Gene AqueDSP-sf1-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily AqueDSP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP020_AA protein Get Run
AqueP020_AA_90-239 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051429 (Phosphotyrosine protein) phosphatases II 71-234 1e-17 60.1 In-house 4-223 (272) alignment 
Range on Protein: 71-234
Range on HMM: 4-223/272.0
GSIIHANNVPTLxxxxspslvysdangF------RLYVGSII---HANNVPTLQEIGITRIVNMAATDSVATS--SSKSQDFETLLIGASDLKSYDLSQH
...|.|. |...               .      ||| ..      |.....|.| ||. ||..  .. ..    .   .... | .   |   .. ...
sgyiNardvggy...............grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilyg

F------------------------------------------------DEVTDFIDKGKEeGAGVFVHCMAGVSRSVTVSVAFLMKyCGMS--------
.                                                ... ....   . |  | |||.||..|. ||....|.   |.|        
alrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddY

------LSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
      | .| ...|..| .| ..  ... |.. ...
lltnlyleeaveelraqrpgavqteeqylflyealle
0044763 (Phosphotyrosine protein) phosphatases II 88-239 1.4e-34 114.6 In-house 23-174 (178) alignment 
Range on Protein: 88-239
Range on HMM: 23-174/178.0
PSLVYSDangfrLYVGSIIHANNVPTLQEIGITRIVNMAATDSV-----ATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGK-EEGAGVFVHC
.| .. .     ||.||  .|.... |.| ||| |||.. ..            .. ... | |. .| .  ||..||.|...||..   |.|  |.|||
aseilpg.....lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

MAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLqAYPNVRFIKSLLQLEKQLKQKK
.|||.|| |. .|.|||..|.|| .| ..||..|  ..||  ... |...|..|....
saGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0037934 (Phosphotyrosine protein) phosphatases II 88-235 7.3e-24 80.1 In-house 44-241 (243) alignment 
Range on Protein: 88-235
Range on HMM: 44-241/243.0
PslvysdangfRLYVGSI--------IHANNVPTLQEIGITRIVNMAATD----------------------------------------SVAT-SSSKS
|          ||....         ..|...  |.| ||| ||..  ..                                        .    .  . 
p..........rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltr

QDFETLLIGASD----LKSYDLSQHFDEVTDFIDK-----GKEEGAGVFVHCMAGVSRSVTVSVAFLMKYC-GMSLSDAARQVRSHRLQ-AYPNVRFIKS
...  . ..  |        || ...|||..||..        .|  | |||.|||.|. |. .|.||... |..| .| ...|..| . | ..  ... 
lvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrf

LLQLEKQL
| .....|
lyeallel
subfamily_MKPLT_pd Subfamily MKPLT 88-233 1e-22 74.4 In-house 21-158 (164) alignment 
Range on Protein: 88-233
Range on HMM: 21-158/164.0
PSLVYSDangfRLYVGSIIHANNVPTLQEIGITRIVNMAATDSvaTSSSKSqdFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSR
||.|  |    .|| |   ||.|   |... || |||..         .||  .| | .  .|     ||.... ...|. .  . |  |.|||  |.||
psvvled....tlylGnakhatnekvlkdlkithivnvsqekk..dafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksr

SVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEK
| .|.||||.|. |  | .|   ..  |  . ||  |.| | . |.
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 88-233 1e-22 74.4 In-house 21-158 (164) alignment 
Range on Protein: 88-233
Range on HMM: 21-158/164.0
PSLVYSDangfRLYVGSIIHANNVPTLQEIGITRIVNMAATDSvaTSSSKSqdFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSR
||.|  |    .|| |   ||.|   |... || |||..         .||  .| | .  .|     ||.... ...|. .  . |  |.|||  |.||
psvvled....tlylGnakhatnekvlkdlkithivnvsqekk..dafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksr

SVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEK
| .|.||||.|. |  | .|   ..  |  . ||  |.| | . |.
sssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 89-202 1e-07 22.4 Pfam-A 285-404 (451) alignment 
Range on Protein: 89-202
Range on HMM: 285-404/451.0
SLVYSDANGFRLYVGSIIH----ANNVPTLQEIGITRIVNMAATDSVATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEE--GAGVFVHCM
. | .| |  .|..|.| .    .... . .|  .. .... .. .......|..   .| ...| . | .|.........||..  ..     ..|.| 
kavkndknttelvlgkieknlaaekslvakeekevdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlce

AGVSRSVTVSVAFLMKYCGM
 |   ||.| .| | .|   
sGkdlsvgvvlailclyfde
0049772 (Phosphotyrosine protein) phosphatases II 94-238 1.5e-28 95.8 In-house 117-276 (314) alignment 
Range on Protein: 94-238
Range on HMM: 117-276/314.0
DANGFRLYVG-----------------------------SIIHANNVPTLQeigitrivnmaatdSVA--TSSSKSQDFETLLIGASDlKSYDLSQHFDE
. . .|  |.                             .. .| ....|.              ..    .  . . .. | |  .|  | .|...|||
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..............eelydpelferlgikylripvpD.gsaplledfde

VTDFIDKGkEEGAGVFVHCMAGVSRSVT-VSVAFLMKYCGMSLSDAARQVRSHRLqAYPNVRFIKSLLQLEKQLKQK
. .||..  ..|  |.|||.||..|. | | .|.|||..|.|| .| ..||. |  ..|| .||..|.|.|..|...
flefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefileal
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 95-239 1.6e-91 296.9 In-house 1-145 (145) alignment 
Range on Protein: 95-239
Range on HMM: 1-145/145.0
ANGFRLYVGSIIHANNVPTLQEIGITRIVNMAATDSVATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVA
||||||||||..|||.||||||.||.|||||||...||....||...|.|||.|.||.||||||||||||||||||||||||||||||||||||||||||
angfrlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsva

FLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQKK
||||||.|.||.|||||||.||.|||||.|.|.||.||||||..|
flmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkeek
0042113 (Phosphotyrosine protein) phosphatases II 97-235 6.2e-23 76.9 In-house 51-242 (245) alignment 
Range on Protein: 97-235
Range on HMM: 51-242/245.0
GFRLYVGSIIHANNVP----TLQEIGITRIVNMAATDSVA------------------------------------------TSSSKSQDFETLLIGASD
  ......  ....|.     |.| ||| ||..  ..                                              .. . ...  . ..  |
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

LKSYDLSQHFDEVTDFIDKGKE--EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQL
 .  ||....... .|..|  .  ..  |.|||.|||.|. |. .|.||     |..|.|| .| ...||.| .| ..  ... | .....|
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 97-225 1.2e-21 72.3 In-house 13-143 (151) alignment 
Range on Protein: 97-225
Range on HMM: 13-143/151.0
GFrLYVGSIIHANNVPTLQEIGITRIVNMAATDSVATS--SSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSV
|. ||...  .| ....|.| ||. |||.  ..  ..     .....| | |   | . ..|...||.| .|...  .  .  |.|||.||..|. |. .
gg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

AFLMKyCGMSLSDAARQVRSHRL-QAYPNVRFI
..||. .|.|| .| ...|..|    .||  |.
lylml.lgvsleealeeyrlkrpgvvqpnqqfl
0045098 (Phosphotyrosine protein) phosphatases II 98-237 2.2e-24 81.7 In-house 27-273 (278) alignment 
Range on Protein: 98-237
Range on HMM: 27-273/278.0
FRLYVGSII-----------------------------------------HANNVPTLQEIGITRIVNMAATDSVA------------------------
. ||.|..                                          .|..  .|.| ||| ||...     .                        
palylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtll

-----------------T----SSSKSQDFETLLI-GASDLKSYDLS--QHFDEVTDFIDKGKE--------------EGAGVFVHCMAGVSRSVTVSVA
                 .    .. .|  .. | . .  |  . .|.  ..|.|...||..  .              .|  |.|||.|||.|. |. .|
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

FLMKYC---GMSLSDAARQVRSHRLQ-AYPNVRFIKSLLQLEKQLKQ
.||...   |..| .| ...||.| . | .|  ... | ... .| .
ylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 98-236 6e-21 68.4 In-house 8-153 (154) alignment 
Range on Protein: 98-236
Range on HMM: 8-153/154.0
FRLYVGSIIHANNVPTLQEIGITRIVNM-AATDSVATSS-SKSQD---FETLLIGASDLKSYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVT
  ||..|   | |   ||.  |. |.|.   .. . |   |  .|   .| | .   |   .|. ...| . .|||.     |  .|.||. .||||| .
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLK
. ...||.   .||| |   ... | .  ||  |.| | . ||.|.
llisylmdklkislslalellkdsryiikPnqGflkqleifekell
PTPc_motif_SM00404 99-233 1.9e-36 120.0 In-house 8-139 (140) alignment 
Range on Protein: 99-233
Range on HMM: 8-139/140.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATDSVAtssSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||. .|.| . |...||| ..|.. . |.    .. ..|. | |  .| .. .||...|.|.|||.. ...|  |.|||.||||||.|. .|.||.
hlylgskskaqnpallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEK
| ..||..| . |.. | .  ||..|...|...||
yrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP6_pd Subfamily DSP6 99-238 1.4e-34 112.9 In-house 20-157 (158) alignment 
Range on Protein: 99-238
Range on HMM: 20-157/158.0
RLYVGSIIHANNVPTLQEIGITRIVNMaaTDSVATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||  .|.|. .|.. .| ...|.  |  .     .|.... | | ..|  | .|...| |  .|||..... ..|.|||.||.|||||| .|.|||
llylGsakdasnlevlkklkikyvlnv..tsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmk

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
.  .|| ||   |.... .  ||  |.. ||. |..|. .
klalslndaydlvkkrksnisPnfnfmgqlldferslrls
subfamily_DSP12_pd Subfamily DSP12 99-233 1.7e-33 110.2 In-house 8-141 (155) alignment 
Range on Protein: 99-233
Range on HMM: 8-141/155.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATDSvATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.|.. .... ..|.|..||... .. ..   . . | .  .|. | . |  . |. .|.||..|||... ||.  |.|||.||||||||. .|.|||
glylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmk

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEK
. ..||..| . |.. . ...||  |.. |   ||
keklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP3_pd Subfamily DSP3 99-239 1.8e-33 109.5 In-house 17-161 (162) alignment 
Range on Protein: 99-239
Range on HMM: 17-161/162.0
RLYVGSIIHANNVPTLQEIGITRIVNMAAT--DSVATSSSKSQD--FETLLIGASDLKSYDLSQHFDEVTDFIDKGKEE-GAGVFVHCMAGVSRSVTVSV
.||||    |..   |...||| ..| |..   .| | ..  .|  .. | . ..| .. |||..|.....|||.  ..  . |.|||..||||| |. .
klyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvl

AFLMKYCGMSLSDAARQVRSHRlQAYPNVRFIKSLLQLEKQLKQKK
|.|| .  |.| .| |.||..| . .||  |.| | .|...||.||
ayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrkk
subfamily_DSP19_pd Subfamily DSP19 99-235 3.2e-32 106.0 In-house 18-150 (152) alignment 
Range on Protein: 99-235
Range on HMM: 18-150/152.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATdsvaTSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
|||.||.  |..  .|.| .|| |.|.|.     .    ..||..| |   ||.  ||.....|..|||......   |.||| ||||||..| .|.|||
rlylgsqdvaadkeilkekkitHilnvatg....vpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQL
   .||..| ..||..|  . ||  ||| | ..|..|
keelsleealelvrearpcikPneGFikqLkeyeael
0048076 (Phosphotyrosine protein) phosphatases II 99-235 5.8e-31 102.5 In-house 10-142 (145) alignment 
Range on Protein: 99-235
Range on HMM: 10-142/145.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATDSVATssskSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||. .|.....|.. |||...|.. . .  .     .... | ..  |    ||.....|. .||..  .||  |.|||.|||.|. |. .|.||.
glylgslptaldlellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQL
..|.|| .| ..|||.| .| ||. ... |...|..|
llgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 99-235 6.6e-31 102.3 In-house 10-144 (144) alignment 
Range on Protein: 99-235
Range on HMM: 10-144/144.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATdsVATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
.||.||. .|.....|.. ||| ..|.. .      . . . .. | ..  |    ||.....|. .||..  |||  |.|||.|||.|. |. .|.|||
glylgslptaldlellkklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQL
..|.|| .| ..|||.| .|.||  ... ||..||.|
klglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 99-236 3.3e-30 99.1 In-house 126-259 (263) alignment 
Range on Protein: 99-236
Range on HMM: 126-259/263.0
RLYVGSIIHANNVPTLQEIGITRI-VNMAATDSVAtssskSQDFETLLI-GASDLKSYDLSQHFDEVTDFIDKGKEEGaGVFVHCMAGVSRSVTVSVAFL
.|..|.   ||| . |.. |.| | . .|  . .       . |  | |  . | . .|.||||.|.  ||..|...| ||.||| |||||| |. ...|
klflGgldsannksilkdlgvthillavadfePlf.....PklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisyl

MKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLK
||.  . . .|   | ..| . .||  |.. |.. ||.| 
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0041856 (Phosphotyrosine protein) phosphatases II 99-236 1.8e-26 88.2 In-house 25-173 (182) alignment 
Range on Protein: 99-236
Range on HMM: 25-173/182.0
RLYVGSIIH--------------ANNVPTLQEIGITRIVNMAaTDSVATSSSKSQDFETLLIGASDLKSYDlsqhFDEVTDFIDKGKEEGAGVFVHCMAG
.||.||  .              |.....|.| ||| |||..  .    .  . . .. | ..  |    |    .||. |||.. .|||  |.|||.||
nlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaG

VSRSVTVSVAFLMKYCGMSLSDAARQVRSHRL--QAYPNVRFIKSLLQLEKQLK
|.|. |. .|.|||..|.|| .| ..|||.|     .||  |.  |. ||..| 
vgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 99-234 8.1e-26 84.3 In-house 14-146 (148) alignment 
Range on Protein: 99-234
Range on HMM: 14-146/148.0
RLYVGSIIHANNVPTLQEIGITRIVNMAATDSVATsssKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
 |..||  .| .. .|...|.|||||...    |      .  | | .  .| . .|||. |.....|..| |.||  | ||.  |||||  .....|..
fLFlGskksaadlealkalgvtrivnatkerdnal...dqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlid

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
.  .|| .|.  |.| |    ||  |.| | .||..
fkrvslkealalvkskrryvdpnlgfLkqLaeleqa
PTEN_1 99-238 2.5e-25 84.4 In-house 47-194 (196) alignment 
Range on Protein: 99-238
Range on HMM: 47-194/196.0
RLYVGSIIHA-NNVPTLQEIGITRIVNMAATDSV-----ATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGK--EEGAGVFVHCMAGVSRSVT
.||.||. .. ... .|.| ||| .||..  .         .. . ...| | ..  |    .||..||.. .||.  .  ..|  | ||| ||..||.|
glyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt

VSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
|  |.||.. ...  .| . ||..| .. || .. . ||. ...|...
vvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0046846 (Phosphotyrosine protein) phosphatases II 99-237 3.1e-25 84.3 In-house 18-174 (176) alignment 
Range on Protein: 99-237
Range on HMM: 18-174/176.0
RLYVGSII----------HANNVPTLQEIGITRIVNMAATD-------SVATSSSKSQDFETLLIGASDLKSYDLsQHFDEVTDFIDKGKEEGAGVFVHC
.|..||            .|...  |.| ||| .||.               .  .. ... | ..  |    || ....|. .||..  .||  | |||
nlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHC

MAGVSRSVTVSVAFLMKY-CGMSLSDAARQVRSHRL-QAYPNVRFIKSLLQLEKQLKQ
.||..|. |. .|.|... .|.|. .| ..||..|  .| ..  ... | . |..|..
saGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_Slingshot_pd Subfamily Slingshot 99-239 6.3e-24 78.3 In-house 25-161 (169) alignment 
Range on Protein: 99-239
Range on HMM: 25-161/169.0
RLYVGSIIHANNVPTLQEIGITRIVNMAAtdSVatSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMK
 .|.||   | |.  |.| |.. |.|..    .   .  ...|| | |   | .. || ....|  .||.| |..|. |.|||  ||||| .. .|. ||
hvylGsewnasnleelkengveyilnvtk..ei..dnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamk

YCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQKK
  |.|| .| . |...|  . ||  |.| | . |  |. .|
eyglsleealeyvkerrsvikPnkgflkqleeyeGileask
0036282 (Phosphotyrosine protein) phosphatases II 99-236 4.2e-22 74.1 In-house 18-170 (174) alignment 
Range on Protein: 99-236
Range on HMM: 18-170/174.0
RLYVGSIIHAnNVPTLQEIGITRIVNMAATDSVA-----------TSSSKSQDFETLLIGASDLKSYDLSQhFDEVTDFIDKGKEE--GAGVFVHCMAGV
||..|.  .| ... |.| ||| .|..                   .. .  ... | ..  |    |||. ..|. .|...  .|  |  | |||.|||
rliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGv

SRSVTVSVAFLMKYCGM-SLSDAARQVRSHR---LQAYPNVRFIKSLLQLEKQLK
.|. |. .|.||..... || || . ||. |    .....  ... | ..||.|.
gRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
subfamily_STYXL1_pd Subfamily STYXL1 99-237 5.9e-20 65.1 In-house 18-155 (157) alignment 
Range on Protein: 99-237
Range on HMM: 18-155/157.0
RLYVGSIIHANNVPTLQEIGITRIVNMAAT-DSvaTSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLM
.||.|   .| |    ... .   ||..   |     .. ..  . | |  .| .  || ....|. .||.| |.||  |.|    |.|||..| .|.||
klylGnykqaqnpaikkdlkvkahvnvsmdadk..liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylm

KYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQ
 .  ..| .|  ...  .    ||  |.. | . |||| .
yskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
subfamily_DSP10_pd Subfamily DSP10 100-239 8.8e-34 110.7 In-house 21-157 (159) alignment 
Range on Protein: 100-239
Range on HMM: 21-157/159.0
LYVGSIIHANNVPTLQEIGITRIVNMaaTDSVATSSSKsQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
|..||   |..  .|.. .|| ..|.  | || . ... ....   | .|| .. .|.|.|.|  .||.. ...|. |.|||.||.|||.|| .|.|||.
LflGsekdaadldaldrlnitavlnv..ttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkh

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQKK
 ..||.|| . |.. |    ||. |.  ||..||.|...|
lnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
subfamily_DSP1_pd Subfamily DSP1 100-238 8.3e-33 107.8 In-house 25-159 (163) alignment 
Range on Protein: 100-238
Range on HMM: 25-159/163.0
LYVGSIIHANNVPTLQEIGITRIVNMAATdsVATSSSKsqDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.|| ..| |. .|.. ||| |.|....  .     .   ||   .  .| .. |.|..|.|| .|||. |...  |..|| ||.||| |. .|.||| 
LylGsetvasnleiLkslgitailnvske..ldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
  .||..|   |...|    ||. |...||. ||.|...
krvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP14_pd Subfamily DSP14 100-239 2.4e-32 106.0 In-house 14-148 (157) alignment 
Range on Protein: 100-239
Range on HMM: 14-148/157.0
LYVGsIIHANNVPTLQEIGITRIVNMAAtdsvATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
|...    |..  .|.. .|| |.|..      ... | .|.|.. . ..| .. .|..|||||.| |.. |..|  . |||.|||||| .. .|.||||
Lfls.gvaalskellkkkkitliinvtv....elpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQKK
  .|| .| ..|.|.| .  ||| | | | ..||.||.|.
eklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
DSPc Dual specificity phosphatase, catalytic domain 100-234 3.1e-31 103.0 Pfam-A 1-133 (133) alignment 
Range on Protein: 100-234
Range on HMM: 1-133/133.0
LYVGSIIHANnVPTLQEIGITRIVNMAATDSVAtSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||  .|.  . |...||| ..|.. . . .  ..| ...| | |   | .. ..|....|...||.| ...|  |.|||.||.||| |. .|.|||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
 ..||..| . |.. | .  ||..|...||..|..
knlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 100-234 3.1e-31 103.0 In-house 1-133 (133) alignment 
Range on Protein: 100-234
Range on HMM: 1-133/133.0
LYVGSIIHANnVPTLQEIGITRIVNMAATDSVAtSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||  .|.  . |...||| ..|.. . . .  ..| ...| | |   | .. ..|....|...||.| ...|  |.|||.||.||| |. .|.|||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
 ..||..| . |.. | .  ||..|...||..|..
knlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP15_pd Subfamily DSP15 100-236 1.7e-28 93.6 In-house 9-140 (151) alignment 
Range on Protein: 100-236
Range on HMM: 9-140/151.0
LYVGSIIHANNVPTLQEIGITRIVNMAAtdsvaTSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.| .. ...   |.|  || |...        .    .|.| ..| |||  | .||..|.|  .|| | . .. .|.|||.||||||||. ||.||  
lylgnfrdskdeelLkeknithilsvhd.....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLK
  ..  || . .. .|  | ||. | . | . ||.  
telnwrdalevikaaRsvanPnfGfkrqlkeyektkl
subfamily_DSP8_pd Subfamily DSP8 100-238 2.2e-27 89.5 In-house 22-157 (159) alignment 
Range on Protein: 100-238
Range on HMM: 22-157/159.0
LYVGSIIHANNVPTLQEIGITRIVNMAATDSVATSSSKSQdfeTLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKY
||.||  .. .  .|...||. ..|.  ..      ..|.    | .   |  . .|.. ||. ..|||| |.| . |.||..|| ||| || .|..||.
lylGsqkdvlseellsklgisyvlnasnscpkleelkesk...flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

CGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
  ||| .| | |...|    ||. |.. ||. ||.||..
lemsldeayrfvkekrptispnlnflgqLleyekelkll
0043147 (Phosphotyrosine protein) phosphatases II 100-237 3.8e-27 90.5 In-house 26-162 (172) alignment 
Range on Protein: 100-237
Range on HMM: 26-162/172.0
LYVGSIIHANNVPTLQEIGITRIVNMAaTDSVATSSSKSQDFETLLIGASDLKSYdLSQHFDEVTDFIDK--GKEEGAGVFVHCMAGVSRSVTVSVAFLM
.....  .| ..  |.| ||| |||.  .  . ..  . .... | ..  |     |.....|. .|||.   ...|  | |||.|||.|..|. .|.||
qgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

KyCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQ
. .|.|| .| ..||..| .| .|  ... |...||.|..
l.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
0040439 (Phosphotyrosine protein) phosphatases II 100-235 7.9e-26 86.6 In-house 36-245 (249) alignment 
Range on Protein: 100-235
Range on HMM: 36-245/249.0
LYVGSIIHANNVPT------------------------LQEIGITRIVNMAATDSVA---------------------------------------TSSS
|. .. |.|. ...                        |.| ||| ||..  ..                                          | . 
lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnly

KSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFI
...... | |   |.  ......|... |||.. ..      .|  |.|||.|||.|. |. .|.||     |..|..| .| ...||.| .| .|  ..
dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy

KSLLQLEKQL
. |......|
rflyeallel
0049260 (Phosphotyrosine protein) phosphatases II 100-236 4e-25 83.7 In-house 15-150 (152) alignment 
Range on Protein: 100-236
Range on HMM: 15-150/152.0
LYVGSIIHANNVPTLQEIGITRIVNMAATDSvATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDK-GKEEGAGVFVHCMAGVSRSVTVSVAFLMK
...|.  .|...  |.| ||| ||..   .   .     | .. | .   |   .||||..... .||.|  ...|  |.|||.|||.|. |. .|.||.
qgpgpntladfwrmlkelgittivmltelle.lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

yCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLK
 .|.|| .| ..||..| .|.||  ... |.. ||.||
.lgvsleeavalvrekRpgavpnpgqlrflyefekllk
0043336 (Phosphotyrosine protein) phosphatases II 102-233 1.5e-17 59.4 In-house 66-274 (278) alignment 
Range on Protein: 102-233
Range on HMM: 66-274/278.0
V------GSIIHANNVPTLQ------------------------EIGITRIVNMAATDSVA---------------------------------------
.       . |.|. |.. .                        | |.| ||..   .                                          
llggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevt

--TSSSKSQDFETLLIGASDLKSY-DLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRF
   .. . .      .|  | .   .||...| . ..... . ..  | |||.|||.|. |. ...|.     |..|..| .| ...|..| .| ..  .
nlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq

IKSLLQLEK
.. | ....
yrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 105-239 3.6e-20 67.9 In-house 65-280 (297) alignment 
Range on Protein: 105-239
Range on HMM: 65-280/297.0
IIHANNVPTLQ------------------------EIGITRIVNMAATDSVAT------------SSSKSQDFETLLIGASD------------------
 |.|. |.. .                        | ..| ||..   ..               .| .  ||   |.. .                   
YinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn

-------------LKSYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM--------KYCGMSLSDAARQVRSHRLQAYPNVR
                ... ...... |||.. ..      .|  | |||.|||.|| |. .|.||        |..|... .| ...|..| .| ... 
gesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

FIKSLLQLEKQLKQKK
. . | ... .| .||
qyrflyeallellkkk
0045450 (Phosphotyrosine protein) phosphatases II 106-236 2.4e-24 82.1 In-house 87-304 (307) alignment 
Range on Protein: 106-236
Range on HMM: 87-304/307.0
IHANNV--------------------------------PTLQEIGITRIVNMAATDSV------------------------ATSSSKSQDFETLLIGAS
|.|. |                                  |.| |.| ||..  ..                           .| .. ...  . .  .
iNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevt

DL-----------------KSYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLMKYCG--------MSLSDAARQVRSHRLQA
||                   ......|.|. |||.. ..      .|  | |||.|||.|. |. .|.||....        ..| .| ...|..| .|
dldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpga

YPNVRFIKSLLQLEKQLK
 .|  ... | .....| 
vqnpeqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 106-236 1.9e-21 72.1 In-house 74-276 (317) alignment 
Range on Protein: 106-236
Range on HMM: 74-276/317.0
IHANNVPTLQ------------------------EIGITRIVNMAATDSVA-----------------------TSSSKSQDFETLLIGASDL-------
|.|. |.. .                        | |.| ||..  ..                          .|  . .... . .  .||       
InAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrt

---------KSYDLSQHFDEVTDFIDKGKEE----GAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEK
           ... ...|.. ||... .|     |  | |||.|||.|. |. .|.||     |..|... .| ...|..| .| ..  ... | ... 
vthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall

QLK
.. 
eyl
0039614 (Phosphotyrosine protein) phosphatases II 106-238 5e-20 67.6 In-house 88-291 (297) alignment 
Range on Protein: 106-238
Range on HMM: 88-291/297.0
IHANNVPT-------------------------LQEIGITRIVNMAATDSVA---------------------TSSSKSQDFE-----------------
|.|. |..                         ..| |.| ||..  ..                        ..  . ...                  
inAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvth

TLLIGASDLKSYDLSQHFDEVTDFIDKGKE---EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
 . .|  | .  .......|. .....  .   .|  | |||.|||.|. |. .|.||     |..|... .| ...|..| .| ..  ... | .....
fqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

LKQK
| ..
llkr
subfamily_STYX_pd Subfamily STYX 108-233 7.3e-17 54.9 In-house 29-155 (166) alignment 
Range on Protein: 108-233
Range on HMM: 29-155/166.0
ANNVPTLQEIGITRIVNMAA-TDSVATSSSKSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSD
   ...|.. ||| || .    ..        ..|  |..  .|    .. ... .| .|||.  ..|  |.||  ||.||| .. .|..|.  |.   .
ksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyre

AARQVRSHRLQAYPNVRFIKSLLQLEK
| . |. .|.   ||  |.. | . | 
afayvqerrfcinpnegfvsqlkeyea
subfamily_DSP23_pd Subfamily DSP23 114-218 4.7e-08 27.8 In-house 27-128 (148) alignment 
Range on Protein: 114-218
Range on HMM: 27-128/148.0
LQEIGITRIVNMaaTDSVATSSSKSQDFETLLIGASDLKSYDLSQhFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRS
| . |.  .| .  |.     .  . .     ..  | .   | |  .|    ... .| .  | |||. |  |. |.   .|.|  ... ..|  .|| 
lldlgvrylvsl..teegrphveatpnltlvrlriddyhppaleq.vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

HRLQA
 |  .
lrpgs
subfamily_PTPMT1_pd Subfamily PTPMT1 116-235 6.6e-14 46.7 In-house 44-168 (171) alignment 
Range on Protein: 116-235
Range on HMM: 44-168/171.0
EIGITRIVNMAATDSVATSSSKSQDFETLLIGASDLKSYDLS-----QHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQ
.  . ..|..     . . .  ..... | .    |.  |       ..  .  .||.| ...|  |.||| || .|| |.  ..|||   .|. .| . 
kenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlka

VRSHRLQAYPNVRFIKSLLQLEKQL
... | .   . .  | | . |..|
lkkkRkiirlakkqwkalqeyeekl
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 137-207 2.3e-06 20.3 In-house 29-99 (128) alignment 
Range on Protein: 137-207
Range on HMM: 29-99/128.0
KSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDA
  .| .   .  || .. .| . . .  . .   .|    ..|||  |. |.  |  .. ||| | .| .|
peddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkka
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 137-207 2.3e-06 20.4 In-house 28-98 (128) alignment 
Range on Protein: 137-207
Range on HMM: 28-98/128.0
KSQDFETLLIGASDLKSYDLSQHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDA
  .| .   .  || .. .| . . .  . .   .|    ..|||  |. |.  |  .. ||| | .| .|
peddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkka
subfamily_DSP11_pd Subfamily DSP11 140-234 3.8e-09 30.7 In-house 81-176 (178) alignment 
Range on Protein: 140-234
Range on HMM: 81-176/178.0
DFETLLIGASDLKSYDLSQHF-DEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQ
 .. | .   .... .| ..| ..|..|..| |.... . |||  || |.  .   .|.. .|.. .|| ..  . |  .     ..|.| .|||.
kylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekd
subfamily_PTPDC1_pd Subfamily PTPDC1 145-238 3.6e-06 21.5 In-house 87-178 (182) alignment 
Range on Protein: 145-238
Range on HMM: 87-178/182.0
LIGASDLKSYDLSQHFDeVTDFIDKGKEEGaGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
 .| .| ..  | . .| .   ..   .||  | ||| ||  |   .  ..|.    .. ..| . |||.| ..      .. . . .. |...
nfgwkDygvasleriLd.ivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflipl
0047943 (Phosphotyrosine protein) phosphatases II 150-230 9.5e-13 43.7 In-house 175-266 (273) alignment 
Range on Protein: 150-230
Range on HMM: 175-266/273.0
DLKSYDLSQHFDEVTDFIDKGKE------EGAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQ
.   ..  ...... .||.. ..      ..  | |||.|||.|. |. ...|.     |. |... .| ...||.|  . ... ... | .
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 153-226 2.2e-11 39.1 In-house 209-289 (308) alignment 
Range on Protein: 153-226
Range on HMM: 209-289/308.0
SYDLSQHFDEVTDFIDKGKEE--GAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFIK
 ..  ...... ||... ..   |  . |||.|||.|. |. .. |.     | .|... .| ...|..| .. ...   .
dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
0051299 (Phosphotyrosine protein) phosphatases II 153-225 3e-11 38.8 In-house 194-275 (288) alignment 
Range on Protein: 153-225
Range on HMM: 194-275/288.0
SYDLSQHFDEVTDFIDKGKEE----GAGVFVHCMAGVSRSVTVSVAFLM-----KYCGMSLSDAARQVRSHRLQAYPNVRFI
 ..  ...... ||. . ..     |  | |||.|||.|. |. ...|.     |  |... .| ...|..| .. ...  .
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
subfamily_MSG5_pd Subfamily MSG5 158-238 2.2e-13 43.6 In-house 83-163 (165) alignment 
Range on Protein: 158-238
Range on HMM: 83-163/165.0
QHFDEVTDFIDKGKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLKQK
. . ..|  |   . ..  ..|||  |.||| .. ||..||| ..|| ||  ...|   .  |.. .|  |.. |  |..|
kdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
0046845 (Phosphotyrosine protein) phosphatases II 158-228 1e-10 37.0 In-house 182-266 (284) alignment 
Range on Protein: 158-228
Range on HMM: 182-266/284.0
QHFDEVTDFIDKGKEE------GAGVFVHCMAGVSRSVTVSVAFLMKYC--------GMSLSDAARQVRSHRLQAYPNVRFIKSL
.... . .|... .|       |  . |||.|||.|. |. .. |....        |... .| ...|..| ..  ..  .. .
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0038934 (Phosphotyrosine protein) phosphatases II 159-236 5e-17 57.6 In-house 102-177 (194) alignment 
Range on Protein: 159-236
Range on HMM: 102-177/194.0
HFDEVTDFIDkgKEEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVRFIKSLLQLEKQLK
 .| | .|..  . .|  | |||.||..|. |. .|.|....|||. .| . .|. |  |.||. ... ||.  |.|.
fldlvdefln..edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
PTPc_DSPc_SM00012 161-218 8.8e-06 21.2 In-house 27-89 (105) alignment 
Range on Protein: 161-218
Range on HMM: 27-89/105.0
DEVTDFIDKGKEeGAGVFVHCMAGVSRSVTVSVAFLMKYC----G--MSLSDAARQVRSHRLQA
..| ..  | .. .. | ||| |||.|. |. .. ..          .....  ...|..| ..
ravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgm
0048567 (Phosphotyrosine protein) phosphatases II 162-215 2.6e-06 21.9 In-house 62-118 (157) alignment 
Range on Protein: 162-215
Range on HMM: 62-118/157.0
EVTDFIDKGKEEGAGVFVHCMAGV---SRSVTVSVAFLMKYCGMSLSDAARQVRSHR
 . .|..  ...|  . ||| ||    .|..|.  ..|....|.. ..| . .|  |
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_Laforin_pd Subfamily Laforin 172-223 8.6e-07 22.0 In-house 108-159 (183) alignment 
Range on Protein: 172-223
Range on HMM: 108-159/183.0
EEGAGVFVHCMAGVSRSVTVSVAFLMKYCGMSLSDAARQVRSHRLQAYPNVR
|.|  |.||| ||| || .. . ||.   | ||.    .. ..|  .| . .
ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyidee
subfamily_PRL_pd Subfamily PRL 172-227 2.9e-06 21.4 In-house 88-141 (151) alignment 
Range on Protein: 172-227
Range on HMM: 88-141/151.0
EEGAGVFVHCMAGVSRSvTVSVAFLMKYCGMSLSDAARQVRSHRLQAYpNVRFIKS
| .. | |||.||. |.  | ||. .  .||.  || . .|..|  |  | . .| 
epkstvavhcvaGlGra.PvlvalalieaGmkyedavefirekrrgai.nskqlkf