .|.
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

ESYDLSQHFDEVTDFIDKGKE--EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQ
   ||....... .|..|  .  ..  |.|||.|||.|. |. .|.||     |.....| || ... | |  |...  ..| |  . 
gvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 68-206 2.9e-18 59.7 In-house 8-153 (154) alignment 
Range on Protein: 68-206
Range on HMM: 8-153/154.0
FRLYIGSAFHAQDLPCLHELGISRIVNMAAGS--LMTSQ---ELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVT
  |||.|   | .   |..  |  |.|.. |.  |.| .      |  |  | .   |   .|. ...| . .|||.     |  .|.||. .||||| .
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLK
. ...||.  ...||.|   ... |    ||  |.. |   .|.|.
llisylmdklkislslalellkdsryiikPnqGflkqleifekell
subfamily_DSP3_pd Subfamily DSP3 69-209 1e-35 116.8 In-house 17-161 (162) alignment 
Range on Protein: 69-209
Range on HMM: 17-161/162.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSL---MTSQELYG-ESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSV
.||.| .  |.|   |..|||  ..| |.|..    | .| |   .|. | . ..|. . |||..|.....|||.  ..  . |.|||..||||| |. .
klyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvl

AFLMKYCNMTLSEAARQVHSNRLLaCPNVTFMRNLFNLQKQLKEEK
|.|| . .||| || |.|...| . .||  |.. | .|...||..|
ayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkrkk
PTPc_motif_SM00404 69-203 1.6e-35 117.0 In-house 8-139 (140) alignment 
Range on Protein: 69-203
Range on HMM: 8-139/140.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTsqeLYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||. .||....| .|||. ..|..    .|      ....|| |  .| |. .||...|.|.|||.. ...|  |.|||.||||||.|. .|.||.
hlylgskskaqnpallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
| ...|.|| . |...|   .||. |.| |....|
yrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP12_pd Subfamily DSP12 69-203 6.2e-33 108.4 In-house 8-141 (155) alignment 
Range on Protein: 69-203
Range on HMM: 8-141/155.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQELYGESItILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.|.. ..|. . |.||.|.... ..  .| . ..  |.    . |.. |... |. .|.||..|||... ||.  |.|||.||||||||. .|.|||
glylggleavqeeellkelkithvlsvikeelpehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmk

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
. .. |..| . |.. .  ..||  |.. |   .|
keklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP6_pd Subfamily DSP6 69-207 7.5e-33 107.3 In-house 20-156 (158) alignment 
Range on Protein: 69-207
Range on HMM: 20-156/158.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQElyGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||| .|..|  |..|.|....|..     . .|   .... | |..||  | .|...| |  .|||..... ..|.|||.||.|||||| .|.|||
llylGsakdasnlevlkklkikyvlnvtsnlpnkfee..sgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmk

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKE
. ...| .|   |.. .    ||  ||  | . ...|. 
klalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP19_pd Subfamily DSP19 69-205 5.3e-32 105.3 In-house 18-150 (152) alignment 
Range on Protein: 69-205
Range on HMM: 18-150/152.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
|||.||   |.|   |.| .|  |.|.|.|     .... . .|.| |   | .  ||.....|..|||......   |.||| ||||||..| .|.|||
rlylgsqdvaadkeilkekkitHilnvatg....vpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
  ...|.|| ..|.. |  ..||  |.. | .....|
keelsleealelvrearpcikPneGFikqLkeyeael
0048179 (Phosphotyrosine protein) phosphatases II 69-204 7.9e-30 98.8 In-house 10-143 (144) alignment 
Range on Protein: 69-204
Range on HMM: 10-143/144.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQELYgeSITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||  .|.||. |..|||. ..|.. .  ... | .   |..| .  .|..  ||.....|. .||..  |||  |.|||.|||.|. |. .|.|||
glylgslptaldlellkklgittvinlteeyepeflere..giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQ
.....| || ..|.| |  |.||  ..| | ...|.
klglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 69-205 1e-29 98.4 In-house 10-142 (145) alignment 
Range on Protein: 69-205
Range on HMM: 10-142/145.0
RLYIGSAFHAQDLPCLHELGISRIVNMaagsLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||  .|.||. |..||| ...|.     .. . |. . |..| .  .|..  ||.....|. .||..  .||  |.|||.|||.|. |. .|.||.
glylgslptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
.....| || ..|.| |  |.||. ..| |. ....|
llgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 69-205 1.5e-27 90.4 In-house 126-258 (263) alignment 
Range on Protein: 69-205
Range on HMM: 126-258/263.0
RLYIGSAFHAQDLPCLHELGISRIVnMAAGslmTSQELYGESITILLI-TAEDMESYDLSQHFDEVTDFIDKGKEEGaGVFVHCMAGVSRSVTVSVAFLM
.|..|.   |.. . |..||.. |. .| .     . |. .    | |  .||.. .|.||||.|.  ||..|...| ||.||| |||||| |. ...||
klflGgldsannksilkdlgvthil.lava...dfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisylm

KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
|. .... ||   | ..|    ||  |. .|   .|.|
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0041856 (Phosphotyrosine protein) phosphatases II 69-207 3.1e-27 90.7 In-house 25-174 (182) alignment 
Range on Protein: 69-207
Range on HMM: 25-174/182.0
RLYIGSAFH--------------AQDLPCLHELGISRIVNMAaGSLMTSQELYGESITILLITAEDMESYDlsqhFDEVTDFIDKGKEEGAGVFVHCMAG
.||.||  .              |..|. |.||||. |||.. . |   ..|. . |..| .  .|..  |    .||. |||.. .|||  |.|||.||
nlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaG

VSRSVTVSVAFLMKYCNMTLSEAARQVHSNRL--LACPNVTFMRNLFNLQKQLKE
|.|. |. .|.|||.....| || ..| | |     .||  |.. |. |...|  
vgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Slingshot_pd Subfamily Slingshot 69-212 1.6e-26 86.7 In-house 25-164 (169) alignment 
Range on Protein: 69-212
Range on HMM: 25-164/169.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAgslmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
 .|.|| . | .|  |.| |.. |.|..       .. . |... | |   | |. || ....|  .||.| |..|. |.|||  ||||| .. .|. ||
hvylGsewnasnleelkengveyilnvtk....eidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamk

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEKQKK
  ...| || . |...| .. || .|.. | . .  |. .||..
eyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrh
0046846 (Phosphotyrosine protein) phosphatases II 69-206 9.1e-25 82.8 In-house 18-173 (176) alignment 
Range on Protein: 69-206
Range on HMM: 18-173/176.0
RLYIGSAF----------HAQDLPCLHELGISRIVNMAAGS-------LMTSQELYGESITILLITAEDMESYDLsQHFDEVTDFIDKGKEEGAGVFVHC
.|..||..          .|..|  |.||||. .||.               .||....|..| .  .|.   || ....|. .||..  .||  | |||
nlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHC

MAGVSRSVTVSVAFLMKY-CNMTLSEAARQVHSNRL-LACPNVTFMRNLFNLQKQLK
.||..|. |. .|.|... ..... || ..| . |   | ..  ..| |    ..|.
saGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
PTEN_1 69-209 2.5e-23 77.9 In-house 47-195 (196) alignment 
Range on Protein: 69-209
Range on HMM: 47-195/196.0
RLYIGSAFHA-QDLPCLHELGISRIVNMAAGSL-----MTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVT
.||.||. .. .||  |.| ||  .||.. ..       . .| . . .. | .  ||    .||..||.. .||.  .  ..|  | ||| ||..||.|
glyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt

VSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEK
|  |.||.. ..|  || . | . |  ..|| .... | . ...|..||
vvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellaek
0051082 (Phosphotyrosine protein) phosphatases II 69-198 9.4e-22 72.7 In-house 14-146 (151) alignment 
Range on Protein: 69-198
Range on HMM: 14-146/151.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSL--MTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSVAF
.||.... .|..|. |.||||. |||.       .  . |  ..|..| |  .|.  ..|...||.| .|...  .  .  |.|||.||..|. |. ...
glyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvaly

LMKyCNMTLSEAARQVHSNRL-LACPNVTFMRNL
||. ....| || ..... |  . .||  |.  |
lml.lgvsleealeeyrlkrpgvvqpnqqflfql
0036282 (Phosphotyrosine protein) phosphatases II 69-204 2e-21 71.9 In-house 18-168 (174) alignment 
Range on Protein: 69-204
Range on HMM: 18-168/174.0
RLYIGSAFHAqDLPCLHELGISRIVNMAAGSLMT-----------SQELYGESITILLITAEDMESYDLSQhFDEVTDFIDKGKEE--GAGVFVHCMAGV
||..|.. .| ... |.||||. .|..     .            .. |. . |..| .  .|..  |||. ..|. .|...  .|  |  | |||.|||
rliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGv

SRSVTVSVAFLMKYCNM-TLSEAARQVHSNR---LLACPNVTFMRNLFNLQKQ
.|. |. .|.||... . .| .| . |.. |     ....  ..| |  ..|.
gRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_STYXL1_pd Subfamily STYXL1 69-208 6.3e-20 65.0 In-house 18-156 (157) alignment 
Range on Protein: 69-208
Range on HMM: 18-156/157.0
RLYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQELyGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.|   .||.    ..| .   ||..  .    . .  .   .| |. || .  || ....|. .||.| |.||  |.|    |.|||..| .|.|| 
klylGnykqaqnpaikkdlkvkahvnvsmdadkliagv.advakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEE
. ..|| .|  ...  .   .|| .|.  | . .||| .|
skkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0051429 (Phosphotyrosine protein) phosphatases II 69-202 1.2e-17 60.0 In-house 23-221 (272) alignment 
Range on Protein: 69-202
Range on HMM: 23-221/272.0
RLYIGSAF---HAQDLPCLHELGISRIVNMAAGSLMTS--QELYGESITILLITAEDMESYDLSQHF---------------------------------
||| ...     |.|.. |.||||. ||..   . . .   ..| . |..| .  .|.. .. ....                                 
rlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

---------------DEVTDFIDKGKEeGAGVFVHCMAGVSRSVTVSVAFLMKyCNMT--------------LSEAARQVHSNRLLACPNVTFMRNLFNL
               ... ....   . |  | |||.||..|. ||....|.   ...              | || ... . |  | .. .... |.. 
mhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

Q
 
l
subfamily_DSP1_pd Subfamily DSP1 70-211 3.6e-34 112.2 In-house 25-162 (163) alignment 
Range on Protein: 70-211
Range on HMM: 25-162/163.0
LYIGSAFHAQDLPCLHELGISRIVNMAAGslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||. .| .| .|..|||. |.|...      .. . .  .   .. || .. |.|..|.|| .|||. |...  |..|| ||.||| |. .|.||| 
LylGsetvasnleiLkslgitailnvske....ldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEKQK
 ...|.||   |...| .  ||..|...| | .|.|. |..|
krvsleeafdfvkqrRsiisPnagFvlqLlnyekklllelek
subfamily_DSP10_pd Subfamily DSP10 70-209 3.7e-34 111.9 In-house 21-157 (159) alignment 
Range on Protein: 70-209
Range on HMM: 21-157/159.0
LYIGSAFHAQDLPCLHELGISRIVNMAAGSLMTSQElygESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
|..||.  |.||  |..|.|. ..|... . ....|   |...   | ..| .. .|.|.|.|  .||.. ...|. |.|||.||.|||.|| .|.|||.
LflGsekdaadldaldrlnitavlnvttsvPnefee...ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkh

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEK
 |..|..| . |...|    ||..|| .| .. |.|...|
lnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
subfamily_DSP14_pd Subfamily DSP14 70-212 1.2e-32 107.0 In-house 14-151 (157) alignment 
Range on Protein: 70-212
Range on HMM: 14-151/157.0
LYIGsAFHAQDLPCLHELGISRIVNMAAgslmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
|... .  |..   |.. .|. |.|..       ..   ..|  . ...||... .|..|||||.| |.. |..|  . |||.|||||| .. .|.||||
Lfls.gvaalskellkkkkitliinvtv....elpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEKQKK
 ...| || ..|.| | . .||| | ..| .. |.||...  |
eklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvk
DSPc Dual specificity phosphatase, catalytic domain 70-203 1.6e-30 100.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 70-203
Range on HMM: 1-132/133.0
LYIGSAFHAQdLPCLHELGISRIVNMAAGSLMTsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||. .|. |..| .|||. ..|..     . ..   ..|. | |  ||... ..|....|...||.| ...|  |.|||.||.||| |. .|.|||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
 |..|.|| . | ..|   .||. |.| | ....
knlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 70-203 1.6e-30 100.7 In-house 1-132 (133) alignment 
Range on Protein: 70-203
Range on HMM: 1-132/133.0
LYIGSAFHAQdLPCLHELGISRIVNMAAGSLMTsQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||. .|. |..| .|||. ..|..     . ..   ..|. | |  ||... ..|....|...||.| ...|  |.|||.||.||| |. .|.|||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQK
 |..|.|| . | ..|   .||. |.| | ....
knlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 70-211 1.2e-28 94.1 In-house 9-145 (151) alignment 
Range on Protein: 70-211
Range on HMM: 9-145/151.0
LYIGSAFHAQDLPCLHELGISRIVNMAAgslmtSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.|    ..|   |.|  |. |...       ... . . |. ..|.|.|  | .||..|.|  .|| | . .. .|.|||.||||||||. ||.||  
lylgnfrdskdeelLkeknithilsvhd.....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEEKQK
 ..   .| . .. .| .| ||. | | | . .|.  .| .|
telnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrk
subfamily_DSP8_pd Subfamily DSP8 70-208 8.7e-27 87.6 In-house 22-157 (159) alignment 
Range on Protein: 70-208
Range on HMM: 22-157/159.0
LYIGSAFHAQDLPCLHELGISRIVNMAAgSLMTSQELYGESitILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||  .. .  .|..|||| ..|.   | ....||  .   .| .  .|  . .|.. ||. ..|||| |.| . |.||..|| ||| || .|..||.
lylGsqkdvlseellsklgisyvlnasn.scpkleelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

CNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLKEE
 .|.| || | |.. | .  ||. |.  |.. .|.|| .
lemsldeayrfvkekrptispnlnflgqLleyekelkll
0043147 (Phosphotyrosine protein) phosphatases II 70-205 3.6e-26 87.3 In-house 26-160 (172) alignment 
Range on Protein: 70-205
Range on HMM: 26-160/172.0
LYIGSAFHAQDLPCLHELGISRIVNMAaGSLMTSQELYGESITILLITAEDMESYdLSQHFDEVTDFIDK--GKEEGAGVFVHCMAGVSRSVTVSVAFLM
.. ..  .|...  |.||||. |||.  . | . . |. . |..| .  .|.    |.....|. .|||.   ...|  | |||.|||.|..|. .|.||
qgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

KyCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
. ....| || ..| . |  |..|  ..| |  ..|.|
l.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0049260 (Phosphotyrosine protein) phosphatases II 70-205 2.6e-24 81.1 In-house 15-149 (152) alignment 
Range on Protein: 70-205
Range on HMM: 15-149/152.0
LYIGSAFHAQDLPCLHELGISRIVNMAAGSLmTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDK-GKEEGAGVFVHCMAGVSRSVTVSVAFLMK
...|.  .|...  |.||||. ||..   .     .   . |..| .  .|.  .||||..... .||.|  ...|  |.|||.|||.|. |. .|.||.
qgpgpntladfwrmlkelgittivmltelle.lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

yCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
 ....| || ..| . |  |.||  ..| |.. .|.|
.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0040439 (Phosphotyrosine protein) phosphatases II 73-203 8.8e-23 76.6 In-house 39-243 (249) alignment 
Range on Protein: 73-203
Range on HMM: 39-243/249.0
GSAFHAQDL------------------------PCLHELGISRIVNMAAGSLMTSQE---------------------------------------LYGE
..  .|  .                          |.||||. ||..     .  .                                         .||
sdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydge

SITILLITAEDMESYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNL
|.|.| |   |.  ......|... |||.. ..      .|  |.|||.|||.|. |. .|.||     |.....| || ... | |  |..|  ..| |
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

FNLQK
 .. .
yeall
subfamily_STYX_pd Subfamily STYX 74-203 8.7e-14 44.9 In-house 25-155 (166) alignment 
Range on Protein: 74-203
Range on HMM: 25-155/166.0
SAFHAQDLPCLHELGISRIVNMAAGSLM-TSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNM
||     |. |.. ||. || .         .  . ...  |..   |    .. ... .| .|||.  ..|  |.||  ||.||| .. .|..|.   .
saamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetygl

TLSEAARQVHSNRLLACPNVTFMRNLFNLQK
   || . |  .|.   ||  |...| . . 
kyreafayvqerrfcinpnegfvsqlkeyea
0045450 (Phosphotyrosine protein) phosphatases II 82-204 1.5e-20 69.6 In-house 125-302 (307) alignment 
Range on Protein: 82-204
Range on HMM: 125-302/307.0
PCLHELGISRIVNMAAGSLM------------------------TSQELYGESITILLITAEDM-----------------ESYDLSQHFDEVTDFIDKG
  |.|.|.. ||..     .                        .  | . ...|.. .. .|.                   ......|.|. |||.. 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KE------EGAGVFVHCMAGVSRSVTVSVAFLMKYCN--------MTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQ
..      .|  | |||.|||.|. |. .|.||...         ..| || ... . |  |..|  ..| | .. ..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 83-204 1.8e-18 62.3 In-house 105-274 (317) alignment 
Range on Protein: 83-204
Range on HMM: 105-274/317.0
CLHELGISRIVNMAAGS------------------------LMTSQELyGESITILLITAEDM----------------ESYDLSQHFDEVTDFIDKGKE
...|.|.. ||..                             ..| |   ..||.. .. ||.                  ... ...|.. ||... .|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

E----GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQ
     |  | |||.|||.|. |. .|.||     |...... || ... . |  |...  ..| |  .  .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0039614 (Phosphotyrosine protein) phosphatases II 83-205 2.8e-17 58.6 In-house 120-288 (297) alignment 
Range on Protein: 83-205
Range on HMM: 120-288/297.0
CLHELGISRIVNMAAGSLM----------------------TSQELyGESITILLITA-----------------EDMESYDLSQHFDEVTDFIDKGKE-
 ..|.|.. ||..     .                      .. |   . .|.  ..                   |.   .......|. .....  . 
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
  .|  | |||.|||.|. |. .|.||     |...... || ... . |  |...  ..| |... ..|
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0036941 (Phosphotyrosine protein) phosphatases II 84-206 2.2e-17 58.8 In-house 98-277 (297) alignment 
Range on Protein: 84-206
Range on HMM: 98-277/297.0
LHELGISRIVNMAAGSLMT------------SQELYGESITILLITAED-------------------------------MESYDLSQHFDEVTDFIDKG
..|.... ||..     .              ..|. . .|. |.. |                                   ... ...... |||.. 
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

KE------EGAGVFVHCMAGVSRSVTVSVAFLM--------KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQLK
..      .|  | |||.|||.|| |. .|.||        |...... || ... . |  |.... ..| |  .  .| 
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 84-200 2e-14 49.2 In-house 108-271 (278) alignment 
Range on Protein: 84-200
Range on HMM: 108-271/278.0
LHELGISRIVNMAAGSLMT-----------------------------------------SQELYGESITILLITAEDMESY-DLSQHFDEVTDFIDKGK
..|||.. ||..     .                                              . .   .  .   |..   .||...| . ..... .
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

EEGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMRNLFN
 ..  | |||.|||.|. |. ...|.     |.....| || ... . |  |...  ..| |..
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
subfamily_DSP23_pd Subfamily DSP23 84-185 1.4e-06 23.0 In-house 27-125 (148) alignment 
Range on Protein: 84-185
Range on HMM: 27-125/148.0
LHELGISRIVNMAAGSLMTSQELygESITILLITAEDMESYDLSQhFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHS
| .||.  .| ..  .   ..     ..|.  .  .|.    | |  .|    ... .| .  | |||. |  |. |.   .|.|  ... .||  .|  
lldlgvrylvslteegrphveat..pnltlvrlriddyhppaleq.vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

NR
 |
lr
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 89-176 1e-06 19.1 Pfam-A 319-410 (451) alignment 
Range on Protein: 89-176
Range on HMM: 319-410/451.0
ISRIVNMAAGSLMTSQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLS--E
.. .... .  .....|   ..   | .... ..| .|.........||..  ..     ..|.|  |   ||.| .| | .| . . .  .
vdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkk
subfamily_PTEN_pd Subfamily PTEN 91-184 8.2e-07 24.2 In-house 63-154 (184) alignment 
Range on Protein: 91-184
Range on HMM: 63-154/184.0
RIVNMAAGSLMTSQELYGeSITILLITAEDMESYDLS-QHFDEVTDFIDKGKEEgaGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSN
.| |....    |... |  .... .. .   . .|  .  ......... |..   | |||.||  |. .. ||.|.|.. .. .| |......
kiynlrserkydskkfdg.rvavypfdDhnppplelleeivediekwleedkkn..vvvvHCkaGkGRtGvlivayllkslllekaeealelfae
subfamily_Laforin_pd Subfamily Laforin 102-185 3.6e-07 23.2 In-house 67-151 (183) alignment 
Range on Protein: 102-185
Range on HMM: 67-151/183.0
TSQELYG-ESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNR
| . ||  | .. . .  ||. .    . . .   ..    |.|  |.||| ||| || .. . ||.   . .|.    .. ..|
tlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
subfamily_PTPMT1_pd Subfamily PTPMT1 103-186 4.2e-14 47.4 In-house 66-149 (171) alignment 
Range on Protein: 103-186
Range on HMM: 66-149/171.0
SQELYGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRL
..|   . ...| ..  |.      ..  .  .||.| ...|  |.||| || .|| |.  ..|||  .... || . ... | 
teewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk
subfamily_PTPDC1_pd Subfamily PTPDC1 103-187 7e-06 20.6 In-house 75-157 (182) alignment 
Range on Protein: 103-187
Range on HMM: 75-157/182.0
SQELYGESITILLITAEDMESYDLSQHFDEVtDFIDKGKEEGaGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLL
 ..|  . |..  .. .| ..  | . .| |   ..   .||  | ||| ||  |   .  ..|.   ..| ..| . | |.|  
lealmeqgiyvynfgwkDygvasleriLdiv.kvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
0038934 (Phosphotyrosine protein) phosphatases II 104-207 1.7e-15 52.7 In-house 73-178 (194) alignment 
Range on Protein: 104-207
Range on HMM: 73-178/194.0
QELYGESITILLITAEDME---SYDLSQHFDEVTDFIDkGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFN
.|...  |..| .  .|     |... ..| .. |..   . .|  | |||.||..|. |. .|.|.....|.. || . . . |  | ||. ... |. 
eefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

LQKQLKE
  |.|..
rykelrk
0047943 (Phosphotyrosine protein) phosphatases II 107-198 1.4e-11 39.8 In-house 162-264 (273) alignment 
Range on Protein: 107-198
Range on HMM: 162-264/273.0
YGESITILLITAEDMESYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFM
.||| |.  .   .   ..  ...... .||.. ..      ..  | |||.|||.|. |. ...|.     |. .... || ... | |  . ... ..
tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy

RNL
| |
rfl
0046845 (Phosphotyrosine protein) phosphatases II 107-195 2.5e-09 32.4 In-house 161-263 (284) alignment 
Range on Protein: 107-195
Range on HMM: 161-263/284.0
YGESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE------GAGVFVHCMAGVSRSVTVSVAFLMKYC--------NMTLSEAARQVHSNRLLACPNV
 |||.|.  .   .   ..  .... . .|... .|       |  . |||.|||.|. |. .. |....        .... || ... . |  .  ..
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

TFM
  .
eqy
0050432 (Phosphotyrosine protein) phosphatases II 108-194 5.5e-10 34.5 In-house 194-287 (308) alignment 
Range on Protein: 108-194
Range on HMM: 194-287/308.0
GESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTF
|||.|.  .   . . ..  ...... ||... ..   |  . |||.|||.|. |. .. |.     | ..... || ... . |  . ...  
gesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 109-196 7.4e-10 34.2 In-house 180-276 (288) alignment 
Range on Protein: 109-196
Range on HMM: 180-276/288.0
ESITILLITAEDMESYDLSQHFDEVTDFIDKGKEE----GAGVFVHCMAGVSRSVTVSVAFLM-----KYCNMTLSEAARQVHSNRLLACPNVTFMR
||.|.  .   .   ..  ...... ||. . ..     |  | |||.|||.|. |. ...|.     |   ... || ... . |  .....  .|
esrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr
subfamily_DSP11_pd Subfamily DSP11 116-202 8.6e-08 26.3 In-house 87-174 (178) alignment 
Range on Protein: 116-202
Range on HMM: 87-174/178.0
ITAEDMESYDLSQHF-DEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQ
.. ..... .| ..| ..|..|..| |.... . |||  || |.  .   .|.. ...  ..| .. .. |  .     ....| .|.
cpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkle
subfamily_MSG5_pd Subfamily MSG5 128-205 3.5e-11 36.5 In-house 83-160 (165) alignment 
Range on Protein: 128-205
Range on HMM: 83-160/165.0
QHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCNMTLSEAARQVHSNRLLACPNVTFMRNLFNLQKQL
. . ..|  |   . ..  ..|||  |.||| .. ||..||| |..| .|  ...|      |.. .. .|.. .  |
kdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0048567 (Phosphotyrosine protein) phosphatases II 132-200 1.1e-06 23.1 In-house 62-135 (157) alignment 
Range on Protein: 132-200
Range on HMM: 62-135/157.0
EVTDFIDKGKEEGAGVFVHCMAGV---SRSVTVSVAFLMKYCNMTLSEAARQVHSNR--LLACPNVTFMRNLFN
 . .|..  ...|  . ||| ||    .|..|.  ..|......| .|| . .   |  ..  .  ...  |.|
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn