Gene STYXL1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYXL1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP021_AA protein Get Run
AqueP021_AA_150-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
GldH_lipo GldH lipoprotein 33-67 7.9e-06 12.6 Pfam-A 33-70 (131) alignment 
Range on Protein: 33-67
Range on HMM: 33-70/131.0
SNYLLILDVRNRKDYEHSHITLAKHIEEVK---EADTG
..| | | .||...|..| ..|  ...  |   ..|| 
gkynlflnlRnnneYpysnlfLivelkspkgkkktdtl
Rhodanese Rhodanese-like domain 36-129 1.6e-10 33.5 Pfam-A 14-112 (113) alignment 
Range on Protein: 36-129
Range on HMM: 14-112/113.0
LLILDVRNRKDYEHSHITLAKHIEE-------VKEADTGNSKYRTPFGADVSTVLHCVVYDgKTVSLIEDNSAIRLATELAENGSKnPVLVLKGGYERFS
...||||. ..|...||. | ...            .  ....    | ...   . |||. ..    .   |..|| .|.|.| |  | ||.||.| ..
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc.rsgnrsggaaalllalilkelgyk.nvyvLdGGfeawk

A
|
a
subfamily_MKPLT_pd Subfamily MKPLT 133-291 1.7e-28 93.2 In-house 1-159 (164) alignment 
Range on Protein: 133-291
Range on HMM: 1-159/164.0
FLRTQKILYTPKELEHLPHYPSEILPHFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSE
|| |.. ..  ..  ..  ||| .|.. ||||.  || |  .. |.||.  .||| .  .|.|..|.   |.|.|... .| . .| .  |. .  .   
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGG

TVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.|||  ..| |||..   |.|| .|    | | .|... |  |.| . |. || ..|..
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 133-291 1.7e-28 93.2 In-house 1-159 (164) alignment 
Range on Protein: 133-291
Range on HMM: 1-159/164.0
FLRTQKILYTPKELEHLPHYPSEILPHFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSE
|| |.. ..  ..  ..  ||| .|.. ||||.  || |  .. |.||.  .||| .  .|.|..|.   |.|.|... .| . .| .  |. .  .   
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGG

TVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.|||  ..| |||..   |.|| .|    | | .|... |  |.| . |. || ..|..
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_STYXL1_pd Subfamily STYXL1 143-294 6.8e-73 237.1 In-house 1-155 (157) alignment 
Range on Protein: 143-294
Range on HMM: 1-155/157.0
PKELEHLPHYPSEILPHFLYLGDERHAYNPLLSYDIKIKGHINVSSD---LYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGN
|.||..|..||.|.||..||||....|.|| ...|.|.|.|.|||.|   |...........|..|.|...|.||||..|...|||...|..|.||||.|
preldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsn

KGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKMQSE
||.||||....|||.|.|....|.|..|...|..|||| ..||.||.||||....
kGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
0044763 (Phosphotyrosine protein) phosphatases II 145-291 4.4e-30 100.0 In-house 15-169 (178) alignment 
Range on Protein: 145-291
Range on HMM: 15-169/178.0
ELEHLPHYPSEILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPET---------VNEVHVDVQDVPQANLLERFEEVCSFIESYR-KKSETV
..   ....|||||. ||||.  .| .. | .. .|.  .|....|.   ...         .. .|. . | .  .||| |.|.. |||... .| ..|
lersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpv

LVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPnVKPLKSFVDQLKEWEKM
||  . |..||.|||||||... ...   |....|..|| . |  ... ||.|.|..
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP1_pd Subfamily DSP1 146-292 7.1e-29 95.0 In-house 9-156 (163) alignment 
Range on Protein: 146-292
Range on HMM: 9-156/163.0
LEHLPHY-PSEILPHFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSR
|..|. | |.|..  ||||| | .| |  .  . .|   .|||..|  ..... .  .. ..| |.|.. . ||||  ||.. .||   ||.  . |.||
ldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisR

SATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKMQ
|.||. |||.  |... . | |.... |. ..|  .|| ||...|| .
sstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0041856 (Phosphotyrosine protein) phosphatases II 146-292 2.5e-21 71.5 In-house 17-172 (182) alignment 
Range on Protein: 146-292
Range on HMM: 17-172/182.0
LehlphYPSEILPHfLYLGDERH--------------AYNPLLSYDIKIKGHINVSsdLYSAWPETV-----NEVHVDVQDVPQANllerFEEVCSFIES
.     ....|... ||||. ..              | .  . .. .|.  .|..   .  ||| .     . ... . | .  .    ..|...||| 
r.....dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfiee

YRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRP--NVKPLKSFVDQLKEWEKMQ
 ......|||  . |..|..|||||||.......   |....|..||   . |   |. ||...|...
vleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_DSP10_pd Subfamily DSP10 149-291 1.2e-28 94.0 In-house 10-152 (159) alignment 
Range on Protein: 149-291
Range on HMM: 10-152/159.0
LPHYPSEILPhFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPE-TVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSAT
  .  |..|| ||.||.|. | .  .    .|.  .|| ...   . | ...  ...|.|  . || ..|||   |||  |||...|||  . |.|||||
etapasqvlp.fLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

LVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.| |||....|.. . | ......|| . |  .|. ||.|.|| 
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 149-291 4.2e-25 82.0 In-house 3-146 (148) alignment 
Range on Protein: 149-291
Range on HMM: 3-146/148.0
LPHYPSEILPHFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPE-TVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSAT
|  .|||| . ||.||. ..| .     .. .   .| . .   |. . ... .|| ..| |. .|   ||.. .|..  ... ..|||  . |.|||. 
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

LVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
|. ..|| .|..  | ||..... |. |.| . |. || |.|. 
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0051429 (Phosphotyrosine protein) phosphatases II 149-290 3e-09 32.4 In-house 12-222 (272) alignment 
Range on Protein: 149-290
Range on HMM: 12-222/272.0
LPHYPSEILPHFLYLGDER---HAYNPLLSYDIKIKGHINVSSDLYSAWP------ETVNEVHVDVQDVPQANLLERF----------------------
.. | ....|..||...      | .    .. .||  ... |. . ..       . .. .|... |      |  .                      
vggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------EEVCSFIESYRKkSETVLVFGNKGMSRSATLVAAYLIYyKNMN--------------HKVALDYIRNCRPNVKP
                          |......|  .. .. |||  . |..|..|.||..|..  ...                 |....| .||.. .
lllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavq

LKSFVDQLKEWEK
   .. .| |...
teeqylflyeall
0048076 (Phosphotyrosine protein) phosphatases II 150-291 4.4e-29 96.4 In-house 1-141 (145) alignment 
Range on Protein: 150-291
Range on HMM: 1-141/145.0
PHYPSEILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLV
|..||||||. ||||.  .|..  |  | .|.  .|..|.|.   .. .. ..... | .  .||| ..|.. |||...|. . |||. . |..|..|||
pywpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

AAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
||||.......   ||...|..||.. |  ... .|.|.|..
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 150-290 1e-27 92.0 In-house 1-142 (144) alignment 
Range on Protein: 150-290
Range on HMM: 1-142/144.0
PHYPSEILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETV--NEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSAT
|..||||||. ||||.  .|..  |  . .|.  ||.... . ...|    . .|... | .  .||| ..|.. |||....... |||  . |..|..|
psnpseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgt

LVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
||||||....... . ||...|..||.. |  ... .|.|.||
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP6_pd Subfamily DSP6 150-291 1.1e-26 87.2 In-house 11-153 (158) alignment 
Range on Protein: 150-291
Range on HMM: 11-153/158.0
PHYPSEILPhFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETV--NEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSAT
 ..| |||| .|||| ...| |  .  . |||  .|| |.| ... |.   . ... ..|. ..|| . | |  .||.  |.|...|||    |.||| |
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.. |||. ....  . | |.... ..|. |  .|..||...|..
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_LRR-DSP_pd Subfamily LRR-DSP 152-290 3.9e-26 85.7 In-house 119-256 (263) alignment 
Range on Protein: 152-290
Range on HMM: 119-256/263.0
YPSEILPHfLYLGDERHAYNPLLSYDIKIKgHI-NVSSDLYSAWPETVNEVHV-DVQDVPQANLLERFEEVCSFIESYRKKSeTVLVFGNKGMSRSATLV
 |.||... |.||    | |  .  |  .  ||    .|.   .|..   . . |..||..|..   |||. .|||. |||   |||    |.|||.|||
vPdeiidk.lflGgldsannksilkdlgvt.hillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlv

AAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
 .||. ..... | ||| . . ||...| . |.|||| .||
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
PTPc_motif_SM00404 153-291 8.5e-31 101.7 In-house 2-140 (140) alignment 
Range on Protein: 153-291
Range on HMM: 2-140/140.0
PSEILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYS-AWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAA
||.|||| |||| ...| || |   ..|.  |||..        . .. ......|  ...|.. ...| .|||. .|| ..|||.   |.||||||..|
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
||..|.... . |...... ||...|  .|| || |.||.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_Slingshot_pd Subfamily Slingshot 153-291 3.5e-23 75.8 In-house 19-156 (169) alignment 
Range on Protein: 153-291
Range on HMM: 19-156/169.0
PSEILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAY
.|.|  | .||| |  | |     . ...  .||. .. . .||... ... | | ....||. ..|  .|||  .||   |||   .|.||||. | ||
askifdh.vylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
 .   ... . ||.|... |  .|| |.|. ||.|.| .
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
subfamily_DSP8_pd Subfamily DSP8 153-291 1.3e-21 70.8 In-house 15-153 (159) alignment 
Range on Protein: 153-291
Range on HMM: 15-153/159.0
PSEILPhFLYLGDERHAYNPLLSYDIKIKGHINVSSDL-YSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAA
| .||. .|||| .... .  |  .. |   .|.|     .   . .. ..| |.|  . .||. |.. ..||.  .... .|||.   |.|||||.. |
ptrilk.nlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
|.. . .|.   |  .... || ..|   |..|| |.|| 
yimktlemsldeayrfvkekrptispnlnflgqLleyeke
subfamily_MSG5_pd Subfamily MSG5 153-293 7.8e-14 45.1 In-house 26-161 (165) alignment 
Range on Protein: 153-293
Range on HMM: 26-161/165.0
PSEILPHFLYLGDERHaYNPLLSYDIKIKGHINVsSDLYSAWPEtVNEVHVDVQDvpQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAY
|  .||. |||  | .  . |||.|. |    .. .||    |  |.  |.. .   ....   . .. . | . . | . .||  . |.||||.|. ||
pllvlpeklylysepk.lkellsfdlvinvakei.ndlellvpa.vkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivay

LIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKMQS
.. | |.  . | | ...   ...|   .. || ||| . |
imkyynlslrdaydklksvaddispsiglifqlmewevals
subfamily_DSP15_pd Subfamily DSP15 155-293 3.1e-22 73.3 In-house 4-140 (151) alignment 
Range on Protein: 155-293
Range on HMM: 4-140/151.0
EILPHfLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPEtVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLI
..||  ||||. | . .  |  . .|   ..|. .     .. ..   . ..| |.|.| . |.|  .|| . | | |.|||    |.|||.|||.|||.
kvlpg.lylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

YYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKMQS
   ..|.. ||. |...|   .|   |  ||||.||...
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl
0051082 (Phosphotyrosine protein) phosphatases II 155-287 2.1e-13 45.6 In-house 10-148 (151) alignment 
Range on Protein: 155-287
Range on HMM: 10-148/151.0
EILPHfLYLGDERHAYNPLLSYDIKIKGHINVSS-----DLYSAWPE-TVNEVHVDVQDVPQANLLERFEEVCSFIESYRKK-SETVLVFGNKGMSRSAT
 . .. ||...  .| .  | .. .||  .|. |      ... .||  .. .|. . | |  .| . |..| .|.| ...| .  |||  . |..|..|
yvtgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

LVAAYLIYyKNMNHKVALDYIRNCRP-NVKPLKSFVDQLKE
|||.||..  ...   ||...| .||  | |   |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_DSP14_pd Subfamily DSP14 156-291 1.7e-25 83.8 In-house 10-143 (157) alignment 
Range on Protein: 156-291
Range on HMM: 10-143/157.0
ILPHfLYLGdERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIY
| |. |.|.  . | .. |    ||   |||. .| .   . ...|.| |.| |.|.| . |.||.  ||. .||   .||.   |.||||.|. |||. 
itps.Lfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmk

YKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
|.... . |  .....|| ..|   |  || ..|| 
yeklsLreayklvksaRpiirPNvGFwkqlidyEkk
PTEN_1 156-291 4.6e-23 77.1 In-house 43-190 (196) alignment 
Range on Protein: 156-291
Range on HMM: 43-190/196.0
ILPHFLYLGDERHAYN-PLLSYDIKIKGHINVSSDL------YSA---WPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKS--ETVLVFGNKGMS
 ....||.| .... .     .  .| ...|.|..       |.      . |.  |....| .  .| | |....||||......  ..|||.   |..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
||.|.|||||.|..... . ||...| .||.. |  ..  .|.| ...
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_DSP19_pd Subfamily DSP19 159-291 2.1e-28 93.6 In-house 17-149 (152) alignment 
Range on Protein: 159-291
Range on HMM: 17-149/152.0
HFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKN
  ||||    |..       ||   .||. ..  ..|. .. ..... |.|...||. ..|.  |||. |.|  .|||  | |.||||..| |||.  ..
prlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkee

MNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.. . ||...|. ||..|| . |. ||||.|. 
lsleealelvrearpcikPneGFikqLkeyeae
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 159-291 4.8e-22 71.9 In-house 8-151 (154) alignment 
Range on Protein: 159-291
Range on HMM: 8-151/154.0
HFLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAWPET---------VNEVHVDVQDVPQANLLERFEEVCSFIESYR--KKSETVLVFGNKGMSRSAT
 |||..    |.| |.    .||  .||.     ....          .. ..... | .. ...|... .  ||..     . . |||  .||.||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
|. .||.  ....   ||  ....|. .|| . |..||. .|| 
llisylmdklkislslalellkdsryiikPnqGflkqleifeke
0043147 (Phosphotyrosine protein) phosphatases II 160-291 1e-18 63.1 In-house 25-159 (172) alignment 
Range on Protein: 160-291
Range on HMM: 25-159/172.0
FLYLGDERHAYNPLLSYDIKIKGHINVSSD---LYSAWPETVNEVHVDVQDVPQAnLLERFEEVCSFIES--YRKKSETVLVFGNKGMSRSATLVAAYLI
....... .| .  . .. .|.  .|. .     .  ... .   .. . | .   ||| ..|...||..   ......|||    |..|..|||||||.
tqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

YyKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
. ....   |....|..||.. . .|.  .|...||.
l.lglsleeavalvrekRpgavqnpsqyrflyyfekl
0049260 (Phosphotyrosine protein) phosphatases II 160-291 5.6e-17 57.3 In-house 14-148 (152) alignment 
Range on Protein: 160-291
Range on HMM: 14-148/152.0
FLYLGDERHAYNPLLSYDIKIKGHINVSSDLYSAW---PETVNEVHVDVQDVPQANLLERFEEVCSFIES-YRKKSETVLVFGNKGMSRSATLVAAYLIY
....|.. .| .  . .. .|.  ... ..|. ..   ..  .  |. . | .  .| . ..... |||  ...|...|||    |..|..|||||||..
tqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

yKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
 .... . |....|..||.. | ...  .|.|.||.
.lgvsleeavalvrekRpgavpnpgqlrflyefekl
subfamily_DSP12_pd Subfamily DSP12 161-293 4.2e-29 95.9 In-house 9-144 (155) alignment 
Range on Protein: 161-293
Range on HMM: 9-144/155.0
LYLGDERHAYNPLLSYDIKIKGHINVSSD---LYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYK
||||. ... .. |  ..||.  . | .     ... . .|.. .... | |....|. ..|...|||. ... ..|||  . |.|||.|.|.|||....
lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkke

NMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKMQS
... . ||. ... .|...| ..|..||| .|||. 
klslekAlklvkekkpeiepNegFleQLklfekmgc
DSPc Dual specificity phosphatase, catalytic domain 161-290 6.9e-27 88.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 161-290
Range on HMM: 1-132/133.0
LYLGDERHAYnPLLSYDIKIKGHINVSSDLYS---AWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYK
|||| . .|  . |  ...|.  |||..         ..  ..... |.|  .... . .||. .|||. ..| ..|||  . |.||||||..|||...|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
|.. . |...... |... |  .|. || |.|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 161-290 6.9e-27 88.9 In-house 1-132 (133) alignment 
Range on Protein: 161-290
Range on HMM: 1-132/133.0
LYLGDERHAYnPLLSYDIKIKGHINVSSDLYS---AWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYK
|||| . .|  . |  ...|.  |||..         ..  ..... |.|  .... . .||. .|||. ..| ..|||  . |.||||||..|||...|
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
|.. . |...... |... |  .|. || |.|.
nlslneAyefvkerrskispnagflrqLleyer
0037934 (Phosphotyrosine protein) phosphatases II 161-290 7.9e-16 53.8 In-house 46-239 (243) alignment 
Range on Protein: 161-290
Range on HMM: 46-239/243.0
LYLGDE--------RHAYNPLLSYDIKIKGHINVSSDL--------------------------------------------YSAWPET-VNEVHVDVQD
|....         ..| .  . .. .|.  ... ..                                             .. .. . ..  .. . |
liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpd

--VPQ--ANLLERFEEVCSFIES-----YRKKSETVLVFGNKGMSRSATLVAAYLIYYK-NMNHKVALDYIRNCRPN-VKPLKSFVDQLKEWEK
  ||.  ..||. ..||..|||.     .......|||    | .|..||.||||.... ...   |....|..||. . .  |.  .| |...
hgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0038934 (Phosphotyrosine protein) phosphatases II 181-290 4.7e-14 47.9 In-house 58-174 (194) alignment 
Range on Protein: 181-290
Range on HMM: 58-174/194.0
KGHINVS--SDLY------SAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESyRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCR
  .|...  . .|      .|  | ..   .|   ||. ..| || ... .. . ......|.|    |..|..|||||||||. .|. . |....| .|
glvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

PNVKPLKSFVDQLKEWEK
|.. |  .....| .. |
pgaipnqdyleallkryk
0040439 (Phosphotyrosine protein) phosphatases II 184-290 4.5e-17 57.9 In-house 83-243 (249) alignment 
Range on Protein: 184-290
Range on HMM: 83-243/249.0
INVSSDLYS-------------------------------------------AWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRK------KSETV
....|. .                                              .|..   |. . | |  .. . ||....|||  ||      |.. |
vmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpv

LVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
||  . |..|..|..||||.     ...... . |....|..||.. .  ..  .| |...
lVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0036282 (Phosphotyrosine protein) phosphatases II 184-292 2.7e-16 55.2 In-house 41-169 (174) alignment 
Range on Protein: 184-292
Range on HMM: 41-169/174.0
INVSSDL---------------YSAWPETVNEVHVDVQDVPQANLLErFEEVCSFIESYRKK--SETVLVFGNKGMSRSATLVAAYLIYYKNM-NHKVAL
... .                 ..  .. .. ... . |    .| . ..|...|.|.....  . .|||  . | .|..|||||||...  . .   ||
vmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdal

DYIRNCR---PNVKPLKSFVDQLKEWEKMQ
|..| .|   |.. .  |.  .| ..||. 
dlvrelRlqrpgmvqtpsQyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 185-291 1.3e-18 62.8 In-house 53-171 (176) alignment 
Range on Protein: 185-291
Range on HMM: 53-171/176.0
NVSSDL-------YSAWPE----TVNEVHVDVQDVPQANLlERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYY-KNMNHKVALDYIRNCR
|. ..        .  |||     .   |... |    .| | ..|.. ||....|. ..|||    |..|..|||||||... |...   ||...|..|
nlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqR

P-NVKPLKSFVDQLKEWEKM
| .. .  ... .|.|.|..
plgavqtpeQyrflyefell
0042113 (Phosphotyrosine protein) phosphatases II 185-290 5.9e-16 54.1 In-house 128-240 (245) alignment 
Range on Protein: 185-290
Range on HMM: 128-240/245.0
NVSSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRK--KSETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNVKP
.|. . ..   | ..  .... | . ..||| ......|......  ....|||  . | .|..|..||||.     ......   |....|..||.. .
evtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavq

LKSFVDQLKEWEK
  |.  .| |...
tpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 187-290 1.2e-17 59.6 In-house 148-269 (278) alignment 
Range on Protein: 187-290
Range on HMM: 148-269/278.0
SSDLYSAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRK--------------KSETVLVFGNKGMSRSATLVAAYLIYYK---NMNHKVALDYIR
 .||.|.  . .. ....  .||  ..|  | |.. ||....|              ....|||  . | .|..|||||||...    ...   |....|
redlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelr

NCRPN-VKPLKSFVDQLKEWEK
..||. . . ...  .| |.. 
sqRpglavqnleqyrflyefll
subfamily_PTPMT1_pd Subfamily PTPMT1 191-291 1e-16 55.9 In-house 69-167 (171) alignment 
Range on Protein: 191-291
Range on HMM: 69-167/171.0
YSAWpeTVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
.. .   |. ... ..|. .|  ||. |.   |||....| ..| |  . | .|||||||.||.. .... ..||......|. ..  |  ...|.|.|.
wkkl..gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

M
 
k
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 192-291 3.3e-10 33.2 In-house 41-140 (145) alignment 
Range on Protein: 192-291
Range on HMM: 41-140/145.0
SAWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
..  | .. . .  .|.   .| . |.||  ||.  ...   |.|    |.||| |.  |.|. | ||    |   .|  |    |   |. .| . || 
elksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekq
0051299 (Phosphotyrosine protein) phosphatases II 193-275 3.8e-09 31.9 In-house 177-268 (288) alignment 
Range on Protein: 193-275
Range on HMM: 177-268/288.0
AWPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKK----SETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNV
   |. .  |  . . |  .  . .|.. .|..  ||.    . .|.|  . | .|..|..|..|.     . . ..   |. ..|..||..
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm
subfamily_STYX_pd Subfamily STYX 194-291 3e-16 52.9 In-house 59-156 (166) alignment 
Range on Protein: 194-291
Range on HMM: 59-156/166.0
WPETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEKM
.|..   . .|| | .  |..  . .| .||..  .|   ||| || |.||||.|| ||..    .... |  |... |  ..| . ||.||||.| .
fpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0045450 (Phosphotyrosine protein) phosphatases II 194-290 3.4e-16 55.3 In-house 153-301 (307) alignment 
Range on Protein: 194-290
Range on HMM: 153-301/307.0
WPET---------------------VNEVHVDVQDV-----------------PQANLLERFEEVCSFIESYRK------KSETVLVFGNKGMSRSATLV
||..                     .   .. |.|                  |  .. . |||...|||  ||      |.. |||  . |..|..|..
wPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfi

AAYLIYYKN--------MNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
||||...          ..   |....|..||.. .  ..  .| |...
aaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0047943 (Phosphotyrosine protein) phosphatases II 195-281 7.6e-11 37.4 In-house 163-260 (273) alignment 
Range on Protein: 195-281
Range on HMM: 163-260/273.0
PETVNEVHVDVQDVPQANLLERFEEVCSFIESYRK------KSETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNVKPLKSF
.|.    |. . . |  .  . .|.. .|||  ||      ....|.|  . | .|..|..|..|.     ...... . |. ..|..||.. .  ..
gesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0036941 (Phosphotyrosine protein) phosphatases II 196-289 8.4e-14 47.0 In-house 166-273 (297) alignment 
Range on Protein: 196-289
Range on HMM: 166-273/297.0
ETVNEVHVDVQDVPQANLLERFEEVCSFIESYRK------KSETVLVFGNKGMSRSATLVAAYLI--------YYKNMNHKVALDYIRNCRPNVKPLKSF
|.    |  . . |  .. | .... .|||  ||      ... |||  . | .||.|..||.|.        ...... . |. ..|..||.. .  ..
esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleq

VDQLKEWE
  .| |..
yrflyeal
0050432 (Phosphotyrosine protein) phosphatases II 196-275 5.9e-09 31.1 In-house 195-281 (308) alignment 
Range on Protein: 196-275
Range on HMM: 195-281/308.0
ETVNEVHVDVQDVPQANLLERFEEVCSFIESYRKK--SETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNV
|.    |    . |  .  . .|.. .|.|  ||.  .....|  . | .|..|..|..|.     . ....   |. ..| .||..
esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
0040438 (Phosphotyrosine protein) phosphatases II 197-289 2.4e-14 48.8 In-house 155-272 (317) alignment 
Range on Protein: 197-289
Range on HMM: 155-272/317.0
TVNEVHVDVQDV----------------PQANLLERFEEVCSFIESYRKK----SETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNC
 ..  .. |.|                 |  .. . .... .|.|  |..    .. |||  . | .|..|..||||.     ...... . |....|..
gitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreq

RPNVKPLKSFVDQLKEWE
||.. .  ..  .| ...
Rpgavqtpeqyrflydal
0049772 (Phosphotyrosine protein) phosphatases II 198-291 3.4e-23 78.3 In-house 181-272 (314) alignment 
Range on Protein: 198-291
Range on HMM: 181-272/314.0
VNEVHVDVQDvPQANLLERFEEVCSFIESYrKKSETVLVFGNKGMSRSAT-LVAAYLIYYKNMNHKVALDYIRNCRPnVKPLKSFVDQLKEWEKM
.. ....| | ..|.||| |.|.. |||.. .| . |||  . |..|..| .|||||... ... . ||...|..|| ..| ..|. ||...|..
ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_DSP3_pd Subfamily DSP3 198-290 1.4e-18 61.0 In-house 63-155 (162) alignment 
Range on Protein: 198-290
Range on HMM: 63-155/162.0
VNEVHVDVQDVPQANLLERFEEVCSFIESY-RKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRpNVKPLKSFVDQLKEWEK
.. . ..|.|||...| . ||.. .||..   .|.  |||  ..|.||||||| |||. ...|. . |.  .|. | .. | . |. ||.| ..
ikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaelde
0043336 (Phosphotyrosine protein) phosphatases II 198-289 3.4e-12 41.9 In-house 173-273 (278) alignment 
Range on Protein: 198-289
Range on HMM: 173-273/278.0
VNEVHVDVQDVPQANLLERFEEVCSFIESYRK----KSETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEW
   .|.   ..|  .. | .. ...|..  |.    ... |||  . | .|..|..|.||.     ......   |....|..||.  .  |.  .| |.
rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

E
.
l
0039614 (Phosphotyrosine protein) phosphatases II 201-290 1.5e-14 49.6 In-house 189-286 (297) alignment 
Range on Protein: 201-290
Range on HMM: 189-286/297.0
VHVDVQDVPQANLLERFEEVCSFIESYRK---KSETVLVFGNKGMSRSATLVAAYLI-----YYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
 ...  |    ..|| . |.. .......   |.. |||  . | .|..|..||||.     ...... . |....|..||.. .  |.  .| ....
qytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0046845 (Phosphotyrosine protein) phosphatases II 201-275 1.5e-08 29.8 In-house 168-256 (284) alignment 
Range on Protein: 201-275
Range on HMM: 168-256/284.0
VHVDVQDVPQANLLERFEEVCSFIESYRKK------SETVLVFGNKGMSRSATLVAAYLIYYK--------NMNHKVALDYIRNCRPNV
 |  . . |  .  . .| . .|..  |.       .....|    |..|..|..|..|...         ...   |. ..|..||. 
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
subfamily_DSP23_pd Subfamily DSP23 202-274 3.6e-07 25.0 In-house 56-127 (148) alignment 
Range on Protein: 202-274
Range on HMM: 56-127/148.0
HVDVQD--VPQanlLERFEEVCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPN
.. ..|   |    ||. .|    .|   .|.|.| |   .|. |. |..| ||.  ...    |.  .|. || 
rlriddyhppa...leqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
subfamily_DSP11_pd Subfamily DSP11 202-289 5.4e-07 23.7 In-house 86-174 (178) alignment 
Range on Protein: 202-289
Range on HMM: 86-174/178.0
HVDVQDVPQANLLERFEE-VCSFIESYRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWE
..  ..||. .|...|.| | .|.|.  .. . . |   .|. |.  |.  |||  .... . |..   ..|      . ....||. |
ncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkle
PTPc_DSPc_SM00012 202-273 1.5e-06 23.7 In-house 4-87 (105) alignment 
Range on Protein: 202-273
Range on HMM: 4-87/105.0
HVDVQDVPQANLLERFEEVCSFIESYRKKSE------TVLVFGNKGMSRSATLVAAYLIYYKNMNHKvaldyirnC--------------RP
|. . . |. .. |. ......... .|. .       |.|    | .|..|.||..... ......                       ||
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket........kevdifqivkelrkqRp
subfamily_RNGTT_pd Subfamily RNGTT 207-284 4.1e-06 20.6 In-house 90-166 (189) alignment 
Range on Protein: 207-284
Range on HMM: 90-166/189.0
DVPQANLLERFEEVCSFIESyRKKSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQ
. |.|.  ..| ....   . .. .|.. |    |  |.  |...||.  .... . |..  ...||     . ....
eaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylke
subfamily_CDC14_pd Subfamily CDC14 208-274 9.4e-07 23.0 In-house 246-306 (328) alignment 
Range on Protein: 208-274
Range on HMM: 246-306/328.0
VPQANLLERFEEVCSFIesyrkkSETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPN
.|. .....| |..  .      . .. |    |. |  ||.|.||..  ..... |. ..| ||| 
tPsdaivkkfleiaeka......eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPG
0048567 (Phosphotyrosine protein) phosphatases II 212-277 7.6e-11 36.6 In-house 62-123 (157) alignment 
Range on Protein: 212-277
Range on HMM: 62-123/157.0
NllerfeeVCSFIESYRKKSETVLVFGNKGM---SRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKP
        . .|........ .. |.   |.   .|.|||...|||.. ...   |....| .||. .|
k.......lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_PTPDC1_pd Subfamily PTPDC1 232-290 6.2e-07 24.0 In-house 115-173 (182) alignment 
Range on Protein: 232-290
Range on HMM: 115-173/182.0
ETVLVFGNKGMSRSATLVAAYLIYYKNMNHKVALDYIRNCRPNVKPLKSFVDQLKEWEK
. | |    |. |   |.|.||.| |... . |.. .|. ||.    .. |. .||...
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefal